Biomedical subjects

G Tatar

Publications and source records attributed to G Tatar.

23 records · Page 2Linked to original sources

PubMedDate not supplied

Helicobacter felis as a cofactor alone or together with stress in cryptosporidial activation in mice.

Cryptosporidiosis is caused by a protozoan parasite, mainly found in animals, which usually results in transient, mild gastroenteritis in humans but can cause severe and prolonged disease in immunocompromised individuals. Immunocompetent mice, naturally infected with Cryptosporidium muris, were used to investigate the effects of inoculation with Helicobacter felis and of stress on the activity of the C. muris infection, as indicated by histopathological examination of their stomachs. The results indicate that both H. felis inoculation and/or stress activate C. muris and cause gastric inflammation. The extent of the activation of C. muris depends on the duration of the stress.

Animals↗

PubMedDate not supplied

Treatment of chronic hepatitis C infection with interferon alpha-2a in a Turkish population.

Recombinant interferon (IFN) alpha has been shown to normalize the aminotransferase levels in approximately half of patients with chronic hepatitis C virus (HCV) infection. Twenty four patients with chronic HCV infection were treated with IFN alpha-2a subcutaneously, three times a week for 6 months. All patients responded to IFN therapy with a decrease of alanine aminotransferase (ALT) level. Thirteen out of 24 cases (54.2%) had normal ALT levels at the end of the sixth month of therapy. However, four of these complete responders (30.8%) relapsed during the 12 month follow-up. Relapse was high in the partial responder group (45.5%). Overall relapse rate was 37.5% at 6 months. HCV genotype II, which is associated with a low response rate to IFN was prevalent (85-87%) in our patient population. This study shows that interferon therapy can be effective in reducing transaminase levels in patients with chronic hepatitis C in a population with a high prevalence of HCV type II. The relapse rate after discontinuation of treatment, however, remains a problem.

Adult↗

PubMedDate not supplied

Elevated serum soluble Fas levels in the various stages of hepatitis C virus-induced liver disease.

We aimed to determine serum soluble Fas antigen (sFas) levels at various stages of hepatitis C virus (HCV)-induced liver disease, and investigate correlations between serum sFas levels and clinical, biochemical and pathologic features. Sixty-five patients were categorized into five groups: 1, chronic active hepatitis C, elevated alanine aminotransferase (ALT), HCV-polymerase chain reaction (PCR) positive; 2, responders to interferon + ribavirin therapy; 3, cirrhosis; 4, chronic hepatitis C, normal ALT, HVC-PCR positive; and 5, sustained responders. Group 6 comprised 15 control individuals. Serum sFas levels were measured by enzyme-linked immunosorbent assay. Significant differences in serum sFas levels were found between the following groups: 1 and 2; 1 and 3; 1 and 4; 1 and 6; and 3 and 6. Serum sFas levels did not correlate with ALT, histological activity or HCV-PCR positivity within group 1. Serum sFas levels appear to increase in advanced stages of HCV-induced liver disease, as a result of host-related immunological factors.

Alanine Transaminase↗

PubMedDate not supplied

Blue rubber bleb nevus syndrome: report of a case.

A case of blue rubber bleb nevus syndrome (BRBNS) in a 17-year old boy with multiple cutaneous and gastrointestinal hemangiomas is presented. The patient had iron deficiency anemia and pica. In addition, we describe, for the first time, left renal artery, right hepatic artery, and ureteral abnormalities in a patient with BRBNS.

Adolescent↗

PubMedDate not supplied

Superior mesenteric artery syndrome. A case report.

A case of superior mesenteric artery syndrome is reported. A 16-year-old boy with bilious vomiting for six months and weight loss within the previous year is presented. In this symptomatic period, he was fed many dietary formulations. This conservative management failed. Physical examination revealed that he was malnourished. The diagnosis was made by means of an upper gastrointestinal barium study performed through a tube. Gastrojejunostomy was preferred over duodenal mobilization because he had a markedly dilated stomach and enlarged pylorus. The postoperative course was satisfactory.

Adolescent↗