Piribedil and platelet aggregation.
Piribedil at high concentrations inhibits in vitro ADP and thrombin aggregation effect on the rabbit PRP.
Biomedical subjects
Publications and source records attributed to G Vairo.
Piribedil at high concentrations inhibits in vitro ADP and thrombin aggregation effect on the rabbit PRP.
The synthesis of a series of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acids was accomplished by reacting some 2-aminopyridines with ethyl 2-chloroacetoacetate and then hydrolyzing the resulting ethyl carboxylates. Such new carboxylic acids were evaluated for antiinflammatory, analgesic, antipyretic, and ulcerogenic activities.
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In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were. Plasma renin concentration decreased after injection of Althesin and thiopental while increased after injection of ketamine.
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In their experimental researches the Authors showed that the well-known antihypertensive alpha-adrenergic stimulant drugs (clonidine, flutonidine and guanabenz) were able to antagonize at very high concentrations the platelet aggregation induced by ADP and by thrombin on rabbit PRP.
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During pentobarbital (25 mg/kg i.v. in 2 min), pentothal (15 mg/kg i.v. in 2 min) and ketamine (10 mg/kg i.v. in 2 min) narcosis, rabbits showed reduced platelet reactivity ot the direct aggregating effect of ADP (2 X 10(-5) M) and the indirect effect of thrombin (0.1 U/ml). Certain arousal drugs, specifically those of metabolic type such as SAMe (20 mg/kg i.v. in 2 min) and Thiola (166 mg/kg i.v. in 2 min) and of haemodynamic type such as nicergoline (6.66 mg/kg i.v. in 2 min) and hexobendine (5 mg/kg i.v. in 2 min) administered 31 min after narcosis induction, impede the depression brought on by narcosis on on platelet reactivity.
The Authors, thanks to experimental works, have established that piribedil at high concentrations inhibits ADP and thrombin aggregation effect on the rabbit PRP.
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