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Biomedical subjects

G Vŭrbanov

Publications and source records attributed to G Vŭrbanov.

9 recordsLinked to original sources
PubMed1989

[Clinico-laboratory characteristics of the cholestatic form of acute alcoholic hepatitis].

Altogether 108 patients with acute alcoholic hepatitis (AAH) were examined. Of these, 14 patients (13%) presented with the cholestatic pattern of AAH, 45 with extrahepatic cholestasis, and 45 were healthy. As compared with the total patients' group with AAH, the patients with the cholestatic form consumed alcohol in greater amounts. Due to intensive jaundice, 50% of the patients were admitted by error to the infectious clinic and 32% to the surgical one. The disease runs a comparatively grave course, the general conditions gets deteriorated, the body temperature rises, the patient senses pains in the right hypochondrium, skin pruritus is lacking. As compared with other patterns of cholestasis, cholestatic AAH is characterized by a higher thymol test, higher levels of cholesterol, low density lipoproteins, activation of gamma-glutamyl transpeptidase and aspartate aminotransferase and by a lower level of leukocytes, bilirubin, free fatty acids and alkaline phosphatase. Verification of the diagnosis demands the use of certain up-to-date instrumental methods. To identify the cause of cholestasis, great diagnostic significance is attached to echography.

Acute Disease↗
PubMed1989

[The clinico-laboratory characteristics of the cholestatic form of acute alcoholic hepatitis].

The study includes 108 patients with acute alcohol hepatitis, 45 patients with cholestasis and 124 healthy controls. In 14 patients (13%) cholestatic acute alcohol hepatitis was found. The patients with cholestatic acute alcohol hepatitis consumed considerably more alcohol than the other patients with acute alcohol hepatitis. The intensive jaundice led half of the patients with cholestatic acute alcohol hepatitis to the infectious diseases clinic and 32% of them to the surgical clinic. The course of the disease was heavy, with disturbed general condition, high temperature, pain in the right subcostal region but without itching. The patients showed higher levels of timol test, cholesterol, LDL-cholesterol, coefficient LDL/HDL-cholesterol, beta-lipoproteins, total lipids, gamma-GTP, ASAT and lower levels of leucocytes, bilirubin, SMC, alkaline phosphatase and LAP than the other patients with cholestasis. The patients with cholestatic acute alcohol hepatitis showed a higher level of total lipids and gamma-GTP than the other patients examined. The confirmation of the diagnosis implies the application of contemporary instrumental and invasive methods. The ultrasound examination is of special importance.

Acute Disease↗
PubMed1988

[Changes in the levels of serum lipids and lipoprotein fractions of patients with acute alcoholic hepatitis].

Some serum lipid and lipoprotein fractions were investigated in 58 patients with acute alcoholic hepatitis and in 20 clinically healthy subjects. A significantly higher level of cholesterol, total lipids, triglycerides, LDL-cholesterol, free cholesterol and a lower level of esterified cholesterol were detected in the patients with alcoholic hepatitis. The level of beta-lipoproteins was raised, a beta-lipoproteins/alpha-lipoproteins ratio rising significantly. In 71% of the patients the presence of LP-cholesterol as a symptom of evident or clinically latent cholestasis was revealed. The above changes were correlated, to a large extent, with the gravity of liver affection.

Acute Disease↗