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Biomedical subjects

G U Fisher

Publications and source records attributed to G U Fisher.

17 recordsLinked to original sources
PubMed1985

Photodynamic therapy in otolaryngology--head and neck surgery.

Photodynamic therapy utilizes a photosensitizing drug, hematoporphyrin derivative, and laser light to diagnose and treat cancer. We used treatment and diagnostic instrumentation and techniques developed during the last seven years to treat 31 patients over the last two years. Diffuse, superficial tumors of the head and neck responded well to photodynamic therapy as did localized bulk lesions of this area. Photodynamic therapy achieved initial control in patients with early lung cancer and opened up bronchi in those with obstructive lung cancer. Widespread, bulky tumors responded inconsistently. Neck metastases responded poorly when treated for tumor control. The beneficial effects of phototherapy and its general lack of severe complications may, however, warrant its use for limited palliative goals in the patient with far-advanced head and neck cancer, especially when irradiation and surgery have failed.

Basal Cell Carcinoma↗
PubMed1981

Left ventricular pseudoaneurysm secondary to infection after coronary bypass surgery.

We present a case of left ventricular pseudoaneurysm following coronary bypass surgery. The cause was infection, dating from the bypass procedure 1 1/2 years before. Repair of pseudoaneurysm in a patient with a bypass is complicated by the presence of grafts which should be protected from injury. Details of successful management in this case are presented.

Coronary Artery Bypass↗
PubMed1980

Spontaneous closure of residual ventricular septal defect following surgical repair of ventricular septal defect complicating acute myocardial infarction.

Spontaneous closure of ventricular septal defects in patients with congenital heart disease is well documented. Also, successful closure of ventricular septal defects complicating myocardial infarction performed in the acute phase have been reported, although the mortality rate is high. Intra-aortic balloon pumping has been helpful in this regard, as it was in our patient. Our case is of interest in that it demonstrates the possibility of spontaneous closure of a residual ventricular septal defect resulting from rupture of the interventricular septum, secondary to acute myocardial infarction, partially closed at surgery. Clearly, the residual defect was small in that the patient was substantially benefitted by surgery and the postoperative catheterization revealed a small 5% step-up in oxygen saturation at the right ventricular level.

Heart Septal Defects, Ventricular↗
PubMed1970

Plasmodium ovale malaria acquired in Viet-Nam.

Four cases of Plasmodium ovale malaria are reported among US servicemen stationed in Viet-Nam between January 1966 and March 1969. Taken together with other cases cited by the authors, these provide strong evidence of the existence (sometimes disputed) of this Plasmodium in continental South-East Asia.None of the men had served in any other area of endemic malaria and their travel and medical histories suggest that all 4 infections were acquired by mosquito transmission. They constitute only 0.066% of the 6036 malaria cases reported among servicemen returning from Viet-Nam during this period and represent only 0.11% of the blood films from 3686 individuals examined at the US National Malaria Repository during the same period.Serological testing for malaria antibodies with the indirect fluorescent technique corroborated the diagnosis of P. ovale in 1 case. Speciation was not possible in the other 3 cases since titres to P. vivax and P. ovale antigens were identical. Only 1 of the patients reported previous experience with vivax malaria.Most of the parasites seen in thin blood films were developing trophozoites and immature schizonts; ring forms and gametocytes were rare; mature schizonts were not found. The morphology of the parasites was typical of P. ovale, with more than 50% of the infected cells showing fimbriations, an oval shape or both.

Adult↗