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G Ueda

Publications and source records attributed to G Ueda.

At least 127 records · Page 7Linked to original sources
PubMed1984

[Immunohistological study on the histogenesis and malignant transformation of ovarian mucinous tumors, with special reference to the intestinal metaplasia].

Mucinous tumors of the ovary are generally considered to have a dual origin in histogenesis. Teratomatous elements, however, have recently been reported as appearing in a process of intestinal metaplasia. Malignant transformation has also been felt to occur through intestinalization. To clarify the matter, the relationships among morphological changes in intestinalization, carcinoembryonic antigen and mucus antigens named IMA and M1, which were isolated from intestinal mucosa and ovarian mucinous cyst fluid respectively, were studied in 4 benign, 8 borderline and 6 malignant mucinous tumors of the ovary. Intestinal type and goblet- like cells were sparse, if any, in benign tumors, but conspicuous in borderline and malignant ones. Carcinoembryonic antigen was located in the glycocalyx of intestinal type cells in the benign tumors, but distributed over the entire cytoplasm increasingly with malignancy. These findings lend support to the theory that malignant transformation may occur through intestinal metaplasia in mucous tumors. M1 was positive in many cells of all mucinous tumors, but IMA was shown in some goblet-like cells of a few tumors, regardless of malignancy or the presence of argyrophil cells. These phenomena could be best understood by postulating that IMA was located in the teratomatous intestinal goblet cells of the tumors.

Antigens, Neoplasm↗
PubMed1984

Immunohistological study of isoantigens, carcinoembryonic antigen and human chorionic gonadotropin in adenocarcinomas of the uterus.

Isoantigens, carcinoembryonic antigen (CEA) and human chorionic gonadotropin (hCG) were simultaneously studied by immunohistology in the cervical and endometrial adenocarcinomas. Isoantigen loss was observed in all adenocarcinoma in situ (AIS) of the uterus. However, they appeared again in some tumor cells in 8 of 23 cervical and 4 of 41 endometrial adenocarcinomas. CEA was positive in 1 of 4 AIS and 22 of 23 adenocarcinomas of the cervix. It was distributed continuously in the apical portion and/or in the whole cytoplasm of tumor cells. On the other hand, CEA was positive only in 16 of 41 endometrial adenocarcinomas. It was strongly positive in the squamous elements, but weakly and sparsely in the apical portion and/or in the cytoplasm of some isolated glandular cells which occasionally showed a tendency to squamous differentiation. The majority of neoplastic glands, however, were negative for CEA. HCG was positive in 1 of 23 cervical and 3 of 41 endometrial adenocarcinomas. Two or 3 antigens were found concomitantly in some tumors, but localized differently from each other. It was concluded from the present study that the simultaneous examination of multiple antigens may be useful for characterization of adenocarcinomas of the uterus.

Adenocarcinoma↗
PubMed1984

[The clinical significance of tissue polypeptide antigen (TPA) in the patients with gynecologic tumor].

In order to estimate the clinical significance of tissue polypeptide antigen (TPA), TPA was measured by radioimmunoassay in sera from patients with various gynecological tumors. They were 40 uterine myomas, 94 cervical cancers, 21 endometrial cancers, 3 vulval cancers, 51 benign ovarian tumors and 78 malignant ovarian tumors including 18 low potential malignant tumors (LPM). The mean TPA values in patients with benign as well as malignant tumors were significantly higher than that of 97 healthy volunteers (68 +/- 17 U/l; Upper limit; 107 U/l). Among the cervical cancer patients, serum TPA level and positive ratio became higher as the disease progressed. In the advanced cases, the mean serum TPA value and positive ratio were 149 +/- 64 U/l and 75%, respectively. The mean TPA value in the endometrial cancer patients was significantly higher than that of myoma patients. Among the patients with ovarian tumor, serum TPA was elevated in 14% of benign cases, 28% of LPM cases, 47% of stage I cases and 82% of the advanced cases. Serum TPA values varied directly with the stage and malignancy of disease. The present study revealed that TPA is a useful markers in the diagnosis of gynecological tumors, especially for ovarian cancers.

Adenocarcinoma↗
PubMed1983

Dopamine-producing endometrial carcinoma with argyrophilia.

A case of moderately differentiated adenocarcinoma with argyrophilia arising in the endometrium of a 58-year-old Japanese woman is reported. Although she showed no endocrine symptoms, neuro-secretory granules were documented in the cytoplasm of some tumor cells by electron microscopy. Moreover, dopamine production by the tumor was demonstrated by biochemical determination. The possible mechanism accounting for such a lesion is discussed.

Adenocarcinoma↗
PubMed1983

Immunoreactive pancreatic secretory trypsin inhibitor in gynecological diseases.

Serum immunoreactive pancreatic secretory trypsin inhibitor in 45 patients with various gynecological diseases was measured by a radioimmunoassay. In normal serum of healthy individuals, the concentration was 11.7 +/- 2.3 ng/ml (mean +/- SD). Elevated levels (above control mean plus 3 S.D.) were observed in sera of 5 patients (50%) with ovarian cancer, and serum of one patient (4.7%) with uterine cancer. Only one tumor extract of ovarian cancer contained a significant level of immunoreactive PSTI. PSTI-containing mucin was detected in a mucin-producing ovarian adenocarcinoma.

Amylases↗
PubMed1983

[A study of T gamma cells in the regional lymph nodes of patients with uterine cervical cancer].

T gamma cells in peripheral blood and regional lymph nodes of 9 patients with uterine cervical cancer were studied. The results obtained were as follows: 1) The ratio of T gamma to total T lymphocytes in the peripheral blood was 12.2 +/- 3.2% in patients with uterine cervical cancer, being 11.2 +/- 2.3% at stage I and 14.5 +/- 3.8% at stage II, respectively. This value is not statistically different when compared with that of healthy donors. 2) The ratio of T gamma to total T lymphocytes of regional lymph nodes was 3.2 +/- 1.5%, much less than that of peripheral blood and showing that there were few T gamma cells in regional lymph nodes of patients with uterine cervical cancer. 3) T gamma cells were very few even in the regional lymph nodes with metastasis as well as without metastasis. These results are very interesting in connection with the immunological role of regional lymph nodes, but the significance requires further investigation.

Concanavalin A↗
PubMed1983

[Large granular lymphocytes (LGL) in the peripheral blood of patients with gynecological malignancies].

Large granular lymphocytes (LGL) containing almost all natural killer (NK) and killer (K) cells were studied in the peripheral blood of patients with gynecological malignancies. The results obtained were as follows: The ratio of LGL/peripheral blood lymphocytes (PBL) in normal volunteers was almost the same as that in patients with benign gynecological tumors, showing a tendency to increase, though not significantly, with age. The ratio of patients with precancerous disease or preinvasive cancer, including severe dysplasia, CIS and endometrial atypical hyperplasia, decreased more slightly than that of controls. On the other hand, that of patients with invasive malignant tumors, including uterine cervical cancer, endometrial cancer, uterine sarcoma, ovarian cancer and vulval cancer, increased significantly more than that of controls. The ratio showed no significant variation due to the difference in tumor sites and clinical stages Ia to III of cervical cancer. Out of 8 patients with ovarian cancer, 6 showed an extraordinarily high LGL/PBL ratio. It is concluded from the present study that the increase in the LGL/PBL ratio may be used as a new criterion in diagnosing invasive malignancies, including ovarian cancer, although the significance of the changing ratio still remains to be clarified.

Adult↗
PubMed1983

[Living cytology in the diagnosis of malignant ovarian tumor].

Atypical mesothelial cells are sometimes hard to differentiate from cancer cells in the cytology of ascitic or peritoneal washing fluid. The morphological characteristics of the cells, with or without the application of special stains, have mainly been used in differential diagnosis. In the present study, the living cytology described by Monif et al. is applied to the ascites of ovarian cancer patients. 13 cases of ovarian cancer with ascitic fluid were investigated. When 20-30ml ascitic fluid is cultured for a short term, the mesothelial cells transform to fibroblastic cells, and cancer cells form the special islets of cells. This phenomenon is judged as "Positive". The morphology of the ascitic smear and tissue culture of the tumor were also studied for comparison. Living cytology gave the same results as ascitic smear, and made it easier to differentiate mesothelial cells from cancer cells. Cancer cells in living cytology were similar to cells in tissue culture microscopically. In conclusion, living cytology seems useful especially when it is felt difficult to make a diagnosis of cancer cells on the basis of the contamination of active mesothelial cells.

Adenocarcinoma↗
PubMed1982

Immunohistological study of mucous antigens in gynecologic tumors with special reference to argyrophil cells.

Mucinous tumors of the ovary and adenocarcinomas of the female genital tract with or without argyrophil cells were studied by immunohistology for mucous antigens. These were isolated from intestinal mucosa and ovarian mucinous cyst fluid. Mucous antigen, M1 which is primarily associated with ovarian mucinous cystadenoma, was found in all mucinous tumors of the ovary, adenocarcinoma of the cervix, and endometrium. Intestinal mucous antigen (IMA), which is specific for goblet cells of the normal intestinal mucosa, was detected only in a few mucinous tumors of the ovary, with or without argyrophil cells. It was concluded that, while M1 was common to glandular gynecologic neoplasms, no special relationship existed between IMA and argyrophil cells in tumors of the ovary, endometrium, and endocervix.

Adenocarcinoma↗
PubMed1982

Endometrial argyrophil cell adenocarcinoma with indole- or catecholamine precursor uptake and decarboxylation.

The capacity for indole- or catecholamine precursor uptake and decarboxylation of the argyrophil cell adenocarcinoma of the endometrium was examined by fluorescence microscopy, microspectrofluorometry, and biochemical analyses. Both argyrophil and nonargyrophil cell adenocarcinomas of the human endometrium have been grown serially in nude mice. With the use of the formaldehyde-induced wet-histofluorescence method, yellowish green fluorescence was demonstrated in the cytoplasm of some cells of the argyrophil cell adenocarcinomas after exposure in vitro and in vivo to L-dopa. When 5-hydroxytrytophan was administered in vitro and in vivo to these tumors, an intense yellow fluorescence was also obtained in the cytoplasm. These fluorescent products were located in the argyrophil cells and corresponded to argyrophil granules. Microspectrofluorometrical and biochemical analyses strongly suggested that the yellowish green fluorescent products were dopamine and the yellow ones were serotonin, produced by decarboxylation of each amine precursor.

APUD Cells↗
PubMed1982

Hemodynamic responses to prostacyclin (PGI2) in the conscious sheep.

Hemodynamic responses to prostacyclin (PGI2) were studied in sheep in the conscious state as well as under pentobarbital-halothane anesthesia. PGI2 in doses of 0.02-1.0 microgram/kg were administered as a bolus into the right or left atrium in the conscious sheep. PGI2 decreased systemic arterial pressure (PSA), systemic (SVR) and pulmonary vascular resistance (PVR) and increased cardiac output (CO) and heart rate (HR) in a dose-dependent manner. The changes of each parameter were almost similar regardless of the sites of administration. Pulmonary arterial pressure (PPA) was increased. There was no change in left (PLA) or right atrial pressure (PRA). A bolus administration of 0.5 microgram/kg of PGI2 in the anesthetized sheep produced a decrease in PSA, SVR and PVR, and increase in CO and HR. PPA remained unchanged when administered into the right atrium and increased slightly when administered into the left atrium. PLA and PRA did not change. Comparing hemodynamic responses to 0.5 microgram/kg of PGI2 of the conscious and anesthetized states, decrease in PSA was smaller and increases in CO and HR were greater in the former. Decreases in SVR and PVR were similar in both states. Increase in PPA was greater in the conscious sheep. This data confirms that PGI2 dilates the systemic as well as the pulmonary circulation of the sheep and an inactivation of this compound in the lungs is minimal. Furthermore, it may be suggested that general anesthesia significantly alters hemodynamic responses to PGI2 in the sheep.

Animals↗
PubMed1982

Effects of amine precursor administration on the morphological findings of transplanted argyrophil cell adenocarcinoma of the endometrium.

Argyrophil cell adenocarcinoma of the endometrium has been kept serially in nude mice. Histological appearances of the tumor were not much changed by transplantations. Argyrophil granules were located mainly in the apical portion of glandular tumor cells in the transplanted tumors as in the original one. However, the cells with argyrophil granules in the entire cytoplasm were made conspicuous after the administration of L-DOPA. These results may suggest the existence of latent APUD cells in the argyrophil cell adenocarcinoma of the endometrium which are activated by the treatment of amine-precursor.

Adenocarcinoma↗
PubMed1982

[Clinicopathological study of ovarian embryonal carcinoma (Higuchi-Kato)].

Prognoses of embryonal carcinoma (Higuchi-Kato) of the ovary are extremely poor, and new modalities of the treatment are desired. In the present paper, we describe a clinicopathological study of ovarian embryonal carcinoma (Higuchi-Kato) with special references to the treatment and prognosis. 1) The patients examined were 20 in all, 8 belonging to embryonal carcinoma (Higuchi-Kato) Group A, 6 to the Group B, and 6 to the Group C. 2) The median age of patients was 20 years old. 3) The development of tumor was unilateral in all patients but one unsettled. 4) One patient was pregnant when the tumor was discovered. 5) The prognoses of patients in Group C were better than those of others. 6) Serum AFP is a good tumor marker, correlating well with the clinical courses of the patients. 7) To maintain ovarian function of young patients in stage Ia, unilateral adnexectomy with contralateral wedge resection and postoperative intensive chemotherapy are considered to be a choice of treatment method.

Adolescent↗