Biomedical subjects

G Váczi

Publications and source records attributed to G Váczi.

6 recordsLinked to original sources

PubMed1997

Comparison of results of different types of knee arthroplasties.

We summarise our experience gained with knee arthroplasties over 18 years. Between 1976 and 1994 1103 knee arthroplasties (1044 primary cases, 59 revisions) were performed at the Orthopaedic Department of the National Institute of Rheumatology and Physiotherapy in Budapest, Hungary. The diagnoses were osteoarthritis (OA) in 50.9%, rheumatoid arthritis (RA) in 40.7% and other causes in 8.4%. The average age of the patients at the time of the operation was 57.6 years (range 14-81 years). The types of primary implant were as follows: 60 constrained (hinge) prostheses, 876 unconstrained (sledge) prostheses, 108 semiconstrained (total condylar) prostheses. The mean follow-up period was 11.4 years for the hinge-type prostheses, 10.3 years for the unconstrained prostheses and 1.6 years for the semiconstrained prostheses. Reviewing the 59 revision cases, we conclude that complications with the constrained prostheses reached 17.8% and, most presented within the 1st year. Because of this high complication rate, the use of hinge prostheses has been reduced in this department to only selected cases. After sledge prosthesis implantation most of the complications (overall 5.3%) appeared after 1 year in aseptic circumstances. Given the short follow-up period of the semi-constrained total condylar knee replacement, apart from one infection in a patient with rheumatoid arthritis no other complication has been recorded. Summarising these data, it can be concluded that on average the knee function, using a standardised scoring system, improved from 38% to over 80% by introducing the semiconstrained total condylar knee prosthesis.

Adolescent↗

PubMed1993

[Knee arthroplasty with total condylar endoprosthesis].

Authors report on experiences gained with the Total Condylar knee prosthesis, representing the third generation in the development of the knee endoprosthesis. Based on results of 17 operations it is stressed that after the implantation in the severely degenerated or destroyed knee joint they succeeded to reach a significant decrease of pain and increase of the range of movement. After the implantation of the prosthesis adequate stability can be gained in knee joints without cruciate ligaments.

Adult↗

PubMed1993

[Low contact stress knee prosthesis system. Results and complications].

This paper reports on the global results of the low contact stress knee prosthesis system with mobile weight bearing surfaces. The follow-up result of 918 cemented and 963 cementless knee prostheses was in more than 90 per cent excellent and good 2-8 years after the operation. The ratio of complications connected with the construction decreased to 2.8 per cent in cementless prostheses. In the cemented series less variations of size were available and the problems with the tibial component were under 2, the complications with the patella remained under 1 per cent. The more than 12 years clinical use of the mobile weight bearing knee prosthesis system proved the success of the solution concerning the basic construction.

Aged↗

PubMed1991

[The effect of early surgical reposition of congenital hip dislocation and functional postoperative treatment on the development of the acetabulum].

Authors performed early operative reduction from anterior exposure after unsuccessful conservative treatment on 30 hips of 29 patients in 1981 through 1983. The age of the patients was 6-18 months at the time of the operation. After the excision of the obstacle of the reduction with preservation of the limbus the capsule was closed tight so that it could prevent redislocation. This way it became possible to make functional after treatment without plaster fixation and using Pavlik's harness and abduction splint. It was found that the postoperative development of the acetabulum was accelerated and the development of the acetabular roof reached in average during one year the healthy one and the articular movements were free. The development of the joint was the quicker the younger the age was in which the operation was performed.

Acetabulum↗

PubMed1984

Changes in serum cyclic nucleotide concentration during open-heart surgery.

Changes in serum cyclic AMP and GMP concentrations were studied in 14 patients undergoing open-heart surgery with cold cardioplegia. Blood samples were taken on total bypass from the radial artery and from the coronary sinus before aortic cross-clamping and 1 and 9 min after declamping. The samples were analyzed for cyclic nucleotides. The cAMP levels showed no pronounced change in the arterial samples, but were significantly increased in the coronary sinus samples after declamping of the aorta. The cGMP values showed the same trend of change in the arterial and the coronary sinus samples, viz. significant fall after aortic release, and after 9 min an increase. The cAMP/cGMP ratio after clamp removal showed pronounced increase in the first minute and some reduction at 9 min. All the changes were statistically significant. Beating recommenced spontaneously in seven hearts. The cAMP levels were lower in this group than in the patients without spontaneous recovery. The outset cGMP levels and the cAMP/cGMP ratio were higher in the latter group. Absence of increase in the cGMP level may be due to effectiveness of cardioplegia in reducing the energy requirements of the ischemic myocardium. The study indicates that hearts without spontaneous recovery of beating react more sensitively to hypoxia and have to use up more of their energy resources for restoration of function.

Adult↗

PubMed1977

Expression of the human cytomegalovirus genome in mouse cells and in human-mouse heterokaryons.

Mouse cells with an established human cytomegalovirus (HCMV) infection were fused with susceptible human embryonic fibroblast cells. CMV-specific early antigens could be demonstrated in the cytoplasm and cell-membrane of the heterokaryons. Treatment with 5-iodo-2'-deoxyuridine (IUdR) of the heterokaryons or of the latently infected mouse cells, prior to their fusion with human cells, could induce the appearance of immunoflourescent elements, characterised as late antigens, and of infectious virus. Our data show that the mouse cells, in the latent stage of infection, contain the whole virus genome and that the replication of the virus is controlled by a genetic mechanism of the host cells both in virus-harbouring mouse cells and in heterokaryons.

Animals↗