Biomedical subjects
Publications and source records attributed to G V Vereshchagina.
Disordered thyroid status was detected in patients with various clinical and morphological forms of leukemia and with hypoplastic anemia. These disorders present as low triiodothyronine blood concentration and a deficit of this hormone in the body. A certain correlation has been detected between the degree of the thyroid status disorders and the leukemic process malignancy.
Thyroid status was evaluated in 265 patients with gastric pathology. The degree of tissue triiodothyronine (T3) deficiency was assessed versus stage and histologic pattern of tumor. Also, it was measured before and after surgery. No correlation was found in gastric cancer patients between T3 concentration, degree of blood--T3 level decrease and tissue T3 deficiency, on the one hand, and stage and histologic pattern of tumor, radical surgery and postoperative treatment, on the other. Said T3 parameters differed significantly in cases of chronic gastritis, gastric ulcer and polyps.
Investigations carried out in various transplantable tumours (Lewis carcinoma, carcinoma-37, melanoma B-16 in mice and sarcoma-45 in rats) did not show 125J-triiodothyronine accumulation by the tumour.
A quantitative assessment of T3 pool was performed in patients with malignant tumors of the esophagus, stomach, pancreatic head, rectum and colon as well as in patients with chronic gastritis, peptic ulcer and benign stomach tumors. A high T3 pool deficiency was noted in patients with malignant GIT tumors. It was assumed that such a deficiency was indicative of profound disorder of hormone supply of tissues which could be regarded as an endogenous factor of predisposition to the development of malignant neoplasms.
The leading role of the endocellular ways in the T3 formation among the thyroid hormones was revealed. Therefore new approaches to the evaluation of thyroid function disorder are required. On the basis of the radioimmunoassay the authors have devised a new method of the determination of quantitative deficiency of the T3 pool in the body. The author present the first results of its use in clinical practice for the evaluation of the severity of hypothyroid conditions and control over the efficacy of hormonal substitution therapy.
A comparative analysis of triiodothyronine (T3) and thyroxine (T4) distribution in organs and tissues of tumour-bearing and intact mice conducted wih 125J labelled T3 and T4 has shown considerable differences in the accumulation character of these hormones in mice with Lewis carcinoma and in intact animals in the liver, kidneys, lungs, adrenal glands, lymphatic nodes. Low T3 and T4 concentration in the blood of tumour-bearing mice was observed during the whole period of study.
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Somatotropin levels were compared in 337 cancer patients and controls, using radioimmunological methods. Lung and gastric cancer patients revealed relatively greater variations in its basal levels. This proved to be a paradoxical reaction to operative stress. The said reaction is attributed to disturbances which develop in the somatotropin self-regulation system of cancer patients.
Tissue triiodothyronine concentrations in patients with the "syndrome of low blood--triiodothyronine level" and controls were compared. The former group included 20 patients with chronic nontumor pathology and 30 lung cancer patients. 28 patients with clinically apparent hypothyrosis and 155 healthy subjects with normal thyroid function were in control. Tissues of lung cancer patients were shown to be extremely deficient in triiodothyronine. The importance of this phenomenon is discussed with relation to the role of this hormone in normal function of human body.
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Radiobiochemical test-sets in blood sera of 248 human subjects were used to assess total thyroxine, triiodothyronin, the coefficient of thyroxine activity, triiodothyronin binding ability of blood serum and the activity of the hypophyseal thyreotropic hormone. One hundred and sixteen human subjects showed malignant tumors located in the lung--54, in the stomach--47, in the breast --15.' Control groups comprised 81 practically sound individuals, 23 persons with benign tumors and 28--with chronic nontumor lesions of the stomach. An analysis of the data obtained has evidenced that in patients with malignancies the thyroid hypofunctioning is developing, which is manifested in the lowered level of a physiologically active hormone--triiodothyronin in the peripheral blood. In the presence of a malignancy in the organism the correlations between the hypophysis and thyroid are impaired that seems to be one of the indirect signs of a malignant affection.
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Using radiobiochemical methods "in vitro" by means of determining hormone production in blood serum, the authors studied the functional state of the hypophysis, adrenal glands, the pancreas and thyroid in 51 patients with lung cancer: stage I--in 8 patients, II--in 7, III--in 23 and IV--in 13. Histological structure: adenocarcinoma--in 9, epidermoid cancer--in 29, undifferentiated cancer--in 5. The analysis indicated that the hormonal disbalance in the organism of lung cancer patients is not evidenced by secondary clinical manifestations of the disease (atelectasis, suppuration, etc), there being a number of general regularities in the response of the hypophysis, adrenal glands, the pancreas and thyroid depending on the stage. This dependence shows a sinusoidal pattern maximum pronounced in stage I. Some common regularities in the endocrinous response of the hypophysis and adrenal glands are observed in different histostructure of the tumor, the response increasing in the following sequence: adenocarcinoma, epidermoid, undifferentiated cancer.
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