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Biomedical subjects

G U Coleman

Publications and source records attributed to G U Coleman.

11 recordsLinked to original sources
PubMed1990

Augmentation ileocystoplasty in children with myelodysplasia.

Over the past 8 years 20 children suffering from myelodysplasia were selected to undergo augmentation ileocystoplasty for urinary incontinence refractory to treatment by clean, intermittent catheterization and anticholinergic agents, or as part of urinary undiversion. The children ranged in age from 5 to 17 years, and the follow-up ranged from 6 months to 7 years. Three children underwent undiversion, two had vesicostomy closure and six had bladder outlet repair at the time of augmentation. In one patient, surgery was technically impossible. Postoperatively 16 children were fully continent on clean, intermittent catheterization and anticholinergic medication. Three boys failed to achieve satisfactory continence. Delayed perforation, a potentially serious complication, occurred in two patients several months postoperatively.

Adolescent↗
PubMed1989

Wilms tumorlet, nodular renal blastema and multicystic renal dysplasia.

We reviewed 60 cases of multicystic renal dysplasia collected during a 10-year period. Differentiated nonproliferative nodular renal blastema occurred in 6.7 per cent of the cases, which is similar to the incidence of nodular renal blastema in kidneys of other infants with congenital obstructive uropathy. A unique case of cystic dysplasia containing nodular renal blastema and Wilms tumorlet indicates the possibility that a persistently proliferative nephroblastomatous lesion may rarely occur.

Child↗
PubMed1988

Dicentric Y chromosome and mixed dysgenesis.

We report 4 cases of mixed gonadal dysgenesis with a karyotype containing a dicentric Y chromosome. All cases were mosaic with 45X and 46X, dic(Y) cell lines. Of the patients 1 had ambiguous genitalia and some features of Turner's syndrome, 2 had classical features of Turner's syndrome with normal female external genitalia and 1 had no features of Turner's syndrome but he presented with penoscrotal hypospadias, inguinal hernia and cryptorchidism. Female gender assignment and early total gonadectomy should be considered when a dicentric Y chromosome is present in cases of mixed gonadal dysgenesis.

Child, Preschool↗
PubMed1988

Clinical follow-up of fetal urinary tract anomalies diagnosed prenatally by ultrasound.

This retrospective review identified 122 cases with a prenatal diagnosis of genitourinary anomalies and categorized them into parenchymal and collecting system abnormalities. Comparisons were made between the anatomical groups for indications for ultrasound, average gestational age at positive and negative renal ultrasound diagnosis, amniotic fluid volume and pregnancy outcome with postnatal diagnosis. The results indicated that parenchymal abnormalities were detected earlier in gestation than collecting system anomalies. Additional fetal anomalies were more often present in the parenchymal group. Chromosome abnormalities were present in 5% of the urinary tract abnormalities. Parenchymal abnormalities were more likely to have oligohydramnios and a higher morality rate.

Female↗
PubMed1988

Bladder-outlet reconstruction in neurogenic bladder due to myelomeningocele.

In a subgroup of children with myelomeningocele, urinary incontinence cannot be managed by clean intermittent catheterization and anticholinergic medication. The authors report on 24 such children who required bladder-outlet reconstruction. Twelve boys underwent the Young-Dees/Leadbetter procedure, 8 girls underwent the Burch procedure and the remaining 4 had a combination of the two. Augmentation cystoplasty was also carried out in seven girls and one boy. Results were most favourable in the girls, with improvement in 92%, in contrast to the boys in whom only 58% were improved. Artificial sphincter placement may be a more beneficial alternative for boys.

Adolescent↗
PubMed1987

Neonatal renomegaly.

A retrospective clinical review was done to study the value of ultrasound and renography in the investigation of 100 neonates with renomegaly. Abnormalities in 73 patients were detected antenatally with ultrasonography. Of the neonates 47 had lower urinary tract pathological conditions and ultrasound was more than 90 per cent accurate in identifying the accompanying ureteral dilatation. A total of 53 neonates had upper tract anomalies (ureteropelvic junction obstruction or cystic dysplasia). With ultrasonography the degree of pyelocaliectasis in patients with ureteropelvic junction obstruction was classified as mild (22 units), moderate (13) or severe (7). Initial treatment and followup were reviewed to study the clinical course of neonates with mild to moderate degrees of pyelocaliectasis followed nonoperatively, and to determine whether the diuretic renogram had a predictive role in identifying which kidneys were most likely to deteriorate.

Dilatation, Pathologic↗
PubMed1985

Megalourethra.

We present 5 examples of megalourethra. All 5 cases were associated with the spectrum of the triad syndrome, ranging from minor hydronephrosis and undescended testis to gross hydronephrosis incompatible with survival. Initial management of this urethral defect is drainage followed later by reconstruction.

Child, Preschool↗
PubMed1975

Solitary epididymal schistosomiasis.

A 54-year-old Canadian presented with a 1-month history of painless swelling in the right testis. The diagnosis was thought to be a sperm granuloma, a leiomyoma, or an adenomatoid tumour of the epididymis; histologic examination, however, revealed evidence of schistosomiasis, probably due to Schistosoma haematobium. Solitary schistosomiasis of the epididymis has been reported previously in only two cases. Epididymal schistosomiasis has never been diagnosed preoperatively because it is so rare, but even if it were suspected preoperatively and confirmed by biopsy, chemotherapy alone would not prevent impairment of epididymal function due to scarring. Surgical excision of the lesion, therefore, is recommended.

Adult↗