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Biomedical subjects

G T du Toit

Publications and source records attributed to G T du Toit.

10 recordsLinked to original sources
PubMed1985

Osteochondral hemiarthroplasty. An experimental investigation in baboons.

Hemiarthroplasty using osteochondral autografts and allografts were performed on 40 hip, 23 knee and 5 shoulder joints in baboons. Follow-up at one, two and three years revealed good results as assessed by clinical and radiological examination. Histological and radionuclide studies revealed cartilage viability in 70 to 80% of cases.

Animals↗
PubMed1985

Pathologic features of the femoral head in Mseleni disease.

Severe but atypical osteoarthritic deformities were found in each of 12 femoral heads removed during total hip arthroplasty for Mseleni disease. Although degenerative and regenerative changes were present throughout the cartilage, there was a paucity of eburnation. Histomorphometric analysis of bone at the line of excision indicated that mild osteomalacia was present in four of the 12 specimens. The percentage of the endosteum occupied by osteoid was 9.7 +/- 7.96 (SD) in the patients with Mseleni disease, compared with 5.6 +/- 4.33 in seven African black and 4.1 +/- 2.13 in 13 American white control subjects. The mean thickness of the osteoid seams was not increased. The findings suggest that osteomalacia is not a major pathogenetic factor in Mseleni disease.

Adult↗
PubMed1982

Arthroplasty by osteocartilaginous graft in primates.

Joint surface grafting has evolved from use of cadaveric materials preserved chemically and physically, to viable allogeneic and autogenic grafts in nearly a century of surgical history. Technical problems arising at the interface between foreign substances and living tissues has limited engineering arthroplasty such that a biological grafting process is eagerly sought. If successful with long periods of joint functioning, the scope of application to human victims of trauma, disease, and tumors of joints is wide. Whereas rabbits and dogs have been extensively used as models, primates have not. Whereas osteochondral allografts in Papio ursinus (the South African baboon) have been quite successful in hip, knee and shoulder joints, but the follow-up has been no more than a few years. Human autografts have been successful with periods of 10 and 15 years, but the present series is inadequate for statistical assessment. Further investigations of allografts and autografts in human joints are warranted.

Adolescent↗