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Biomedical subjects

G Testino

Publications and source records attributed to G Testino.

At least 55 records · Page 3Linked to original sources
PubMed1996

Gastric ulcer and cancer ulcer. Retrospective evaluation of the current endoscopic diagnosis.

Aim of this experience has been to evaluate the current diagnostic potentiality of the endoscopy in the framework of the gastric ulcerous pathology. On the total of the gastric ulcers 17.9% have resulted to be neoplastic with the hystologic examination. The diagnostic accurracy of the endoscopy has resulted to be of the 87% compared to hystology. From our data it is evidenced how the endoscopy examination has a relevant diagnostic accuracy in defining the nature of the gastric ulcer which however has to be confirmed by the histology which seems to be diriment.

Adult↗
PubMed1995

Chronic gastritis: its clinical and physiopathological meaning.

Chronic gastritis (CG) is the chronic inflammation of gastric mucosa associated with varying degrees of damage of superficial and glandular epithelia. The causes of CG are exogenous (mainly Helicobacter pylori) and endogenous. The process is concluded by atrophy of parenchyma. CG is associated with dyspepsia in approximately 50% of cases, but frequently with gastric and duodenal ulcer. The role of chronic atrophic gastritis (AG) is relevant in development of cancer or of other tumors like carcinoids and polyps. The specific secretive cells of the glandular parenchyma and of the superficial epithelium reveal a good correlation with secretory component behavior, but they are only partially influenced by H. pylori. It emerges that CG is an anatomic-functional condition. The cytofunctional profile in AG causes achlorhydria and therefore chronic luminal alkalosis. This condition favors intestinal metaplasia (IM) and important intraluminal troubles. Finally, nutritional deficiencies or H. pylori seem to interfere with the intragastric metabolism and therefore play a relevant role in the rise of IM.

Atrophy↗
PubMed1995

[Influence of Helicobacter pylori on gastric secretion. Study on variously associated gastric body, fundus and antrum chronic gastritis].

Among the various themes related to Helicobacter pylori (HP) which is still a subject of discussion, there is the possible influence of this bacterium on gastric secretory physiology. In the present study, an evaluation has been carried out of stimulated gastrinemia, stimulated acid secretion and total peptic activity in gastric juice in the course of a paradigmatic condition, as autonomous chronic gastritis, in order to reveal possible modifications induced by the HP infection. In cases of HP positive chronic superficial antral gastritis associated either with normal body-fundic mucosa or with superficial gastritis, there is a significant increase of stimulated gastrinemia in comparison to HP negative groups and controls. In the course of body-fundic atrophic and preatrophic chronic gastritis associated either with antral superficial chronic gastritis or with antral atrophic gastritis, there are no statistically significant differences between HP positive and HP negative subjects. As regards acid and pepsin secretion no significant differences emerge in any group between HP positive and HP negative subjects. In the HP positive subjects with antral superficial gastritis and higher gastrin values the study of acid and pepsin secretion has yielded no significant variations. From the results of this study it emerges how gastric secretory parameters vary exclusively according to the histologic state of gastric mucosa. Therefore, the lesion action of HP may mainly be attributed to a direct action, rather than to substantial gastric secretory changes.

Adult↗
PubMed1995

[Total peptic activity in gastric juice and peptic cell mass (chief fundic cells and mucopeptic fundic-antral cells): cellular-secretory correlations in normal subjects].

The aim of this experience has been to evaluate cytosecretory correlations between total peptic activity in gastric juice and gastric peptic cell mass (chief cells and fundic-antral mucopeptic cells) in normal subjects. Gastric peptic cell mass and total peptic activity do not change depending on sex. Concerning age, in spite of a significant decrease of gastric peptic cell mass, peptic activity does not significantly decrease. This apparent disagreement between decreasing anatomic data and functional data, remaining unchanged, may be explained by analyzing the behaviour of fundic and antral peptic cell masses in detail. A difference emerges in the behaviour of chief and mucopeptic cells. The first decrease significantly after 50 years, while the second ones do not show variations, regardless of their fundic and antral location. In particular, fundic mucopeptic cell component increase, but not significantly. The lack of variation in peptic activity in gastric juice after 50 years may be assumed to be connected with the unchanged integrity of mucopeptic cells.

Adult↗
PubMed1995

[The parietal cell mass and acid secretion: Helicobacter pylori does not induce changes in the course of a duodenal ulcer].

Some studies have postulated that Helicobacter pylori (HP) itself might be responsible for hypergastrinemia and acid secretion in duodenal ulcer (DU). In each DU patient parietal cell mass (expressed by a parietal index) and stimulated acid secretion (expressed by maximal acid output) were evaluated. The study has been conducted grouping DU patients in relation to HP infection in antral mucosa. HP infection does not modify parietal cell mass and stimulated acid secretion. Therefore, mild chronic hypergastrinemia induced by HP infection is not sufficient to justify any increase of parietal index and acid secretion. In fact, parietal cells and acid secretion remain higher in DU subjects independently from HP infection.

Biopsy↗
PubMed1994

Epidemiology and etiology of "autonomous" nonspecific duodenitis.

In this prospective study we looked for possible epidemiological and etiological factors in "autonomous" nonspecific duodenitis. Of 136 dyspeptic patients who entered the study, duodenitis was found in 25.6% (94.4% chronic duodenitis and 5.6% isolated active duodenitis). Men predominated with a significant prevalence of 74%; 49% of them had white-collar jobs, but age, psychological factors, and the season of the year played no role. We found that smoking and alcohol and coffee intake bore no relation to duodenitis. Helicobacter pylori (HP) was present in only 17.1% of patients with duodenitis, little different from the 10% prevalence in dyspeptic patients without duodenitis. HP was always associated with gastric metaplasia and inflammatory activity.

Adult↗
PubMed1994

Serum pepsinogen A and pepsin secretion in duodenal ulcer: Helicobacter pylori influence.

Serum pepsinogen A (PGA) and total pepsin activity (PA) in gastric juice were investigated in 87 duodenal ulcer patients. The analysis of data shows a significant increase of PGA and PA in comparison with controls. The grouping of duodenal ulcer patients according to Helicobacter Pylori (HP) infection revealed in HP positive patients a significant increase of PGA, while PA does not change. This contrast may be due to various factors: in particular the two parameters are an expression of different cellular activities and the PA in gastric juice is expression of all pepsinogens. It can be concluded that the damaging action of HP on duodenal mucosa is due to a direct action and not related to alteration of pepsin activity in gastric juice. Moreover, serum PGA can be held as useful parameter of HP infection.

Adult↗
PubMed1994

[Total peptic activity in gastric juice in patients with duodenal ulcer. Variations in relation to age and role of Helicobacter pylori].

The aim of this study was to evaluate total peptic activity in gastric juice in duodenal ulcer patients in relation to age and Helicobacter pylori infection. In duodenal ulcer patients peptic activity increases significantly in comparison to normal subjects. In relation to age there is no variation. Therefore, gastric secretion has an autonomous behaviour independently of any physiological variation in healthy subjects. Helicobacter pylori infection is present in 89.4% of duodenal ulcer patients. The bacterium infection does not imply a significant increase of peptic activity in gastric juice. Its lesive action is therefore not attributable to a modification of peptic activity, but it is due to its direct action on gastric metaplasia in the duodenum.

Age Factors↗
PubMed1993

[The interferon treatment of chronic hepatitis C. Short- and long-term therapy and the problem of nonresponders].

The interferon therapy has represented a breakthrough in the treatment of chronic hepatitis. In this article we analyzed the results of short- and long-term therapy of hepatitis C, particularly referred to different dosage regimens and side effects. We paid particular attention to patients non responders to interferon therapy, for whom we reported the results obtained with the association of interferon and ursodeoxycholic acid, and with steroidal treatment.

Clinical Trials as Topic↗
PubMed1993

Gastric chief cell mass in duodenal ulcer.

Chief cell mass and serum Pepsinogen I were calculated in 25 duodenal ulcer patients and in 40 healthy controls. Comparisons were also made with parietal cell mass and the stimulated acid secretion. Chief cell mass was expressed bay a Zymogenous Index (ZI) obtained by multiplying the number of chief cells per mm2 for the thickness of the glandular layer. The analysis of the data shows a significant decrease of ZI in duodenal ulcer patients in comparison with controls. The grouping of the subjects according to the age (over and under fifty years), confirms that ZI decreases significantly in duodenal ulcer groups in relation with the respective groups of control. In case of duodenal ulcer with fundic superficial gastritis no behavioural changes of ZI are observed in comparison to those affected by duodenal ulcer with normal fundic mucosa. The serum Pepsinogen I significantly increases in duodenal ulcer patients in comparison to the controls, either in the subjects over and under fifty. In the group of duodenal ulcer patients with superficial fundic gastritis a significant increase of serum Pepsinogen I can be pointed out in comparison to the ulcer patients with normal fundic mucosa. The grouping of the patients on the basis of hyperparietalism and normoparietalism has shown in the former group hypozymogenism and in the latter normozymogenism. Finally, no correlation has emerged between Zymogenous Index and serum Pepsinogen I.

Adolescent↗
PubMed1993

[Peptic activity of gastric juice in chronic gastritis. Morpho-functional aspects].

The aim of this study has been to evaluate peptic activity in gastric juice and gastric peptic cell mass in chronic gastritis. As regard peptic activity, there is a close correlation between it and the peptic gastric cell mass considered globally and expressed as Peptic Gastric Index (PGI), resulting from the individual average between fundic peptic index (chief cells + fundic muco-peptic cells) and antral peptic index (antral muco-peptic cells), both obtained by multiplying the number of peptic cells per mm2 by the thickness of respectively fundic and antral gland layer). In particular fundic and antral superficiale gastritis does not involve changes in peptic activity in gastric juice. On the contrary, in case of fundic pre-atrophic or atrophic there is a significant drop of peptic activity in gastric juice, regardless of the histological condition of the antrum. The lowest value of peptic activity may be noticed in case of atrophic pan-gastritis. Pre-atrophic and atrophic gastritis limited to the antrum--with superficial fundic gastritis--does not involve significant decreases of peptic activity in gastric juice. In this experiences Helicobacter pylori seem to influence peptic secretion: in fact, there is an increases of peptic activity in gastric juice in case of chronic pre-atrophic gastritis HP+.

Adult↗