PubMed Health⌕ Search

Biomedical subjects

G Tóth

Publications and source records attributed to G Tóth.

At least 181 records · Page 10Linked to original sources
PubMed1981

Localization of glyceraldehyde-3-phosphate dehydrogenase in intact human erythrocytes. Evaluation of membrane adherence is autoradiographs at low grain density.

Human erythrocytes were treated with highly tritiated [3H]iodoacetate under conditions when half of the label became attached to glyceraldehyde-3-phosphate dehydrogenase. After fixation, the cells were subjected to electron microscopic autoradiography. For the evaluation of distribution of grains, which were relatively few, a computerized method was developed. Statistical analysis of data showed the significant adherence of grains to the cell membrane. The results support the view that glyceraldehyde-3-phosphate dehydrogenase is localized near the membrane in the intact erythrocyte.

Erythrocyte Membrane↗
PubMed1980

Maturation of the circadian rhythm of the adrenocortical functions in human neonates and infants.

The cortisol levels in the peripheral blood were measured radioimmunologically at 08.00, 12.00,. 16.00, 20.00, 24.00 and 04.00 h in human neonates and infants with ages of 1, 2 and 3 days, 1, 2 and 4 weeks, 2, 3 and 6 months and 1 and 3 years. During the first 2 days of extrauterine life the neonates had high plasma cortisol levels without a circadian rhythm. During the first 2 months there were decreased cortisol levels in the infants, but the diurnal rhythms were still absent, and free-running fluctuations were observed. The typical circadian rhythms of the plasma cortisol levels were present in infants aged 3 months; these rhythms were identical with the diurnal changes of 1- and 3-year-old infants. In the groups of patients studied the data suggest that the circadian rhythm of the adrenocortical function may develop to the adult-type pattern already during early infancy.

Adrenal Cortex↗
PubMed1979

Hyperaldosteronism in the sodium-depleted rat: mode of aldosterone-stimulating action of frusemide.

The mechanism of diuretic-induced hyperaldosteronism was examined in dexamethasone-pretreated rats. The diuretic drug frusemide brought about a rapid increase in plasma renin activity and aldosterone concentration in serum. Half an hour after the administration of frusemide the mean concentration of aldosterone was 25 times higher than in vehicle-treated control animals. Administration of SQ 20,881, an inhibitor of angiotensin converting enzyme, prevented the adrenal response to frusemide. The response of aldosterone was completely blocked by indomethacin. This drug reduced renin release and probably also inhibited the effect on the adrenal glands of angiotensin, released in response to frusemide. Our results indicate that the effects of diuretics on the adrenal glomerulosa cells are mediated by the renin-angiotensin system also in the rat. Hyperaldosteronism is dependent on the maintenance of prostaglandin synthesis. ACTH has no essential role in this response.

Adrenal Glands↗
PubMed1977

Regulation of phosphorylase-phosphatase from skeletal muscle by phosphorylation of a regulator protein.

The inhibitory effect of a heat-stable regulator protein from skeletal muscle on the activity of phosphorylase-phosphatase (EC 3.1.3.17) was studied. The regulator protein was shown to be both phosphorylated and dephosphorylated in vivo as well as in vitro. The incorporation of phosphate into the regulator protein increased, while dephosphorylation decreased the ability of the protein to inhibit phosphatase activity. Our results suggest that the reversible phosphorylation of the regulator protein plays an essential role in the regulation of phosphorylase-phosphatase activity.

Animals↗
PubMed1976

Effect of orotic acid on liver glycogen of different animal species.

The effect of orotic acid on the liver glycogen content in the mice, frogs and catfish was studied. It was observed that the orotic acid significantly increases the glycogen content in the liver of mice and catfish as it does in rats. On the other hand it causes a fall of the glycogen level in frogs in experiments made both in autumn and spring. This effect was modified by amino acids administered together with orotic acid.

Animals↗