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Biomedical subjects

G T Moore

Publications and source records attributed to G T Moore.

At least 37 records · Page 2Linked to original sources
PubMed1986

Pathophysiology of soman intoxication in primates.

Adult baboons were monitored during intravenous infusion of Soman (1,2,2-trimethylpropyl ester, phosphonofluoridate). Three groups of animals were studied. Two groups were anesthetized with sodium pentobarbital (initial dose, 20 mg/kg), instrumented for measurement of systemic blood pressure (BP), pulmonary artery pressure, cardiac output (CO), ECG, ventilatory flow, translaryngeal pressure (PTL), transdiaphragmatic pressure (Pdi), transpulmonary pressure (PTP), diaphragm EMG, and efferent phrenic nerve traffic (Eph). One group received no Soman and served as controls. In the other group, Soman was infused over 10 min at doses of 13.1, 8.21, 4.92, or 3.3 micrograms/kg. The onset of intoxication occurred within 7-8 min (before the end of the 10-min infusion), manifested by muscular fasciculations, stridorous breathing, copious secretions, and atrioventricular arrhythmias. Mean BP decreased to 30 mm Hg by the combination of decreased CO and decreased vascular resistance. There was a dose-related response in the onset and duration of these effects. Apnea occurred in most animals and coincided with cessation of the Eph signal. Stimulation of the diaphragm via the phrenic nerve following apnea yielded Pdi values unchanged from baseline, indicating an intact neuromuscular apparatus. All animals required ventilatory support. Some surviving animals exhibited severe behavior changes. The third group of animals was studied without anesthesia. Instrumentation was performed 3 days before using a tether system for the measurement of BP, CO, and ECG, and an arterial line for blood withdrawal. Soman was infused over 10 min at a dose of 13.1 micrograms/kg. The onset of intoxication occurred within 2-3 min, manifested by hyperactivity, severe muscle fasciculations which simulated grand-mal convulsions, stridorous respiratory sounds, copious secretions, and cardiac arrhythmias. Apnea and severe lactic acid acidosis developed in all animals and all required ventilatory assistance. None recovered spontaneous ventilation at the end of 4 hr.

Animals↗
PubMed1980

Age estimation in baboons (Papio cynocephalus) using dental characteristics.

Criteria for estimating the age of baboons using dental characteristics have been developed and tested. These criteria used eruption, wear, and color of the premolars and molars to characterize the ages of baboons in the range of 4--11 years of age. Ages greater than 11 were grouped into a single category. Using the criteria, three judges estimated independently the ages of 49 baboons, of known and unknown ages and of both sexes, with good agreement and precision. The rank order of the estimated ages was similar to the rank order of true ages for colony born animals.

Age Determination by Teeth↗
PubMed1979

Rearing of conventional and gnotobiotic nonhuman primates (Pan troglodytes, Papio cynocephalus, Saguinus nigricollis).

Rearing techniques for conventional and gnotobiotic nonhuman primates are described. Up to four months of age there was no significant difference in weight gain between conventionally and gnotobiotically reared chimpanzees or baboons. After four months, gnotobiotic chimpanzees exceeded their conventional counterparts in weight gain, whereas conventional baboons showed higher weight gain than gnotobiotic baboons. Gnotobiotic chimpanzees and baboons had significantly lower absolute numbers of neutrophils than their conventional counterparts, but the absolute numbers of lymphocytes were not different. The gnotobiotic rearing of marmosets is also reported.

Animal Feed↗
PubMed1976

Baboon infant produced by embryo transfer.

An embryo was recovered surgically from a naturally ovulating, naturally inseminated Papio cynocephalus female on day 5 of gestation and transferred surgically to a naturally synchronized, nonmated Papio cynocephalus female on 20 March 1975. A male baboon weighing 875 grams was delivered by cesarean section on 5 September 1975, 174 days after estimated ovulation time.

Animals↗
PubMed1976

Direct and indirect blood pressure measurements in baboons.

The accuracy and precision of indirect blood pressure measurements in baboons were studied by comparing the results of indirect measurements with simultaneous direct measurements. The indirect measurements were made by four observers using a Doppler ultrasound instrument. A statistically significant difference between the two methods was found for systolic blood pressure but not for diastolic blood pressure. The indirect systolic averaged 13.8 mmHg higher than direct systolic and was found to be more precise than the indirect diastolic. The difference in blood pressure obtained by the two methods varied over animals and observers with an interaction between animals and observers. The effect of arm was examined by performing direct blood pressure measurements in both arms. No statistically significant arm effect was found.

Animals↗
PubMed1976

Weight of the infant baboon (Papio cynocephalus) from birth to fifteen weeks.

Male and female weight percentiles for 24 nursery reared infant baboons (Papio cynocephalus) were developed from weight measurements made from birth to 15 weeks of age. True birth weights could not be obtained and weights at the time of removal from the mother (18-24 hours after parturition) were used as initial weights. The difference in initial weights for males compared to females was found to be statistically significant with males having greater initial weights.

Animals↗
PubMed1975

Comparison of television and telephone for remote medical consultation.

Television and telephone communications were randomly used to compare their effectiveness in allowing consultation between a hospital-based physician and remote nurse practitioners. Visits using television for consultation averaged 50 minutes as compared with 40 minutes for telephone. This difference was caused by longer work-ups before the consultation, longer delays after it was requested, and longer consultations, themselves, on television. However, television consultations resulted in significantly fewer immediate referrals of patients to hospital physicians: 6 plus or minus 1 as compared to 12 plus or minus 1 per cent (mean plus or minus S.E.M) OF ALL TELEPHONE CONSULTATIONS (P SMALLER THAN 0.005). Although no overall difference in satisfaction was documented between the results of television and telephone consultations, participants preferred the former for medical decision making and cited it for allowing more social interaction than telephone. These findings suggest that television may have its greatest value in remote sites where the sense of isolation is great and the need to reduce long-distance referrals offsets the costs of the system.

Community Health Services↗
PubMed1975

The breeding and utilization of baboons for biomedical research.

The baboon (Papio cynocephalus) has been used extensively for biomedical research at the Southwest Foundation for Research and Education (SFRE) since 1958. This animal model has adapted well to captivity, has reproduced efficiently, and has proved to be very useful in many areas of medical research. Reproductive data from the SFRE baboon colony, the establishment of a breeding colony from imported animals, the present use of baboons as research models, and the predicted availability and use of these animals were discussed.

Animals↗