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Biomedical subjects

G Töndury

Publications and source records attributed to G Töndury.

At least 19 recordsLinked to original sources
PubMed1982

Cytodifferentiation of human fetal lung tissue following transplantation into "nude" mice.

Lung fragments from 10 human fetuses aged 10 to 14 weeks of gestation were implanted into athymic "nude" mice. Cytodifferentiation of the transplants was studied by both scanning and transmission electron microscopy. Two weeks after implantation mitotic figures of epithelial and stroma cells were observed. In five week old transplants ciliated as well as endocrine cells were found dispersed among undifferentiated bronchial epithelium. During further experimental period epithelial differentiation in the transplants proceeded. Thus, eight week old implants assumed the morphologic appearance of fetal lungs in the canalicular stage displaying prospective type I and II pneumocytes. In addition stroma cells also differentiated forming mature fibroblasts and myofibroblasts. Our study indicates that human fetal lung tissue transplanted into "nude" mice not only grow but even differentiate. Xenogeneic transplantation of human fetal cells and tissues, therefore, offers additional opportunities to investigate the prenatal development of human tissues.

Animals↗
PubMed1978

Origin of the calvaria and its sutures.

Studies indicate that the dura is the guiding tissue in the morphogenesis of the calvaria and its major sutures, which develop from ten to 16 weeks of fetal life. Overlying the central zones between the dural reflections ossification takes place, whereas none occurs over the reflections of dura, these being the suture sites. Strong evidence for the role of the dural reflections in determining the suture sites was obtained from the evaluation of instances of major brain malformations that must have antedated calvarial morphogenesis. These included holoprosencephaly, craniopagus, and dicephaly. The altered dural reflections, which related to the aberrant form of the brain, coincided with the position of the unusual sutures. Furthermore, a lack of a dural reflection was accompanied by a lack of development of a suture at that site.

Brain↗