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G T Izuno

Publications and source records attributed to G T Izuno.

6 recordsLinked to original sources
PubMed1978

Observations on the in vivo reaction of antinuclear antibodies with epidermal cells.

In evaluating the normal skin of five patients with mixed connective tissue disease, four patients were noted to have both basement membrane zone and speckled epidermal nuclear immunofluorescence. The positive epidermal nuclear reaction was found to be associated with IgG, and no evidence of complement involvement was seen. In vitro testing demonstrated that normal control skin incubated with high-titred antisera to nuclear ribonucleoprotein reporduced the findings observed in direct staining, but incubation with high-titred antisera to other nuclear antigens such as Sm and single-stranded deoxyribonucleic acid did not cause positive epidermal nuclear staining. The association of antibodies to ribonucleoprotein and speckled epidermal nuclear immunofluorescence is discussed. Also considered is the possibility of other factors affecting nuclear membrane permeability.

Antibodies, Antinuclear↗
PubMed1977

Supernumerary areolae.

One of the more unusual forms of supernumerary breast tissue is characterized by the presence of areolar tissue only. The case presented describes a patient with three supernumerary areolae, including one located outside the embryonic milk line. There is a possibility that this finding represents an atavistic phenomenon.

Abdominal Neoplasms↗
PubMedDate not supplied

Acute zinc depletion syndrome during parenteral hyperalimentation.

Zinc is an essential trace element whose malabsorption in early childhood may result in a skin disorder known as acrodermatitis enteropathica. Cutaneous lesions typical of acrodermatitis enteropathica have been described during total parenteral nutrition on zinc-deficient intravenous solutions in both adults and children. This condition has been named the "acute zinc depletion syndrome." A case is described in which a patient, despite a zinc intake of double the daily requirement, manifested the acute zinc depletion syndrome during therapy with combined liquid diet plus parenteral hyperalimentation. Predisposing factors in this individual included a short bowel syndrome and a large oral load of calcium lactate. Zinc metabolism is reviewed with attention to alterations in disease and during hyperalimentation. The clinical manifestations, predisposing factors, therapy and prevention of the acute zinc depletion syndrome are discussed.

Acrodermatitis↗