Biomedical subjects

G T Terézhalmy

Publications and source records attributed to G T Terézhalmy.

3 recordsLinked to original sources

PubMed1994

General principles of pharmacology.

Historically, the clinician was responsible for information about the sources, physical and chemical properties, compounding, and dispensing of drugs. These activities are now delegated to pharmacologists and pharmacists. Today the practitioner's responsibility requires the rational clinical use of therapeutic agents for the prevention, diagnosis, and treatment of disease. Understanding how chemicals act on body homeostasis at the molecular level is the foundation for developing new drugs. Understanding drug actions at the molecular level is also the basis for rational pharmacotherapy. In addition, it has been emphasized repeatedly that drugs seldom exert their beneficial effects without also causing adverse side effects. The inevitability of this therapeutic dilemma lends credence to the statement that there are no safe biologically active agents. In dealing with this certainty, once again, the clinician trained in molecular mechanisms of drug action, principles of disposition, pharmacotherapeutics, and toxicology has the advantage.

Absorption↗

PubMed1994

Acetylsalicylic acid and acetaminophen.

Aspirin is the most extensively prescribed analgesic, antipyretic, and anti-inflammatory agent. It is effective against the mild-to-moderate pain of inflammation. The best single dose of aspirin is that which is adequate to relieve pain; the proper dosage interval is that which sustains relief without causing toxicity. It would be unfortunate to withhold aspirin from a patient who desperately requires the relief provided by this most useful analgesic because there have been some adverse effects when it is used improperly. Acetaminophen is a suitable substitute for aspirin for its analgesic or antipyretic uses in patients in whom aspirin is contraindicated (e.g., prepartum patients, children with febrile conditions, patients with asthma, peptic ulcer, gouty arthritis, hyperuricemia, hemophilia or other bleeding disorders, and those taking anticoagulants). However, the general substitution of acetaminophen for aspirin as an analgesic is not recommended.

Acetaminophen↗

PubMed1994

Adverse drug effects.

It has been emphasized repeatedly that drugs seldom exert their beneficial effects without also causing adverse side effects. The frequency of clinically important adverse effects is difficult to estimate, but the potential for drug-drug and drug-disease interactions and drug-induced illness is high and lends credence to the statement that there are no safe biologically active agents.

Dental Care↗