PubMed Health⌕ Search

Biomedical subjects

G Vargha

Publications and source records attributed to G Vargha.

At least 37 records · Page 2Linked to original sources
PubMed1978

Defective life cycle and low antibiotic production in submerged cultures of Streptomyces fradiae.

The life cycle of a Streptomyces fradiae strain producing high amounts of neomycin under industrial conditions has been investigated in liquid soybean medium where the production of antibiotic proved to be comparatively low. The changes occurring in the main macromolecular components and the enzyme activities of the mycelium during the life cycle and cytological observations proved that there was a block in the normal proecess of reproductive differentiation and a lack of exocellular alkaline phosphatase activity was found.

Alkaline Phosphatase↗
PubMed1978

[The change of pulmonary function and working capacity of patients with healed pulmonary tuberculosis in the course of 15 years (author's transl)].

Pulmonary function (VC, FEV1, RV) and physical ability with the same methods and even apparature were assessed in patients with pulmonary tuberculosis dismissed in 1958/59 as cured or markedly improved. The values of pulmonary function gained at dismission and 15 years later were compared with the trend of the data on physical ability and disablement in the course of the years. In patients invalidated from this disease a 3 times greater reduction of VC, a 9 times higher decrease of FEV1 and nearly a 2 times greater increase of RV was found than in patients with previous tuberculosis but still on the job.

Follow-Up Studies↗
PubMed1977

[Urographic evaluation of Vx2 kidney carcinoma and control implantation in rabbits].

The development of Vx2 carcinoma induced in the kidney of rabbits was followed by urography. First the X-ray anatomy of the renal pelvis in the rabbit is described, pointing out the differences against the human pattern. Urography is easy to carry out and to evaluate, and it revealed some sign of the turnover in 75,6% of the cases in the third week and in 100% after 21 days. The radiological symptoms are described and classified. These symptoms are not specific but call attention to the progress of carcinoma.

Animals↗
PubMed1976

[Experimental methods of creating V X 2 bone tumour in rabbits (author's transl)].

V X 2-carcinomas were induced in rabbit femurs by various methods. Inoculation near the periosteum after injury of the condylus medialis femoris was considered most successful. Results of 124 inoculations and 10 controls are demonstrated by angiograms, pharmakoangiograms and histologic photographs. Injury of periosteum and bone favors the taking and spreading of malignant growth.

Angiography↗
PubMed1976

[Enzymologic investigations of Vx2-carcinoma transplanted into the stomach of rabbits (author's transl)].

Suspensions of V x2-carcinoma cells were inoculated into the stomach wall of rabbits. In 26 animals, changes of lactic acid hydrogenase (total activity and isoenzyme distribution) were followed from the transplantation day to complete development of a tumor. Findings were compared with mucosa specimen taken from different parts of the stomach. As compared with control animals (injection of physiological saline solution into the stomach wall), total enzyme activity was elevated and isoenzymes showed characteristic distribution in homogenisates from tumorous tissue. Mucosa covering the tumor did not reveal such alterations of enzyme activity. It can thus be concluded that V x2 carcinoma was limited to submucosal layers and did not invade the mucosa. This conclusion was confirmed by histologic examination.

Animals↗