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Biomedical subjects

G Trigonidis

Publications and source records attributed to G Trigonidis.

At least 19 recordsLinked to original sources
PubMed1997

Malignant potential of oral lichen planus; a follow-up study of 326 patients.

326 patients with oral lichen planus were followed for periods ranging from 6 months to 10 years (mean 4.8 years), in an attempt to clarify the malignant potential of this disease which is still controversial. Malignant transformation occurred in 4 patients (1.3%) in a mean time of 6.5 years after the onset of lichen planus. Before cancer development, 3 of these patients manifested the erosive form of oral lichen planus, while the others, a combination of the papular/atrophic form. Malignant transformation in our patients could not be associated with any evident factors, such as family history, local irritation, alcohol consumption, nutritional disturbances or other systemic diseases.

Adolescent↗
PubMed1997

Granulomatous cheilitis: a study of six cases.

OBJECTIVE: Granulomatous cheilitis (GC) is a very rare disorder of unknown etiology. Clinically, GC is characterised by recurrent swelling of the labial tissues, which may be followed by a permanent enlargement. Histologically, the typical form of GC is characterised by the formation of scattered aggregates of non-caseating granulomas. GC is the most frequent sign of orofacial granulomatosis, a disorder under which also encompasses sarcoidosis, Crohn's disease, atypical tuberculosis, Anderson-Fabry disease, possibly some allergic reactions, and Melkersson-Rosenthal syndrome (MRS). Some consider GC as an oligosymptomatic or monosymptomatic form of MRS. SUBJECTS AND METHODS: In this study we examined the clinical records of six patients presenting with GC which were examined and treated in the Department of Oral Medicine and Pathology of the Dental School of Aristotle University of Thessaloniki (Greece) during a 16-year period. In five of six patients a persistent swelling of the lower lip was recorded, one of whom also developed swelling in the upper lip. In one case the swelling was present in both lips and in another the GC was the only clinical finding, while in the other five cases it was accompanied by at least one other feature of MRS. In five cases, the histological picture revealed non-caseating granulomas. RESULTS: The treatment with the intralesional infusion of corticosteroids in three cases and the oral administration of corticosteroids in two cases was successful. One of the patients refused to be treated. This patient also presented later with permanent swelling of the upper lip.

Adult↗
PubMed1996

Oral tuberculosis.

A case with oral tuberculosis and unaware of systemic tuberculosis is reported. The oral lesions clinically manifested as two painless ulcerations in the hard palate. Pulmonary tuberculosis was diagnosed following the histopathologic and bacteriologic examination of the oral lesions.

Aged↗
PubMed1996

Desquamative gingivitis: a clinical, histopathologic, and immunologic study.

Desquamative gingivitis is believed to be a clinical sign of certain mucocutaneous diseases rather than a distinct pathologic entity. The prevalence of desquamative gingivitis was studied in a group of patients with the most common mucocutaneous diseases. Of 414 patients with pemphigus vulgaris, mucous membrane pemphigoid, or oral lichen planus, 49 (11.8%) exhibited gingival lesions in the form of desquamative gingivitis. Desquamative gingivitis was most prevalent in the patients with mucous membrane pemphigoid (41.6%) followed by those with pemphigus vulgaris (9.1%). Other clinical characteristics, as well as histopathologic and immunohistochemical findings, that aid in early diagnosis are presented.

Adult↗
PubMed1995

Squamous cell carcinoma of the lips in a northern Greek population. Evaluation of prognostic factors on 5-year survival rate--I.

The purpose of this study was to determine the clinical features of squamous cell carcinoma (SCC) of the lips, along with its prognostic factors, in order to extend and update the information related to lip cancer in northern Greece and to provide a basis for international comparison. Records of 1510 patients with SCC of the oral cavity presented at the Theagenion Anticancer Institute of Thessaloniki, Greece from 1979 and 1989 were reviewed. The most common site for oral squamous cell carcinoma (OSCC) was found to be the lips (59.4%) as compared to 40.5% of intra-oral SCC. Males were affected more frequently, presenting a ratio of 9.2:1. The peak age of incidence was found to be the 6th decade for men and the 8th for women. Rural residents and outdoor workers were affected more than urban residents (79.9% versus 28.1%). Most of the patients were diagnosed in early categories and early clinical stages of the disease. Almost all (98.5%) were classified into T1 and T2 categories, and 92.9% into stages I and II. A total of 7.59% of patients presented with clinically-positive lymph-node involvement. Most of them were classified as an advanced stage of the disease. Primary surgical excision was performed on 60.14%, radiotherapy on 35.14%, a combination of these on 2.47%, and chemotherapy alone or in combination with the above regimens in 2.22% of the cases. The outcome was adequate for surgery, radiotherapy, and the combination of the two, since 91.3, 74, and 90%, respectively, survived for more than 5 years. An overall 5-year survival rate of 83.3% was found. Our findings showed that the survival rate was significantly influenced by the main prognostic factors, such as the size of the tumour, the lymph-node involvement, the clinical stage of the disease and the histologic differentiation. SCC of the lips continues to be the most common site of oral cancer development amongst the Greek population. The aetiologic significance of actinic radiation for SCC of the lips is confirmed by our findings. The main prognostic factors proved to significantly influence the survival of our patients. Our results support the fundamental principal of head and neck cancer, i.e. that early detection of the primary tumour is the best prognostic factor for increasing survival rates. Therefore, public awareness concerning the disease, and better education for health care workers which will provide a thorough knowledge for the prognosis of oral cancer and the factors influencing it, is necessary.

Adult↗
PubMed1994

The role of the time of application of the promoter in two-stage chemically induced carcinogenesis in the oral mucosa: experimental study in the rat.

The purpose of this study is to determine the role of the time of application of the promoter (in this case, mechanical irritation) in two-stage chemically induced oral carcinogenesis. One hundred fifty-five male rats were divided into seven groups. Group 1, 2 and 3 each received two intraperitoneal injections of the carcinogen N-nitroso-N-methylurea (NMU): 50 mg/Kg BW. Mechanical irritation was applied on the left buccal mucosa, 7 days before the first injection of NMU (group 1), 16 days (group 2), and 80 days (group 3) after the carcinogenic administration. Animals of groups 4, 5, 6 and 7 served as controls. Only group 1 and 2 animals developed tumors in the irritated buccal mucosa. From the results of this study we conclude that the delay of the application of the promoter does not lead to tumor formation. This could be explained by the repair of the carcinogenic lesion at the cellular level.

Animals↗
PubMed1994

Salivary gland tumors studied by means of the AgNOR technique.

Silver-binding nucleolar organizer regions (AgNORs) were counted in sections from formalin-fixed, paraffin-embedded tissue blocks of 14 benign and 17 malignant tumors of minor salivary glands. The difference in the mean number of AgNORs count per nucleus between benign and malignant tumors was found to be statistically significant (p < 0.001). A positive correlation between the AgNORs count and the degree of malignancy of the malignant salivary gland tumors was generally observed. The AgNORs technique can be used as a diagnostic aid in differentiating between benign and malignant salivary gland tumors, and possibly the salivary duct carcinoma from the acinic cell carcinoma and poorly differentiated mucoepidermoid carcinoma.

Adenocarcinoma↗
PubMed1994

Eosinophils in oral and cutaneous lesions of erythema multiforme.

The purpose of this retrospective clinicopathologic study was to investigate the presence of eosinophils in oral and skin lesions of erythema multiforme. Seventeen cases were selected which fulfilled clinical and histopathologic criteria for the disease. Twelve out of 13 sections taken from skin biopsies and 4 out of 5 sections taken from oral lesions contained eosinophils in varying densities. The occurrence of eosinophils in the lesions of erythema multiforme is parallelized and discussed with the existence of certain clinical and histopathologic aspects. Therefore, we suggest that eosinophils occur in cutaneous and oral lesions of erythema multiforme and are occasionally numerous.

Adult↗
PubMed1994

Kaposi's sarcoma of the oral cavity: case reports.

Classic Kaposi's sarcoma is a rare malignant neoplasm of endothelial cell origin. Oral manifestation of Kaposi's sarcoma is even more uncommon. The purpose of this article is to describe two cases of classic Kaposi's sarcoma and to discuss the current knowledge regarding its pathogenesis, epidemiology, clinical characteristics, and therapy.

Aged↗
PubMed1991

Primary tuberculosis of the oral cavity.

Two cases of primary tuberculosis of the mouth are reported. Painless ulceration of long duration and enlargement of the regional lymph nodes that did not respond to conservative and antibiotic therapy were the main manifestations of the disease in both cases. In the first case the tubercle ulcer was located in the lower buccogingival sulcus of a 17-year-old girl. In the second case the lesion occurred as a chronic periodontal inflammation around the gingiva of the left lower second molar tooth. When the tooth was extracted, a painless ulceration appeared around the socket, which was filled by granulation tissue. Histopathologic examination; bacteriologic, serologic, and blood tests; and chest x-ray film confirmed the diagnosis. Predisposing factors that might favor primary inoculation of tubercle bacilli into oral mucosa are also discussed. Finally we emphasize that in such cases it is essential to attempt to locate a possible primary site elsewhere in the body before oral tuberculosis is considered the primary disease.

Adolescent↗
PubMed1990

[Ultrastructural and histochemical study of a pleomorphic adenoma of the palate].

Histochemical and ultrastructural study of the epithelial regions forming lumina in one case of pleomorphic adenoma of the palate was undertaken. The ultrastructural findings suggest that these epithelial regions are derived from the intercalated ducts. The presence in the cytoplasm of periluminal cells of pinocytotic vesicles and vacuoles containing material similar in appearance of that seen in the luminal supports a reabsorptive activity of these cells. The microcalculi of calcium phosphate occasionally seen in the cytoplasm of these cells may be formed by the phagocytosis of the endocytotic material from the lumina.

Adenoma, Pleomorphic↗
PubMed1990

[Chondrosarcoma: review of the literature and report of a case located in the maxilla].

Chondrosarcomas of the jaws and facial region are very rare tumors when compared with other bony tumors. It may show growth for several months or it may present as a rapidly growing tumor causing facial deformity, nasal obstruction, epistaxis, visual disturbances and teeth dislocation. Tumor radiologic evaluation must be done very carefully with conventional techniques, CT or M.R. Treatment must be surgical with wide an block excision. Treated patients should have a long-term follow up, because may recur, even after years.

Chondrosarcoma↗
PubMed1990

[Lithiasis in small salivary ducts. Report of 3 cases].

Three cases with sialolithiasis of minor salivary gland are presented. The sialoliths were found on the left side of the upper lip (two patients) with local infection and on the right side of buccal mucosa (one patient) without any symptom. The histologic findings resulted from our own cases and the etiology are discussed extensively and a literature review is made as well.

Aged↗
PubMed1990

Submucous dirofilariasis involving the cheek. Report of a case.

Dirofilariasis is characterized by the presence of numerous filarial worms in the subcutaneous tissues, and by the formation of subcutaneous nodules. The clinical symptoms and histologic features of the disease are discussed, together with a case report from Greece.

Cheek↗