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G Testa

Publications and source records attributed to G Testa.

150 records · Page 9Linked to original sources
PubMedDate not supplied

[Clinicopharmacologic study of blood carbamazepine levels in a group of epileptic patients].

Clinico-pharmacological evaluation on Carbamazepine serum levels was performed in a group of epileptic patients. CBZ (Carbamazepine) blood levels have been detected in a heterogeneous group of epileptic patients taking several other antiepileptic drugs. Patients in which there was a good reduction of epileptic seizures after CBZ was added, had a mean blood level of 4.2 plus or minus 1.4 microgram/ml. When Dyphenilhydantoine (DPH) and/or Phenobarbital (PB) were associated with CBZ they both decreased CBZ blood levels; on the contrary CBZ did not appear to modify DPH and PB blood levels.

Adolescent↗
PubMedDate not supplied

[Effect of gamma-amino-beta-hydroxybutyric acid (GABHB) on experimentally-induced epileptic activity].

Effects of GABOB on experimental induced epileptiform activities. Antiepileptic activity of gamma-amino-beta-hydroxybutyric acid (GABOB) has been tested on different models of either generalized or focal epilepsy induced by penicillin in cat. In acute experiments, topical application to the cortex of GABOB (from 1% to 10%) during feline generalized epilepsy produced a reverse in polarity of the spike and wave complex, while in the so called "epileptogenic corticopathy" it induced a decrease in voltage as well as in frequency of the bilateral spikes and polyspikes. A similar effect was seen after parenteral injection of GABOB in acute preparations in which a penicillin focus was created. In chronic animals, in which feline generalized penicillin epilepsy had been produced, a single i.v. injection of GABOB induced a significant decrease of the epileptic bursts during the first 30' after the antiepileptic drug was injected. Finally in 4 animals chronic administration of GABOB leaded to a mean decrease of the epileptic bursts higher than 50%. These data support the antiepileptic activity of GABOB. However the high doses used in this study to achieve the antiepileptic effect could make difficult its use in human patients.

Animals↗
PubMedDate not supplied

[Thymus gland scan in myasthenia gravis: experience in 52 patients].

A firm relationship has been established between thymus gland pathology and myasthenia gravis. The most frequent changes observed in this gland consist in simple hyperplasia of germinal centers or thymoma. In order to detect these alterations it is necessary to have a suitable reliable technique, beside routine radiological exams: thymus scan has been proposed as an useful tool. Since 1968 we submitted 52 patients to this procedure; we used as a tracer 75Se-Seleniomethionine in most cases, 57Co-bleomycin and 67Ga-citrate in a few cases. The scan was found positive in 22 cases (42%) showing either localized or diffuse uptake in the region of the sternum. Thymus changes were subsequently examined in 26 cases: 22 cases after thymectomy in 4 cases at autopsy. We found a good correlation between positive scan and pathological changes of the gland such as thymoma or germinal center hyperplasia. However in 4 patients with negative scan that previously received radiation therapy or immunosuppressive therapy such pathology was missed: 3 cases of hyperplasia and 1 residual thymoma. We conclude that thymic scan an useful and highly specific diagnostic procedure and should be done before any kind of treatment which affects thymus.

Adolescent↗
PubMedDate not supplied

[Water activity and food stability. I. Effects on viability of Saccharomyces cerevisiae cells (author's transl)].

Biological activity of microorganism is related to water activity (aw). In this paper the effect of glicerol as humectant on Saccharomyces cerevisiae viability was considered. The irreversible loss of viability was observed only for values inferior than 0,75. The K+ presence promoted an increasing of cell viability and growth. We have evaluated the changes of the most important components of cell poll; the increasing of glicerol amount of the system induced a drastic fall of aminoacids, purines and K ions content, but it increased the Na ions content. The exposure of cells to increasing glicerol concentrations, caused an aminoacids and purines excretion related to contact time; after a few hours this material was readsorbed by cells.

Desiccation↗
PubMedDate not supplied

[Use of new elastomeric pumps and PCA in postoperative pain control in thoraco-abdominal surgery].

36 patients submitted to interventions for thoraco-abdominal surgery has been submitted to antalgic post-operatory therapy with elastomeric pump at a continuous intravenous infusion and patient controlled analgesia (PCA). The patients have been randomized in three groups. The patients of the 1 degree group received 30 minutes before of the end of the surgical intervention 30 mg of Ketorolac. At the end of the anesthesia came started an infusion of 150 mg of Ketorolac (5 vials) in 60 ml of isotonic chlorinated solution at the rate of 0.5 ml/h. The pump had besides the capability of disperse a maximum of 4 bolus/ h, everyone of 0.5 ml, on demand of the patient. The 2 degrees group received a solution containing 60 ml of Morphine in 60 ml of isotonic chlorinated solution with the same formality of administration. The 3 degrees group (placebo) received 60 ml of isotonic chlorinated solution in pumps from infusion and Ketorolac intramuscular on demand. To the times T0 (awakening), T1 (3 h), T2 (6h), T3 (12 h), T4 (24 h), T5 (30 h, was collected algometrical consequences according to VAS (Visual Analogous Scale of Sc modification of the PA increase, FC, FR, SatO2.. The obtained results have highlighted like in the 1 degree group, to the 1 degree algometric consequence (T0), there is a good sedative effect on the pain (intensity of the middle low pain 3.70 +/- 1.64); this antalgic effect has also continued in the other consequences effected in the post-operatory. In the 2 degree group to the awakening (T0), the pain was middle-tall (5.50 +/- 2.32) and an expressive reduction appeared at the time T2 (3.60 +/- 1.35 P < 0.005). In the 3 degrees group have not recorded a diminution of the pain if not after 24 hours from the end of the intervention deposit the intramuscular antalgic therapy. In conclusion, the system infusion + PCA represents an indubitable advantage in comparison with the traditional antalgic therapy as for concern the entity of the reduction of the pain as because it permits the use of a smaller quality of drugs.

Abdomen↗