Lethal orphenadrine intoxication: report of a case.
A case of lethal orphenadrine intoxication is reported. Included are the anatomical and toxicological findings. Most conspicuous histologically was the centrilobular necrosis of the liver.
Adult↗
Biomedical subjects
G V Giusti
Publications and source records attributed to G V Giusti.
Decrease of serum alpha-tocopherol levels in rabbits after acute treatment with delta9-tetrahydrocannabinol.
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Animals↗
Lethal nitrazepam intoxications, report of two cases.
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Adult↗
Determination of sub-microgram levels of alpha-tocopherol in serum by gas-liquid chromatography with solid injection.
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Animals↗
Muscular dystrophy in adult mice chronically treated with delta9-THC at behavioural doses.
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Animals↗
Myeloid hyperplasia in growing rats after chronic treatment with delta 9-THC at behavioral doses.
Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis.
Animals↗
Muscular dystrophy in mice after chronic subcutaneous treatment with cannabinoids.
Swiss male albino mice were treated subcutaneously with the main cannabinoids (CBN, CBD, delta9-THC) at the dosage of 1 mg/kg per day for 30 days, and with the crude resin. At the end of the treatment, after supramaximal stimulation of the sciatic nerve, a significant decrease of both maximal twitch and tetanus tensions was observed in delta9-THC-treated animals; CBD and resin treatment produced some decrease in active tension, while CBN treatment induced an enhancement of the contractile strength. Histology showed lesions interpretable as due to muscular dystrophy. Analysis of protein and hydroxyproline muscular content showed a marked reduction in protein in all treated animals, with a corresponding high increase in hydroxyproline content.
Animals↗
A lethal complication to gastric lavage leading to malpractice suit: a case report.
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Asphyxia↗