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Biomedical subjects

G T Blake

Publications and source records attributed to G T Blake.

7 recordsLinked to original sources
PubMed1988

Strenuous exercise causes systemic endotoxemia.

Eighteen triathletes were studied before and immediately after competing in an ultradistance triathlon. Their mean plasma lipopolysaccharide (LPS) concentrations increased from 0.081 to 0.294 ng/ml (P less than 0.001), and their mean plasma anti-LPS immunoglobulin G (IgG) concentrations decreased from 67.63 to 38.99 micrograms/ml (P less than 0.001). Both pretriathlon plasma LPS and anti-LPS IgG levels were directly related to the intensity of training (P less than 0.02 and P less than 0.01, respectively). It is possible that training-induced stress led to some leakage of LPS into the circulation, which, in turn, resulted in self-immunization against LPS. The effects on athletic performance in relation to exercise-induced changes in plasma LPS and anti-LPS IgG levels require further investigation.

Adult↗
PubMed1985

Indoprofen, a non-steroidal anti-inflammatory analgesic which does not depress respiration in normal man. A study comparing indoprofen with morphine.

The respiratory effects of intravenous indoprofen 400 mg, a highly effective non-steroidal anti-inflammatory analgesic, were compared with those of morphine 10 mg in 10 healthy volunteers. Morphine exhibited its characteristic adverse respiratory depressant properties, Indoprofen, in contrast, did not influence the subjects' breathing pattern.

Adolescent↗
PubMed1984

An evaluation of the pulse-contour method of measuring cardiac output.

The pulse-contour (PC) method continuously derives the cardiac output in litres per minute from the arterial pressure wave form by using a portable analogue computer. The reliability of the PC method in determining cardiac output was studied in 6 patients during anaesthetic induction for cardiac surgery. The results obtained with the PC method using the radial artery to register the arterial pulse wave were compared with cardiac output measurements using the more conventional thermodilution technique. The PC method would seem to offer a simple, clinically useful method for on-line monitoring of short-term variations in cardiac output.

Adult↗
PubMed1976

Normal values for ventilatory function in Rhodesian Africans.

Forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow were measured in 141 African men and 102 African women aged 20 and above. Prediction formulae relating each measurement to height and age were drawn up and are presented. Rhodesian Africans have lower values for these measurements than subjects in some Europen and North American series, but broadly similar values to those of Africans elsewhere.

Adult↗