[Tap water magnesium deficiency modulate arterial blood pressure, Ca and Mg tissue distribution, and compartmentation of membrane-bound calcium in thrombocytes of normotensive WKY rats].
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Biomedical subjects
Publications and source records attributed to G T Eschanova.
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The effects of low (8.0 mg/l) and normal (80 mg/l) Ca2+ water diets on systolic blood pressure (SBP) and hypertensive plasma activity were studied. At the end of the 16-week experimental period SBP in the low-Ca2+ group of animals was higher than in the control group after the water treatment: 161 sigma 9 and 120 +/- 4 mm Hg respectively. Significant hypertensive plasma activity of the Ca(2+)-deficient rats was noted in all cases. WKY plasma of the rats of normal-Ca2+ group had no significant effect on SBP. Water correction according to the physiologically recommended levels of calcium can prevent the development of arterial hypertension and occurrence of hypertensive plasma activity.
The arterial pressure was significantly higher in the calcium-deficient group of rats as compared with the normal rats: 150 +/- 7 and 116 +/- 2 mm Hg, resp. The first group of animals had a hypertensive factor in the blood. The hypertensive activity of the calcium-deficient animals was associated with no known pressor agents and was rather similar to Pang's hypertensive factor. The latter was also found in some patients with essential hypertension.
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