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Biomedical subjects

G V Selitskiĭ

Publications and source records attributed to G V Selitskiĭ.

At least 19 recordsLinked to original sources
PubMed2002

[Personal peculiarities of epileptic patients with depersonalization in the interictal period].

Depersonalization states, expressed in interictal period, were analyzed in 23 patients. Depersonalization state occurs only in patients with partial complex seizures with epileptic focus in the temporal areas of the right hemisphere and in the mediobasal frontal areas of the left hemisphere. Also, compared to healthy subjects, schizoid personality features by MMPI and Rorshach psychological tests were found in these patients. The depersonalization states studied were defined as neurotic ones, because they manifested after psychotraumatic situation and did not recur after psychotherapy.

Depersonalization↗
PubMed2001

[Impairments of different kinds of memory in patients with ischemic stroke].

27 patients aged 47-64 years with left hemispheric ischemic stroke with similar cognitive and educational levels were examined. Pharmacotherapy of the stroke directed to improvement of both memory and thinking was taken into consideration. To evaluate both different kinds of memory and a degree of the cognitive functions' impairments in the patients with a local ischemic stroke in anterior, posterior and middle parts of the left hemisphere the following tests were used: evaluation of both the immediate memory of the digits and the short-term audio-verbal memory; short-term trials of the pathological action of interference; Benton test, Meily test; evaluation of the declarative, procedure, semantic, strategic, mediated, long-term kinds of memory. It is shown that remembering of the new information concerning verbal names, digits, was worse in mediobasal, frontal and temporal location of the stroke in the left hemisphere and depended on clinical manifestations of the disorders. The working semantic and strategic kinds of the memory were also damaged, while long-term memory (autobiographic, professional) was impaired in less degree.

Aged↗
PubMed1999

[Disorders of speech and imagery functioning in children with epilepsy in the right or left cerebral hemisphere as primary loci of lesions].

The paper presents the relationship between the disorders of speech and a drawing. 40 epileptic 5-12 year-old children as well as 9 healthy children (a control group) were examined. There were analysed the disorders of speech, alterations of drawing in children with epilepsy, mechanisms of participation of the right or the left hemisphere in forming of speech and descriptive activity on different stages of ontogenesis and its compensation in dependence on the severity of the disease. In younger preschool age disorders of a speech and deficiency in drawing were determined by the damages of the right hemisphere, while a role of the left hemisphere in such processes increased later.

Child↗
PubMed1999

[The influence of hypogeomagnetic field on bioelectric activity of the brain in epilepsy].

An influence of geomagnetic field (GMF) on bioelectric activity of the brain was studied in 20 epileptic patients by the use of "hat", which attenuated GMF. A short-term attenuated GMF increased a EEG synchronisation by alpha-rhythm, generalized slow-waves discharges. Some similarities and differences were found in attenuated GMF effects and in the results of hyperventilation trial. The main role in perception of attenuated GMF belongs to the parietal area of the right hemisphere.

Adult↗
PubMed1998

[Mediated short-term influence of alternating magnetic field on the epileptic brain].

The changes of bioelectric activity of the brain hemispheres were studied under the influence of an alternating magnetic field (AMF), directed on the hand of 20 epileptic patients and 18 healthy normals. Under AMF influence there was intensification of epileptic activity--elevation of the focal bioelectric characteristics and of the processes of generalization. It permitted to apply AMF for diagnosis of epileptic focus. Under AMF influence more stable changes in posterio-parietal areas of the right hemisphere occur. The authors came to the conclusion that AMF effects were mainly realized with participation of right hemisphere.

Adult↗
PubMed1997

[Prefrontal epilepsy].

Prefrontal epilepsy was considered as one variation of frontal-lobar epilepsy with prefrontal location of the focus. 14 verified cases were selected as the basis of the analysis of etiological factors, clinical peculiarities and possible pathogenetic mechanisms of epileptic fits in prefrontal epilepsy: generalized convulsive attacks, seizures of sudden fall, fits of stillness and pseudofits.

Adolescent↗
PubMed1996

[The action of a magnetic field on the bioelectrical activity of the brain in healthy subjects and epilepsy patients].

The influence of reduced geomagnetic field as well as alternative magnetic field action on the brain bioelectric activity was analysed in 18 healthy individuals and in 20 epileptic patients. The alteration of magnetic field elevated functional activity of the brain synchronizing structures and increased either epileptic activity or activation of epileptic focus. The data allow to conclude that the magnetic field effects are mediated by the deep sensory nerve-pathways. The role of the right hemisphere in magnetic field perception and participation of back temporal areas in these processes are considered.

Brain↗
PubMed1992

[The trigger role of the left cerebral hemisphere in generalizing epileptic activity].

Overall 593 epileptic patients with left hemispheral lateralization of the focus and 46 patients with primary generalized epilepsy were examined. EEG and computerized mapping of cortical biopotentials were used. It has been shown that in right-handed patients, the left hemisphere triggers epileptogenesis whatever the site of the source of epileptic activity. The mechanism by which epileptogenesis is triggered includes the posterotemporal and central cortical areas of the left hemisphere.

Adolescent↗
PubMed1991

[Bioelectric activity of the cerebral cortex in patients with secondary generalized form of epilepsy under hypnosis].

A study was made of brain bioelectric activity in patients with secondarily generalized epilepsy under hypnosis. The disease manifestations were dependent on whether the site of the focus was in the right or in the left hemisphere. Hypnotic trance changes the neurodynamics of the focus and the level of interhemispheric relations, which depends on the focus lateralization. The authors demonstrate possibilities of that state, both positive connected with the diagnosis and treatment and negative ones restricting the use of hypnotherapy in the presence on the EEG of frequent epileptic phenomena or their slight provocation by hyperventilation.

Action Potentials↗
PubMed1991

[Various bioelectric correlations in primary and secondary epileptic foci].

Analysis was made of the EEG material of 122 patients, compiled on the basis of indispensable presence of bioelectric phenomena of both primary and secondary epileptic foci. Use was made of computerized mapping of spatial synchronism of cortical biopotentials. The authors show the differences between the secondary focal activity and the primary one, describe interrelations between the primary and secondary foci as the secondary focus is being formed.

Action Potentials↗
PubMed1991

[Bioelectric phenomena of the mechanisms of generalization of the epileptic activity in patients with the right hemispheric foci].

Overall 308 epileptic patients with right hemispheric focus lateralization and secondary generalized seizures were examined. Use was made of the EEG and computerized mapping of spatial synchronism of cortical biopotentials. The author provides evidence for the role of the left hemisphere, namely of its posterofrontal and central areas, as a mechanism that triggers generalization and inhibition of epileptic activity.

Action Potentials↗
PubMed1991

[Study of the topographic organization of cortical electric activity during hypnotic analgesia].

Experiments on 10 right-handed subjects were carried out to study the topographic organization of cortical activation processes by means of toposcopy of synchronous electric activity in hypnotic analgesia. The authors demonstrate the priority role of the anterior cortical areas of the left hemisphere in analgesia effects, which is connected with their importance in data realization and formation of the motivation affective component of painful sensation. Experiments have shown different manifestations of the functioning of diffuse nonspecific and local specific activation processes maintaining sensory analysis of painful stimuli and their affective cognitive estimation in the systems responsible for individual tolerance to painful sensations and analgesia effects and demonstrated a possibility of observing at the level of objective electrophysiological parameters of the phenomenon of pain components dissociation as one of the mechanisms of hypnotic analgesia.

Action Potentials↗
PubMed1990

[Use of the indicators of spectral power of cortical biopotentials for evaluation of the processes of generalization of epileptic activity].

Spatial density of spectral power of bioelectric cortical activity was analyzed in patients with primary-generalized (PG) and secondary-generalized (SG) epilepsy within a range of 0.5-30 Hz divided by 22 narrow bands. The range 0.5-7.0 Hz was shown to play a special role in epileptic activity generalization. The PG forms and SG epilepsy with a focus in the left hemisphere are characterized by the predominance of spatial density of spectral power in some bands of the low-frequency range in the cortical structures of the left hemisphere. On the contrary, SG epilepsy with a focus in the right hemisphere is marked by the same features in the cortical structures of the right hemisphere.

Action Potentials↗
PubMed1990

[The differential-diagnostic role of low-frequency spectral characteristics of the bioelectric activity of the brain in epilepsy].

As many as 110 patients with primary-generalized (PG) and secondary-generalized (SG) attacks were examined by means of computer mapping of spectral power of cortical biopotentials within a range of 0.5-30 Hz divided by 22 frequency bands. As shown by differential diagnosis, the PG forms of epilepsy and SG epilepsy with focus localization in different hemispheres turned out dissimilar. The difference lay in cortical topography of an increase of spectral power in certain bands of the low-frequency range 0.5-7.25 Hz. The left hemisphere was noted to play the key role (in the right-handed) in the "trigger" of the processes of epileptic activity generalization.

Action Potentials↗
PubMed1990

[Relation between the functional state of cerebral hemispheres and the location and dynamics of the epileptic process].

Computer mapping of spatial synchronism of cortical potentials led away from 48 points was performed in 110 right-handed patients with primary- and secondary-generalized fits. The clinico-electrophysiological analysis was employed to demonstrate a special role played by the left hemisphere in the processes of epileptic activity generalization in different disease patterns and characteristic features of diagnosing the generalized patterns of epilepsy and determination of the focus of localization. The data obtained can be used for disease prediction and estimation of the treatment efficacy.

Action Potentials↗
PubMed1986

[Effect of neuroleptics on the epileptic process].

Using the parameters of the special synchronization of cortical biopotentials, the authors studied changes in the function of the cerebral cortex in patients with the generalized form of epilepsy with a further progression of the disease and under the effect of the typical neuroleptic haloperidol and atypical neuroleptic clozapine. These drugs have been found to act differently on the epileptic process and on the effects of the hyperventilation test, which appears to be due to their differing ability to block receptors of the nigrostriatal and mesolimbic dopaminergic systems. The data have shown that haloperidol increases the risk of the development of epileptic attacks while clozapine reduces epileptic manifestations.

Anticonvulsants↗
PubMedDate not supplied

[Neurobiological problems of brain ischemia and post stroke epilepsy].

A review. Current literature data concerning pathophysiological mechanisms of cerebral ischemia and poststroke epilepsy are presented. Results of investigations of structural-functional changes in activity of inhibitory inter neurons, mechanisms of brain plasticity, and main components of neuroprotection in ischemia are also discussed. The presented data confirm the current concept of apoptosis and necrosis as a consequence of injuring action of ischemia, the role of excitotoxicity in pathogenesis of ischemia and poststroke epilepsy, and different kinds of plasticity in recovery of brain functions.

Animals↗