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G V Shestova

Publications and source records attributed to G V Shestova.

2 recordsLinked to original sources
PubMedDate not supplied

[Changes in the lesser circulation as affected by armin].

Experiments on narcotized cats have shown that intravenous administration of armine in DL50 (0.2 mg/kg) decreases the pulmonary blood flow by 52%. The reduction of the pulmonary blood flow is accompanied by a drop of pressure in the femoral artery, development of bronchoconstriction, bradycardia and arterial hypoxemia. The pressure in the lung artery remains rather high. At the beginning of intoxication the decrease of the pulmonary blood flow correlates with bronchoconstriction in a greater degree than with other indicators and as the pathological process deepens, the reduction of the pulmonary blood flow gets closely connected with bradycardia.

Animals↗
PubMedDate not supplied

[An experimental model of benzodiazepine intoxication].

It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.

Animals↗