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Biomedical subjects

G Talukder

Publications and source records attributed to G Talukder.

At least 19 recordsLinked to original sources
PubMed1992

Chromosomal alterations and sister chromatid exchanges induced by zirconium oxychloride in human lymphocytes in vitro with relation to age of donors.

Aqueous solutions of zirconium oxychloride were added to human peripheral blood lymphocyte culture. Cultures were set up from healthy donors of both sexes belonging to age groups of 0-10, 11-20, 21-30, 31-40, 41-50 and 51-60 years. Airdried Giemsa schedule was followed for preparation of chromosomal aberrations and micronuclei count. Flourescence plus Giemsa staining techniques were applied for the study of sister chromatid exchange. The endpoints screened were chromosome and chromatid breaks, dicentrics and rearrangements. The frequencies of chromosomal aberrations and sister chromatid exchanges induced were compared between the samples of different age groups. The frequency of CA could not be related to age of the donor. However, the frequency of SCE increased with increase in age of female donor.

Adolescent↗
PubMed1992

Interaction between two group IV metals--lead and zirconium--in bone marrow cells of Mus musculus in vivo.

The interaction between two group IV metals, the highly toxic lead and the relatively inactive and low toxic zirconium, was studied in the bone marrow chromosomes of Mus musculus in vivo. Low and high doses of zirconium oxychloride were fed orally to the experimental mice (i) 2 h before, (ii) 2 h after or (iii) together with different doses of lead nitrate. Protection against lead-induced clastogenicity was observed only when the lower dose of zirconium was administered prior to lead. All other combinations gave an additive or synergistic effect as was seen by significant increases in the frequencies of chromosomal aberrations.

Animals↗
PubMed1992

Comparison of the clastogenic effects of antimony trioxide on mice in vivo following acute and chronic exposure.

Antimony trioxide (Sb2O3), in aqueous suspension, was administered by gavaging to mice and monitored for chromosomal aberrations in bone marrow and sperm head abnormalities in germ cells. Acute exposure to the doses followed by observations after 6, 12, 18 and 24 h did not show any clastogenic effects. Chronic exposure daily to different doses for periods up to 21 days induced chromosomal aberrations in bone marrow. The frequencies were dose-dependent to a significant extent but no relationship could be seen with the sex of the animal. The findings indicate the harmful effects of cumulative exposure for prolonged periods to Sb2O3, which is being increasingly used in various industries.

Administration, Oral↗
PubMed1992

Modifying effect of iron on lead-induced clastogenicity in mouse bone marrow cells.

Essential trace elements such as iron (Fe) are known to interact with nonessential metals like lead (Pb), influencing its metabolism. Ferric chloride and lead nitrate were administered intraperitoneally to Swiss albino mice Mus musculus singly and successively, with or without a time gap of 1 h, to study the degree of protection, if any, afforded by iron against the clastogenic effects induced by Pb in bone marrow cells. A decrease in the frequency of lead-induced chromosomal aberrations was observed when Fe was given together with or prior to Pb administration.

Animals↗
PubMed1992

Zirconium. An abnormal trace element in biology.

The action of Zirconium (Zr) on biological systems presents an enigma. It is ubiquitous, being present in nature in amounts higher than most trace elements. It is taken up by plants from soil and water and accumulated in certain tissues. The entry into animal systems in vivo is related to the mode of exposure and the concentration in the surrounding environment. Retention is initially in soft tissues and then slowly in the bone. The metal is able to cross the blood brain-barrier and is deposited in the brain and the placental barrier to enter milk. The daily human uptake has been known to be as high as 125 mg. The level of toxicity has been found to be moderately low, both in histological and cytological studies. The toxic effects induced by very high concentrations are nonspecific in nature. Despite the presence and retention in relatively high quantities in biological systems, Zr has not yet been associated with any specific metabolic function. Very little information is available about its interaction with the compounds of the genetical systems, such as nucleic acids. Apparently, the metal is neither an essential nor toxic element in the conventional sense. However, the increasing exposure to this element through its increasing use in new materials and following radioactive fallout, has increased the importance of the study of its effects on living organisms. The tetravalent nature of the ionic state and the high stability of the compounds formed are important factors that need to be considered, as also the accumulation of this element in the brain, reminiscent of the relationship between Al3+ and Alzheimer's disease.

Animals↗
PubMed1992

Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen--caesium chloride.

Aqueous extracts of Phyllanthus emblica L. fruit and an equivalent amount of vitamin C were administered orally by gavage to laboratory-bred Swiss albino mice for 7 days in order to evaluate the protection afforded by the two extracts against clastogenic effects of different doses of caesium chloride (CsCl) on bone marrow cells of Mus musculus in vivo. Both pretreatments significantly reduced the frequency of chromosome aberrations induced by CsCl given at three different doses, indicating that vitamin C, an essential component of P. emblica extract, was the effective agent in protecting against the clastogenicity of the metal salt.

Animals↗
PubMed1992

Cytotoxic effects of antimony trichloride on mice in vivo.

Clastogenic effects of antimony trichloride, used in small industries, were monitored in laboratory bred white Swiss mice in vivo, following oral administration by gavaging, after 6, 12, 18 and 24 h. Chromosomal aberrations were principally breaks and damaged cells observed from bone marrow preparations. The frequencies of chromosomal aberrations were directly related to the dose used and were significantly higher than the control. The chemical did not alter the frequency of dividing cells to any significant level.

Administration, Oral↗
PubMed1992

The blood group and haemoglobin types of the Santals.

A total of 488 blood samples from tribal as well as non-tribal donors of Bihar and West Bengal were analysed for presence of abnormal haemoglobin variants. Out of 488 samples ABO and Rh blood groups were studied in 468 samples. Predominance of group B was noted in both the tribal and non-tribal groups and absence of Rh(d) was noted in non-tribal population with the exception of the tribals where 4.42% Rh(d) gene was found. Incidence of haemoglobin E gene was very low in most cases but relatively higher in non-tribal populations, while the range of raised haemoglobin A2 varied from 5.84% to 8.80%.

ABO Blood-Group System↗
PubMed1992

Cytotoxic effects of Sumicidin, a type II synthetic pyrethroid, on mice in vivo at 6, 12 and 24 h after exposure.

The ability of Sumicidin, a synthetic pyrethroid, to induce cytotoxicity in Swiss albino mice was evaluated before completion of the first cell division following oral exposure. Mice were administered orally different concentrations (32.50, 75 and 150 mg/kg body wt) of Sumicidin in a single dose. Mitotic index and chromosomal aberrations were screened after 6, 12 and 24 h following exposure. The frequency of dividing cells decreased significantly, indicating mitostatic action. The frequency of chromosomal aberrations was directly related to the concentrations used and the duration after exposure, and was significant at all concentrations. The highest frequency of aberrations was observed 24 h after exposure.

Animals↗
PubMed1991

Karyotype studies of patients with gonadal tumors.

Chromosomes from the peripheral blood of 10 patients with gonadal tumors were studied to detect any inherent chromosomal defect. Aneuploidy, breakages and loss of chromosome X were observed. In all cases the karyotype was compatible with the phenotype.

Adenocarcinoma, Mucinous↗
PubMed1978

Hemoglobin variants in India.

The occurrence of different types of hemoglobin variants in India has been well-documented in urban populations and in certain tribal areas. Beta-thalassaemia and hemoglobins D,E,H,S, and rare variants like Hb Lepore, have been found in varying percentages. There is a higher incidence of Hb E in the Eastern region and of Hb D in certain Northern populations. The association of Hb E with beta thalassaemia G6PD deficiency has been established. The relationship with other environmental factors, like malaria, is not yet clear.

Environment↗
PubMed1978

Total protein patterns in human amniotic fluid.

Total protein patterns of amniotic fluid samples of different age groups, following polyacrylamide disc gel electrophoresis, showed a wide range of variation in early pregnancy, but no two cases had identical banding, indenticating their genetic variability. An assessment has been made here of the total protein, albumin and transferrin patterns from normal fluids of different age groups by gel electrophoresis, in order to observe the genetic variations and relationship with foetal age, if any.

Albumins↗