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G Turchetti

Publications and source records attributed to G Turchetti.

At least 19 recordsLinked to original sources

Multiple returns for some regular and mixing maps.

We study the distributions of the number of visits for some noteworthy dynamical systems, considering whether limit laws exist by taking domains that shrink around points of the phase space. It is well known that for highly mixing systems such limit distributions exhibit a Poissonian behavior. We analyze instead a skew integrable map defined on a cylinder that models a shear flow. Since almost all fibers are given by irrational rotations, we at first investigate the distributions of the number of visits for irrational rotations on the circle. In this last case the numerical results strongly suggest the existence of limit laws when the shrinking domain is chosen in a descending chain of renormalization intervals. On the other hand, the numerical analysis performed for the skew map shows that limit distributions exist even if we take domains shrinking in an arbitrary way around a point, and these distributions appear to follow a power law decay of which we propose a theoretical explanation. It is interesting to note that we observe a similar behavior for domains wholly contained in the integrable region of the standard map. We also consider the case of two or more systems coupled together, proving that the distributions of the number of visits for domains intersecting the boundary between different regions are a linear superposition of the distributions characteristic of each region. Using this result we show that the real limit distributions can be hidden by some finite-size effects. In particular, when a chaotic and a regular region are glued together, the limit distributions follow a Poisson-like law, but as long as the measure of the shrinking domain is not zero, the polynomial behavior of the regular component dominates for large times. Such an analysis seems helpful to understand the dynamics in the regions where ergodic and regular motions are intertwined, as it may occur for the standard map. Finally, we study the distributions of the number of visits around generic and periodic points of the dissipative Henon map. Although this map is not uniformly hyperbolic, the distributions computed for generic points show a Poissonian behavior, as usually occurs for systems with highly mixing dynamics, whereas for periodic points the distributions follow a different law that is obtained from the statistics of first return times by assuming that subsequent returns are independent. These results are consistent with a possible rapid decay of the correlations for the Henon map.

Algorithms↗

Statistics of Poincaré recurrences for maps with integrable and ergodic components.

Recurrence gives powerful tools to investigate the statistical properties of dynamical systems. We present in this paper some applications of the statistics of first return times to characterize the mixed behavior of dynamical systems in which chaotic and regular motion coexist. Our analysis is local: we take a neighborhood A of a point x and consider the conditional distribution of the points leaving A and for which the first return to A, suitably normalized, is bigger than t. When the measure of A shrinks to zero the distribution converges to the exponential e(-t) for almost any point x, if the system is mixing and the set A is a ball or a cylinder. We consider instead a system, a skew integrable map of the cylinder, which is not ergodic and has zero entropy. This map describes a shear flow and has a local mixing property. We rigorously prove that the statistics of first return is of polynomial type around the fixed points and we generalize around other points with numerical computations. The result could be extended to quasi-integrable area preserving maps such as the standard map for small coupling. We then analyze the distribution of return times in a region which is composed by two invariants subdomains: one with a mixing dynamics and the other with an integrable dynamics given by our shear flow. We show that the statistics of first return in this mixed region is asymptotically given by the exponential law, but this limit is attained by an intermediate regime where exponential and polynomial laws are linearly superposed and weighted by some factors which are proportional to the relative sizes of the chaotic and regular regions. The result on the statistics of first return times for mixed regions in the phase space can provide a basis to analyze such a property for area preserving maps in mixed regions even when a rigorous result is not available. To this end we present numerical investigations on the standard map which confirm the results of the model.

Algorithms↗

Chronic antigenic stress, immunosenescence and human survivorship over the 3 last centuries: heuristic value of a mathematical model.

In previous investigations we pursued the hypothesis that lifelong, chronic antigenic load (CAL) is the major driving force of immunosenescence, which impacts on human lifespan by reducing the number of virgin antigen-non experienced (ANE) T cells, and filling the immunological space with expanded clones of memory and effector, antigen-experienced (AE) T cells. A model has been proposed to relate CAL with the conversion rate from ANE to AE CD8+ T cells. In addition, in order to account for individual variations of immunosenescence and lifespan, a noise term has been introduced to describe the individual fluctuations of CAL. This model was able to follow with a reasonable approximation the age-related decrease of ANE CD8+ T cells, as well as human survival curves. In this paper we extend this approach to historical survival curves, starting from 1750 until present days, and show that the quality of the fit of historical demographic data improves as we approach the recent, quantitative and qualitative decrease of CAL. Indeed, the almost linearity in the increase of lifespan and in the decrease of the noise fluctuation amplitude within this historical period suggests that the improvement of life conditions has steadily lowered the intensity of CAL and restricted the variability which results from the interaction between the individuals and their immunological environment. On the whole, this approach allows to appreciate when and how immunosenescence has started to impact on survivorship, and predicts its increasing, crucial role in explaining human mortality in hygienized, economically developed societies.

Aging↗

A stochastic model for CD8(+)T cell dynamics in human immunosenescence: implications for survival and longevity.

We propose here a stochastic model for the CD 8(+)T lymphocyte dynamics on the long time-scale of the human lifespan. Our purpose has been to test the hypothesis, recently proposed on the basis of our experimental data (Fagnoni et al., 2000), that the depletion of virgin CD8(+)T lymphocytes can be considered a reliable biomarker related to the risk of death. This hypothesis is embedded in a more general theory of immunosenescence according to which the accumulation of antigen experienced (AE) T cells and the concomitant exhaustion of antigen non-experienced (ANE) T cells with age, mostly due to the chronic lifelong exposure to antigens, is a major characteristic of the remodeling of the human immune system with age. In our model we considered a deterministic balance of ANE and AE T cell concentrations plus a stochastic forcing, which describes the chronic antigenic stress fluctuations, assuming a mean genetically determined capability of individuals to respond to antigens. The major results of our model is the validation of the above-mentioned hypothesis, since the model is capable of fitting the experimental data concerning the changes of ANE T cell concentration over age, and at the same time to reproduce survival curves similar to the demographic ones. Furthermore, the stochastic process results in being responsible for the peculiar shape of the survival curves.

Aging↗

Elevated basal insulin secretion and normal dynamic insulin sensitivity in borderline hypertension.

BACKGROUND AND AIM: Borderline hypertension is often the initial stage of stabilized hypertension. This study aimed to provide insight on insulin behavior and its relationship with glucose metabolism by investigating insulin secretion and hepatic clearance in non-steady-state conditions in borderline hypertensive patients. METHODS AND RESULTS: We studied 15 patients (6 F, 9M, 44 +/- 2 yr, 78 +/- 2 kg, systolic pressure 155 +/- 10 mmHg, diastolic 93 +/- 5) and 15 comparable healthy controls. All underwent an intravenous glucose test, with minimal model analysis to measure insulin sensitivity S1, glucose effectiveness SG, insulin pre-hepatic release, hepatic extraction, and insulin appearance rate in the systemic circulation. Basal glucose (3.98 +/- 0.12 vs 3.94 +/- 0.11 mmol/L, hypertensive vs control subjects respectively), i.v. glucose tolerance factor KG (2.0 +/- 0.2 vs 2.2 +/- 0.1% min-1), SG (0.035 +/- 0.004 vs 0.032 +/- 0.007 min-1) and S1 [3.5 +/- 0.5 vs 3.8 +/- 0.3 10(4) min-1 (microU/mL)] were similar, both basal insulin and C-peptide exhibited a marked increase (87 +/- 8 vs 46 +/- 6 pmol/L, p = 0.0003; 637 +/- 62 vs 381 +/- 76 pmol/L, p < 0.03) demonstrating insulin resistance in basal conditions. Insulin secretion per unit volume was greater in patients, both at basal (43 +/- 5 vs 24 +/- 5 pmol/L/min, p = 0.01) and after stimulation (total hormone released = 18 +/- 2 vs 11 +/- 2 nmol/L in 4 h, p = 0.022). Post-hepatic insulin delivery was also elevated (basal = 11 +/- 1 vs 6 +/- 1 pmol/L/min, p < 0.002, total = 5 +/- 1 vs 3 +/- 0.3 nmol/L in 4 h, p = 0.02), while no difference was detected in hepatic extraction (66 +/- 4% vs 66 +/- 3). CONCLUSION: Borderline hypertensive patients display normal glucose tolerance with basal insulin resistance and normal dynamic insulin sensitivity. Peripheral hyperinsulinemia derives from the combination of normal hepatic extraction with an overproduction of hormone, mostly due to the basal component. Because borderline hypertension often degenerates into overt disease, our results point to a progression that leads to the well-known insulin resistance proper to sustained hypertension.

Adult↗

[Isolated aneurysm of the interatrial septum. Description of a clinical case and review of the literature].

The aneurysm of the interatrial septum (ASA) is a rare congenital heart disease, easily recognizable by real time cross sectional two dimensional echocardiography. The ASA occurs as an isolated entity or may be associated with congenital heart disease. Usually ASA may cause serious complications such as embolic phenomena, atrial or ventricular tachyarrhythmia and eventually following a rupture or atrial shunt. The Authors a case of 44-year-old woman referred to hospital for a paroxysmal supraventricular tachyarrhythmia and found to have an ASA as isolated anomaly.

Adult↗

Streptococcus faecalis susceptibility to amiloride depends on medium pH.

Amiloride is one of the major molecular probes in basic and applied investigations on the physiology of cation transport in animal cells. In these cells the drug also exerts growth inhibitory activity. Recently, we discovered that amiloride causes growth inhibition also on bacterial cells. In this paper we report that medium pH influences amiloride activity on Streptococcus faecalis. The lowering of external pH causes a drop in the susceptibility of this bacterium to amiloride up to an almost complete resistance. This finding, constitutes a novel aspect of the in vitro experimental pharmacology of this diuretic potentially useful also in clinical pharmacology and in animal cell investigations.

Amiloride↗

In vitro antistreptococcal activity of the potassium-sparing diuretics amiloride and triamterene.

The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent cation fluxes on animal cells possesses a selective growth-inhibitory activity on hemolytic streptococci.

Amiloride↗