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Biomedical subjects

G V Gal'dinov

Publications and source records attributed to G V Gal'dinov.

11 recordsLinked to original sources

[Changes in neocortex function in the direct action of optical radiation].

Direct action of ultraviolet radiation with wavelength of 280, 310 and 365 nm increased the amplitude of neocortex EEG and enhanced the epileptiform activity in the penicillin--induced epileptic focus, whereas action of superthreshold radiation with wavelength of 580 and 630 nm decreased the EEG amplitude and suppressed the epileptiform activity. The mechanism of ultraviolet radiation effect on the neocortical electrical activity seems to be based on changes in permeability of neuronal membranes for Na and K ions and on following depolarization of the membranes, whereas the action of visible radiation leads to the heat injuring of neurons in the irradiated area which evokes irreversible suppression of their activity and reducing of their EEG amplitude.

Animals↗

[Suppression of epileptiform activity by micropolarizing brain structures].

Penicillin administration elicited epileptiform responses whereas micropolarization (MCP) affected the epileptogenic foci in cats with indwelled electrodes and chemotrodes. Three types of experimental epilepsy models were obtained: focal petit mal seizures, adversive, and grand mal seizures. The MCP of amygdala and caudate nucleus completely suppressed all three types of seizures whereas MCP of hippocampus enhanced the pathology. Two mechanisms of seizure suppression seem to exist: the inhibitory and the activating ones.

Amygdala↗

[Changes in the millivolt potential of brain structures during micropolarization influencing trace phenomena].

In chronic experiments on monkeys and cats, the effects of intracerebral micropolarization modulating memory processes, on the mV potential of cerebral structures, were studied. A connection was revealed between trace fixing and processes of systemic kindling on the one hand, and the following stabilizing of mV potential, on the other hand. The data obtained suggest that the distant changes of the mV potential reflect a general "tuning" of cerebral systems, are realized by means of specialized regulatory neuronal networks and connected with shifts in metabolic processes.

Animals↗

[Analysis of the interstructural relationships in the brain by the method of bioregulated micropolarization].

In chronic experiments on cats, automatic regulation of polarizing current, monitored with the EEG changes, aided to study elements of the cerebral selfregulating system. The method proved effective for influencing the functional state of the structures to be regulated which revealed itself in long-lasting shifts of theta-rhythm, in changes of excitability and readjustment of EPs. Three types of connections between the temporal cortex and a number of cerebral modulating structures: rigid (positive and negative) and flexible those, were revealed. The active inhibition was accelerated with the bioregulated micropolarization of temporal cortex and hypothalamus on extinction of alerting response.

Animals↗

Changes in neocortical function in response to the direct action of optical radiation.

The action of optical radiation on neocortical bioelectrical activity and on a penicillin-induced epileptic focus was investigated. The direct action of ultraviolet (UV) radiation with wavelengths 280, 310, and 365 nm was shown to increase the amplitude of the spontaneous EEG and to potentiate epileptiform activity, whereas the action of subthreshold radiation with wavelengths of 580 and 630 nm caused a reduction of EEG amplitude and inhibition of epileptiform activity. On the basis of the writers' own results and data in the literature it is postulated that the mechanism of action of UV radiation on neocortical electrical activity is based on changes in permeability of neuronal membranes to Na and K ions and subsequent membrane depolarization, whereas the action of visible radiation leads to thermal injury to the neurons in the irradiated zone, inducing irreversible suppression of their activity and a decrease in amplitude of the EEG.

Animals↗