Biomedical subjects

G Vlad

Publications and source records attributed to G Vlad.

8 recordsLinked to original sources

PubMed2006

Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells.

Immunoglobulin-like transcript (ILT)-3 is a transmembrane receptor, which belongs to the immunoglobulin superfamily. In previous studies, we showed that allospecific CD8+CD28- T suppressor cells (Ts) induce the expression of ILT3 in human endothelial cells (EC) rendering them tolerogenic. Using a polymerase chain reaction (PCR)-based approach, we now demonstrate by cell fractionation and sequencing studies that ILT3 precursor RNA is expressed and retained in nuclei of resting EC. Ts interaction with EC or exposure of EC to interleukin-10 (IL-10) and interferon alpha (IFN-alpha) triggers processing of ILT3 pre-mRNA. Western blot analysis showed that the expression of the mature ILT3 transcript is accompanied by production of ILT3 protein.

CD28 Antigens↗

PubMed1997

[The variations of intraocular pressure in postpseudophakic implant].

The study represents a statistical analysis effected at a group of hundred patients from a total number of three hundred and thirty-three patients operated at Ophthalmological Clinic of Military Hospital from Sibiu with pseudophakic implant. The crystalline lens were implanted in anterior chamber as well posterior chamber. In 89 per cent was not established an increase of ocular pressure. In 7 per cent it was a transitory hypertension and in four cases was persistent. The most frequent cases were produced through pupillary obstruction, uveal reactions, remainders of crystalline lens and chronic uveitis caused by the implant. The transitory hypertension recovered at specific medical treat, but in the cases with persistent hypertension was necessary another surgical act with iridectomy or removing of the implant.

Aged↗

PubMed1995