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Biomedical subjects

G V Rodoman

Publications and source records attributed to G V Rodoman.

34 records · Page 2Linked to original sources
PubMed1990

[Evaluation of the effectiveness of an antiseptic preparation "Apolam" for the treatment of surgeon's hands].

The authors discuss the efficacy of sterilizing the surgeon's hands with apolam, a new antiseptic. This antiseptic is a surfactant referred to quaternary ammonia salts. Studies carried out in 140 volunteers have demonstrated high quality of sterilization with this antiseptic and its high activity against pathogenic and opportunistic microflora. No allergic reactions or local irritation symptoms were recorded. Reliable sterilization of surgeon's hands is achieved by mere plunging and standard treatment of the hands in 0.5 percent apolam solution for 60 sec.

Anti-Infective Agents, Local↗
PubMed1989

[The role of ultrasonic diagnosis in selecting the surgical tactics in suppurative-inflammatory diseases of soft tissues].

Ultrasonography was conducted in 66 patients with postinjection infiltrations, abscesses, postoperative scar suppurations, mastitis and other inflammatory conditions. Ultrasonography detected abscesses at different sites in 32 patients. Accurate topical diagnosis and the assessment of the size of the cavity, the number of chambers and the state of the adjacent tissues determined the choice of surgical strategy for each individual case, a radical abscessectomy being preferred in most cases. Ultrasonographic diagnosis of soft-tissue phlegmons at different sites of the body also made possible an urgent choice of a radical surgical procedure.

Abscess↗
PubMed1989

[Rapid methods of detection of bacteria in the bile].

Rapid methods are described for assessing the bacterial contamination, using direct phase-contrast microscopy, triphenyltetrazolium chloride (TTC) test, and a standard loop 3 mm in diameter, or by the detection of the biliary 'active' leukocytes and the microflora sensitivity to antibacterial drugs with the use of the TTC test and turbidimetric technique. These methods permit getting an answer in 4-24 hrs, are simple, and do not require special bacteriologic equipment, this recommending them for routine clinical studies.

Bacteria↗
PubMedDate not supplied

[Concentration and properties of albumin in the serum and peritoneal exudate in patients with peritonitis].

A new fluorescent method was used to study albumin concentration and properties in blood serum and peritoneal exudate of patients with peritonitis of different origin excluding pancreatogenic one. Total albumin concentration (TA), effective albumin concentration (EA) dependent on both TA and properties of binding sites in albumin molecules, and their ratio EA/TA dependent only on the site properties were measured. Peritonitis led to significant decrease of TA, EA and their ratio EA/TA. Thus, leak of blood albumin was accompanied by some change of albumin binding site structure. As a rule, albumin of peritoneal exudate was changed in the same extent of blood albumin, i.e. the albumin transfer from blood to exudate keeps it's changed structure because the ratio EA/TA correlated well in serum and exudate (r = 0.75) while the ratio was very mach variable both in serum and exudate. The gradient TA exudate/TA serum was found as a linear function of the serum TA with personal correlation coefficients from 0.8 up to 1.0 in 12 of 16 patients studied. The linear equation coefficients reflected character of the peritonitis development in these patients.

Ascitic Fluid↗
PubMedDate not supplied

[Blood fatty acid transporters in acute pancreatitis].

A relationship between of acute pancreatitis severity and concentrations of blood transporters of nonesterified fatty acids (albumin) and esterified fatty acids (lipoproteins) was studied. In necrotizing pancreatitis, there was a positive correlation between decrease of albumin and lipoprotein concentrations in serum, but no correlation was in edematous pancreatitis. High levels of serum albumin (> 32 g/L) and lipoproteins (cholesterol + triglycerides, CH + TG, > 260 mg/dL) had good prognostic value in terms of favourable development of this disease, whereas lower concentrations indicated unfavourable prognosis. Both albumin and lipoproteins appeared in the peritoneal exsudate where they represented 73 and 53% of the serum concentrations, respectively. Albumin efflux from blood to the exsudate correlated with lipoprotein efflux (r = 0.7) in necrotizing pancreatitis. The latter suggests that proteins penetrated together the tissue barrier blood/peritoneal space. The less albumin and lipoprotein concentrations in serum, the more they are in the exsudate (r = -0.57 and -0.47, respectively); probably, their concentration decrease in blood is due to to their efflux into the exsudate.

Acute Disease↗
PubMedDate not supplied

[Informative value of the parameter "effective concentration of albumin" in diffuse peritonitis: data from a multi-center study].

The paper represents data on new potentialities in evaluating a severity of patients with total peritonitis (TP). They are based on the fluorescence analysis of the physical-and-chemical properties of blood albumin. The findings are a result of a multi-center research undertaken by clinics of Moscow and Moscow Region. The properties of albumin-molecule binding sites were investigated by the fluorescence test. The parameter, measured in the test, was named "effective albumin concentration". The study protocol comprised the data of clinical examinations, scales SAPS and MPI as well as laboratory findings and EAC. The subsequent analysis denoted that a combination of 2 parameters, i.e. EAC and serum urea concentration routinely measured, is highly informative in evaluating the TP severity and correlates well with the survival rate in the discussed pathology. The study results could be a basis for an early individual prognostication of TP course made on the 1st postoperative day.

Fluorescent Dyes↗
PubMedDate not supplied

[Albumin redistribution between blood and peritoneal exudate in abdominal diseases].

Albumin concentrations were measured in blood serum (As) and in peritoneal exudate (Ae) of patients with peritonitis and acute pancreatitis. As and Ae registration during several days revealed strong negative correlation between an index, Ae/As, and serum albumin As in 51% of the patients. The absolute value of the linear correlation coefficient, r, exceeds 0.7 in each of these patients. Moreover, pooled data in this group of patients showed that integral correlation coefficient was very high, r approximately equal to 0.94 at p < 0.01. In other words, the higher ratio Albumin in exudate/Albumin in serum, the lower albumin concentration is in serum. Other patients had either lesser coefficient of the negative correlation, between -0.3 and -0.7 (14% of all patients) or very low negative or even positive correlation of the index, Ae/As, and serum concentration As (35% of all patients). Probable albumin redistribution between blood, peritoneal exudate and tissue pool in relation to ratio exudate Albumin/serum Albumin is discussed.

Acute Disease↗
PubMedDate not supplied

[Serum albumin in systemic inflammatory reaction syndrome].

A group of patients with pyoinflammatory surgical disease, which showed a strong correlation between the serum concentration of albumin and the number of signs of a systemic inflammatory reaction (SIR), was examined. It was found that the more number of such signs the patient had, the less blood concentration of albumin was: the linear correlation coefficient averaged -0.78 (p < 0.01) in the group. In the natural development of the disease, the larger number of signs of SIR (negative changes) is followed by decreased albumin concentrations and their reduction (positive changes) leads to an increase and even complete restoration of albumin concentrations. With a fatal outcome, there is a much greater drop in the serum concentration of albumin, which is inconsistent with the magnitude of criteria of SIR. The possible reasons for a reduction in blood albumin concentration and for ineffective correction of hypoalbuminemia in sepsis are discussed.

Adult↗
PubMedDate not supplied

[A method of determining the sensitivity of urinary microflora to antibacterial drugs].

A method has been developed for speedy determination of urinary microflora sensitivity to antibacterial drugs, which differs from other existing techniques by its simplicity and rapid realization. It is based on the capacity of micro-organisms as an aggregate of particles with a refraction coefficient, different from that of the environment, to increase its optic density by multiplication in a liquid nutrient medium in conditions of unlimited nutrition and space. Thus, increased optic density of a urinary specimen with an added antibacterial agent during incubation in a thermostat would indicate an increased count of micro-organism in the medium, i.e. the lack of sensitivity to the antibiotic in question. Optic density being unchanged under such conditions is evidence of the death (lack of growth) of the micro-organism population and, hence, its sensitivity to the anti-bacterial drug being assessed. The ultimate results being obtainable within 2 to 6 hrs and little effort involved are the advantages of this method over conventional techniques of the determination of urinary flora sensitivity to antibacterial drugs that are in current clinical use. Besides, adequate antibacterial treatment can already be initiated within the first day of admission where this test is used.

Anti-Infective Agents, Urinary↗