[Nocardiosis in immunosuppressed patients].
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Biomedical subjects
Publications and source records attributed to G Verger.
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The case is presented of a patient who developed a disseminated infection caused by M. chelonei which arose from a fragment of intravascular polyethylene catheter that had been inserted six months earlier.
A 40-year-old man had had a chronic, slowly spreading inflammatory process in the skin over the right knee of ten years' duration. Culture of a biopsy specimen grew Alternaria sp. Antimycotic susceptibility testing with flucytosine, amphotericin B, and miconazole nitrate was performed. The Alternaria was highly sensitive to the last two drugs. Miconazole nitrate, 1.2 g daily intravenously for 31 days, did not induce a clinical response. The lesions were then infiltrated with 10 mg of miconazole nitrate in 10 mL of polyethoxylated castor oil (Cremophor EL) twice weekly, with clearing of the lesions during a several-month period.
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