Biomedical subjects
Publications and source records attributed to G T Peake.
Changes in endogenous prolactin levels in rats with age and after ovariectomy varied according to the reproductive state, emphasizing the different mechanisms underlying infertility in rats in constant oestrus and prolonged dioestrus.
The role of prostaglandins in both FSH- and LH-mediated increases in ovarian cyclic AMP was examined in rats in vivo. Dose-related increases in ovarian cyclic AMP levels were observed 10 min after intravenous injection of FSH or LH. No changes in ovarian prostaglandin E (PGE) content were detected after injection of either gonadotrophin at doses which substantially enhanced cyclic AMP accumulation. Prior treatment of rats with indomethacin produced a greater than 50% decrease in ovarian PGE levels, but did not prevent the FSH- or LH-induced rise in ovarian cyclic AMP concentration. These in vivo experiments do not support the concept that PGE plays a role as an obligatory mediator for the gonadotrophin-induced rise in ovarian cyclic AMP levels.
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To study the effect of changing serum osmolality on serum prolactin concentration 11 volunteers were given oral and intravenous hypotonic and hypertonic fluids. Mean serum prolactin fell to 10.5 percent of baseline after oral water loading and to 15 percent of baseline after intravenous hypotonic saline infusion. Conversely, mean prolactin rose to 417 percent of baseline after intravenous hypertonic saline administration. The correlation coefficient of simultaneously determined serum prolactin and osmolality was highly significant (P .001). Isoosmolar changes in extracellular fluid volume did not consistently affect the concentration of prolactin in the serum. Thus, prolactin may be involved in the physiologic regulation of osmolar balance and the kidney may be an important farget organ for prolaction.
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