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Biomedical subjects

G V Petrov

Publications and source records attributed to G V Petrov.

7 recordsLinked to original sources
PubMed1994

[Dopaminergic mechanisms of the oculomotor behavior of primates].

Behavioral changes and eye movements were studied through chronic low-dose MPTP exposure (ten intramuscular injections of 0.2 mg/kg per day) in four monkeys (Macaca rhesus). The monkeys developed the deficit of spontaneous saccades and decreased oculomotor range. The vertical component of saccades were hardly reduced. The examination of vestibuloocular reflex revealed no changes (r = approximately 1.0), but the fast phase of nystagmus was blocked.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed1992

[The effect of amiridin on the MPTP-induced Parkinson-like syndrome in monkeys].

Development of behavioral disturbances was investigated during N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration (0,2 mg/kg, i/m, at 48 h. intervals, total dose 11.2-13.2 mg/kg) in experiments on two monkeys Macaca rhesus. MPTP induced the complex of symptoms, which are typical for idiopathic Parkinson's disease. Administration of amiridine (0,25-0,4 mg/kg) to MPTP-treated monkeys caused gradual decline of Parkinson syndrome. Mechanisms of action of amiridine are discussed.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗