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Biomedical subjects

G Vivoli

Publications and source records attributed to G Vivoli.

At least 37 records · Page 2Linked to original sources
PubMed1989

Cadmium in blood, urine and hair related to human hypertension.

A case-control study was performed to assess whether cadmium is related to hypertension in a non-occupationally exposed population. 63 male subjects affected by mild stable hypertension, pharmacologically untreated, were investigated together with 63 male normotensive controls individually matched for sex, age, body mass index, smoking habits and work activities. Cadmium in blood, zinc and copper in serum, the three elements in urine and hair, together with some biological parameters involved in pathogenesis of hypertension, were investigated. The mean Cd blood value in hypertensives (H) was 0.58 micrograms/L vs 0.44 micrograms/L in normotensives (N) (t = 2.03; p less than 0.05) with a greater difference in non-smokers (0.41 micrograms/L vs 0.25 micrograms/L) (t = 2.69, p less than 0.01). Furthermore, both systolic and diastolic blood pressure were significantly related to cadmium blood levels (r = 0.20 and 0.19 respectively, p less than 0.05). Smoking habit affected cadmium levels only in the blood, not in the other biological matrices examined. No significant difference of cadmium content in urine and hair was found between normotensives and hypertensives but Cd/Cu ratio in urine was significantly lowered in the second group.

Adult↗
PubMed1987

Zinc and copper levels in serum, urine, and hair of humans in relation to blood pressure.

Zinc and copper status was evaluated in 63 early hypertensives and compared with that of 63 normotensives matched for sex, age, smoking habits and body mass index. Zinc and copper in serum, urine and hair were measured, and the serum activity of two zinc-dependent enzymes (AP and LDH) were analysed. Mean urinary copper concentration in patients was 14.11 micrograms g-1 creatinine compared with 9.16 micrograms g-1 creatinine in normotensive subjects (paired "t" = 3.94, p less than 0.001). Serum AP and LDH were significantly decreased (16 and 36%, respectively) in the patients compared with controls, although almost all values fell within the normal range of activities. Systolic and diastolic pressures were significantly and positively correlated to urinary copper excretion. These correlations were still apparent after correcting blood pressure values for other urinary measurements. Blood pressure levels (both systolic and diastolic) were also negatively correlated with the two zinc-dependent enzymes.

Adult↗
PubMed1982

[Behavior during the work week of biological indicators of exposure to lead].

The AA. have studied the weekly changes of haematic and urinary parameters of lead occupational exposure. For this aim, they have collected in 14 ceramic workers 3 blood samples for day and all urine samples for day and all urine samples from monday to friday. The PbB and FEP levels did not show significant variations during working week. The measurement of ALA in single urines shows that this parameter is characterized by remarkable fluctuations within the same day in all subjects examined. The correction of values by density gave negative results while the correction by creatinine decreases the daily fluctuations but only in some cases. The execution of test in urine of 24 hours seems to give the most reliable correlation with lead exposure levels because of its relative constancy during week.

Adult↗
PubMedDate not supplied

Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension.

Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigated together with 31 normotensive controls individually matched for sex, age, and smoking habits. Zinc and copper in serum and urine wee measured, and serum activities of alkaline phosphatase (AP), lactic dehydrogenase (LDH), copper-zinc superoxide dismutase (Cu-Zn SOD), lysyl oxidase (LOX), and monoamine oxidase (MAO) were evaluated. No significant difference in serum and urine zinc and copper content as far as in serum activity of zinc (AP and LDH) or copper (Cu-Zn SOD, LOX, and MAO)-dependent enzymes was found between hypertensives and normotensives. Positive relationships were found in normotensives between serum and urine levels of zinc (r = 0.577; p = 0.001) and copper (r = 0.394; p = 0.028), and between serum copper and Cu-Zn SOD (r = 0.534; p = 0.002). In normotensives, diastolic blood pressure and serum zinc were positively related (r = 0.370; p = 0.041). In hypertensives, inverse correlations were observed between diastolic blood pressure and AP (r = -0.498; p = 0.004) and Cu-Zn SOD (r = 0.452; p = 0.011), and between systolic blood pressure and LOX (r = -0.385; p = 0.033). Diastolic blood pressure was related to LDH inversely in hypertensives (r = -0.357; p = 0.049) and positively in normotensives (r = 0.457; p = 0.010). In normotensives, diastolic blood pressure was inversely related with MAO (r = -0.360; p = 0.046). These findings support the hypothesis that an imbalance of zinc and copper status might be involved in human hypertension.

Alkaline Phosphatase↗
PubMedDate not supplied

The epidemiology of selenium and human cancer.

The relation between the trace element selenium and the etiology of cancer in humans remains elusive and intriguing, despite the number of epidemiologic studies published on the topic. We address some methodologic issues, such as misclassification of exposure, particularly to single selenium compounds, effect modification, confounding, and other sources of bias, which may explain the inconsistencies in the literature. We also review the results of cohort studies, which have yielded either inverse or null or direct associations between selenium exposure and subsequent cancer risk. To date, no beneficial effect on cancer incidence at major sites, including prostate cancer, has emerged from the Finnish program begun in 1984 to increase the average selenium intake in its population. Populations exposed to unusually high or low levels of environmental selenium might offer unique opportunities to investigate if selenium exposure is related to the etiology of human cancer.

Anticarcinogenic Agents↗
PubMedDate not supplied

Adverse health effects of selenium in humans.

Epidemiologic studies and case reports have shown that chronic exposure to selenium compounds is associated with several adverse health effects in humans. An early toxic effect of selenium is on endocrine function, particularly on the synthesis of thyroid hormones following dietary exposure of around 300 micrograms Se/d, and on the metabolism of growth hormone and insulin-like growth factor-1. Other adverse effects of selenium exposure can be the impairment of natural killer cells activity and at higher levels, hepatotoxicity and gastrointestinal disturbances. Dermatologic effects, such as nail and hair loss and dermatitis, occur after exposure to high levels of environmental selenium. Assessing the toxicity and morbidity after long-term exposure to environmental selenium is difficult: neurotoxicity, particularly the degeneration of motor neurons leading to increased risk of amyotrophic lateral sclerosis, might occur after chronic exposure to both organic and inorganic selenium compounds. The results of laboratory investigations and cohort studies suggest that selenium species exhibit a bivalent effect in cancer, either increasing or decreasing risk. Current environmental selenium exposure limits appear to be inadequate for averting adverse health effects.

Biomarkers↗
PubMedDate not supplied

[Environmental concentrations of nitrous oxide and isoflurane in the operating theatre].

An environmental survey was carried out in the operating theatres of an Emilian hospital (North Italy) to ascertain: if concentrations of nitrous oxide (N2O) and isoflurane were within prescribed limits; if anesthetic pollution decreases when it is periodically controlled; if the degree of pollution from isoflurane can be predicted from N2O measurements. Three controls of anesthetic pollution were carried out at six month intervals using a photoacoustic spectrometry analyser. Mean concentrations of N2O were lower than the limits prescribed for renovated (50 ppm) or not refurbished (100 ppm) operating theatres in 58% of the surgical sessions examined. Mean concentrations of isoflurane were lower than the values proposed for halogenated anesthetics, used together with N2O (0.5 ppm) or alone (2 ppm) in 39% of the cases. Anesthetic pollution decreased only after the second control. Mean concentrations of isoflurane and N2O were correlated with a very good degree of association (r = 0.77). The survey highlights that pollution needs to be controlled in operating room because anesthetic levels often exceed the prescribed limits. Awareness of the problem is important to improve environmental conditions. N2O measurement is indicative of pollution from isoflurane but halogenated anesthetic must also be determined for a thorough evaluation of anesthetic pollution.

Air Pollution, Indoor↗
PubMedDate not supplied

[Monitoring occupational exposure to volatile anaesthetics in the operating theatre: environmental and biological measurements].

Concentrations of nitrous oxide (N2O) and isoflurane were measured in environmental and urinary samples from subjects occupationally exposed to volatile anaesthetics in operating theatres in a hospital in northern Italy. The aim was to establish whether: an automatic analyzer (Brüel & Kjaer 1302 spectrometer) can be used for fixed position sampling ("anaesthetist zone" and "surgeon/instrument nurse zone"); periodic monitoring of anaesthetics will reduce exposure; exposure to N2O and isoflurane is within legal limits; exposure differs between anaesthetists and surgeons/instrument nurses. Exposure to anaesthetics was monitored twice at six-month intervals. In the first test time spent in the operating theatre was noted and exposure levels were measured automatically. In the second test levels were monitored with passive personal sampling devices. Environmental concentrations of N2O determined by the spectrometer were correlated to urinary levels. Urinary levels of N2O calculated from the regression line were the same as those obtained with the personal samplers. Environmental and urinary levels of N2O decreased significantly from the first to second test. In the second sampling 70% of subjects had levels of exposure to N2O and isoflurane within prescribed environmental limits (50 ppm for N2O and 0.5 ppm for isoflurane). At the first test anaesthetists had significantly higher levels of exposure to N2O than surgeons/instrument nurses. The survey demonstrated that: fixed position sampling data related to time spent in the operating theatre can be used to gauge individual exposure levels; exposure levels decrease after tests following implementation of preventive measures; monitoring needs to be repeated because exposure levels often exceed legal limits; occupational exposure decreases when pollution in the anaesthetic zone is reduced.

Anesthetics↗
PubMedDate not supplied

Biological response to noise and other physical stressors in places of entertainment.

The present study was designed in order to evaluate if the stressors produced in discotheques, and in particular high levels of noise, may lead to the impairment of some psychophysiological functions. The survey was carried out on 34 students who were exposed to noise in a discotheque (with levels ranging from 90 to 103 dBA) and to other environmental stressors (vibrations, psychedelic lights) for a period of five hours. The same subjects were examined on another day in the absence of relevant acoustical and visual stimulations. Biochemical (urinary catecholamines and cortisol) and cardiovascular (blood pressure and heart rate) indicators of stress were measured. Selected psychophysiological functions (reaction-time task and visual acuity) and some personality traits were also estimated. An increase in urinary excretion of epinephrine, norepinephrine, dopamine and cortisol was observed in most of the subjects during their presence in the discotheque in comparison to the control condition. A moderate variation was found with reference to cardiovascular parameters. No significant variation of reaction time was observed in performance tasks, while a significant impairment of visual stereoscopic perception was detected after exposure to stressors in the discotheque. The preliminary findings suggest that physical stressors, and, in particular, noise, may be related to a marked activation of the neuroendocrine system and impairment of some sensory functions.

Adult↗