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Biomedical subjects

G Uhlschmid

Publications and source records attributed to G Uhlschmid.

At least 37 records · Page 2Linked to original sources
PubMed1986

Intracolonic migration of a pacemaker generator.

Following pacemaker implantation, a 75-year-old male developed a low grade infection of the generator pocket. Utilizing the same generator, several relocations of the generator were made with the result that eventually the pacemaker, eroding the muscular planes, found his way into the ascending colon. Healing could be achieved only after removing the whole pacemaker system. The authors' current policy in case of pacemaker infection is also reported.

Aged↗
PubMed1984

Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.

To evaluate the influence of inhibitors of prostaglandin synthesis on the incidence of DMH-induced colon cancer, 90 male Sprague-Dawley rats were randomly assigned to: indomethacin 20 mg per liter drinking water, meclofenamate 50 mg per liter drinking water, or normal drinking water (control group). Dimethylhydrazine was given by weekly subcutaneous injections (20 mg/kg body weight) during the first 20 weeks. Thirty-two weeks after the start of treatment and carcinogen exposure, the animals were killed and examined for the number, size, location, and spread of intestinal tumors. Colon cancer incidence was significantly lower in animals receiving indomethacin (56 per cent) compared with the control group (88 per cent) and with the meclofenamate group (90 per cent) (P less than 0.005). The corresponding figures for tumors in the small intestine were 31, 46, and 35 per cent, respectively. The tumors in indomethacin-treated animals did not differ in number, size, location, or spread from tumors of the other groups, suggesting that indomethacin might influence the carcinogenic process itself, rather than the natural course of the established disease. We conclude that indomethacin significantly reduces the incidence of large-bowel cancer in this animal model and that this observation may have some potential for future chemopreventive studies in human high-risk groups (e.g. ulcerative colitis, familial polyposis).

1,2-Dimethylhydrazine↗
PubMed1984

On the pathogenesis of pancreatic ascites.

The pancreatic ascites of 2 patients and the drainage fluid collected adjacent to the pancreas postoperatively of 1 of them were analyzed for protein composition and enzyme activity. We did not find a proteolytic activity, especially enzymatically active trypsin and chymotrypsin in these fluids. Immunoreactive (inactive) trypsin was, however, present in rather high concentrations. The drainage fluid changed from an inflammatory exudate to a fluid similar in composition to pancreatic juice later on. Our results indicate that pancreatic ascites consist of a combination of enzyme-rich pancreatic fluid and protein-rich exudate from the inflamed pancreas. No evidence of peritonitis or of proteolytic activity capable of inducing peritonitis was found.

Adult↗
PubMed1983

[The jejunal tube: a possibility for early postoperative enteral feeding].

Interest in enteral nutrition has recently been increasing. Enteral feeding is more physiological than parenteral nourishment; it is more effective, there are fewer complications, and it has the advantage of being cheaper. Enteral feeding is performed via nasogastric, nasoduodenal or transcutaneous catheter. The aim of the current study was to determine the usefulness of enteral feeding with the Intestofix-catheter in 20 cases undergoing surgery of the upper and lower gastrointestinal tract and to investigate its acceptability in clinical practise.

Digestive System Surgical Procedures↗
PubMed1982

[Thoraco-abdominal intestinal duplications. Case report].

The case of a 22-year-old patient with a thoracoabdominal duplication of the alimentary tract is described. The chest radiograph, with a large cyst in the posterior mediastinum and vertebral abnormalities and a barium swallow showing the abdominal part of the duplication, were diagnostic. At operation a malrotation of the midgut was found and the duplication was resected, leaving esophagus and small bowel intact. An explanation for association of the two malformations - vertebral abnormalities and malrotation - was sought in the literature, particularly that concerning embryogenesis. The following conclusions were reached: 1. Duplications of the alimentary tract are a heterogeneous group with three different embryological faults in development. 2. According to the so-called notochordal theory, vertebral abnormalities and malrotation of the midgut are usual and should be expected in thoracoabdominal duplications of the alimentary tract.

Adult↗
PubMed1982

[Transplantation of pancreas and kidney in diabetic nephropathy (author's transl)].

In juvenile diabetics with diabetic nephropathy transplantation of the pancreas at the time of renal transplantation is thought to improve the progression of diabetic complications. Between 1. 7. 1980 and 31. 12. 1981, nine kidney and pancreas transplants were performed for this reason. Five pancreas transplantations failed for non-immunological causes. Of four successful transplantations, two transplants were later rejected through non-reversible immunological cause. The function of both organs has remained normal in two patients after 18 and 9 months, respectively. These patients are normoglycaemic on a normal diet and, despite prednisone medication, do not require insulin administration.

Adult↗
PubMed1982

[Malignant tumors in bearers of kidney grafts in immunosuppressive therapy].

Out of 420 kidney transplant recipients at the University Hospital, Zurich, operated on between 1964 and 1978, 23 developed one or more malignant tumors. This corresponds to 5.8% of all patients. They included 8 cases of malignant lymphoma (non-Hodgkin), one of subacute myeloic leukemia, one of acute lymphatic leukemia, 6 skin cancers and 9 cancers of internal organs. Thirteen patients died, a figure corresponding to 8% of all deaths after kidney transplantation. Nine of the 10 patients with lymphoma and leukemia died, in 5 cases despite therapy. The response to therapy (radiotherapy and/or chemotherapy) was much poorer than in other patients with comparable tumors and in some patients completely absent. The only surviving patient (malignant lymphoma of the small bowel and the retroperitoneum) was treated by a combination of surgery, radiotherapy and chemotherapy and has had a symptom-free follow-up time of 3 1/2 years. The 6 skin cancers (4 of the spinocellular type) were excised. Recurrences were not noted. The visceral carcinomas (2 breast cancers, 1 carcinoma respectively of the pancreas, the rectum, the liver, the kidneys, the renal pelvis, and the urinary bladder, and one seminoma) were treated by generally accepted surgical principles as far as treatment of the patients was possible. The breast cancer and seminoma patients have survived thus far without recurrences or metastases.

Adult↗
PubMed1981

[Current state of surgery in the treatment of lung metastases].

64 resections and 51 instances of cryosurgical treatment in 102 patients with pulmonary metastases are reported. Under clearly established conditions, parenchyma-saving resection is often the only curative treatment for pulmonary metastases. Survival rates are 72% after one year and 35% after 5 years. Resection is also indicated after a short interval between the treatment of the primary tumor and onset of lung secondaries. Prognostic factors are histology of the primary tumor and progress of pulmonary metastases, measurable by tumor doubling time and the onset of new secondaries during a given short time interval. Cryosurgery for multiple metastases or local inoperable tumor has a one-year survival rate of 48% and a 5-year survival rate of 26%. While systemic therapy will change the role of surgery, its importance will increase as a factor in combined treatment modalities.

Adolescent↗