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Biomedical subjects

G W Allen

Publications and source records attributed to G W Allen.

At least 19 recordsLinked to original sources
PubMed1987

Fluid flow in the cochlear aqueduct and cochlea-hydrodynamic considerations in perilymph fistula, stapes gusher, and secondary endolymphatic hydrops.

There is convincing evidence that the cochlear aqueduct is normally patent in humans and is of relatively constant size. It probably plays an important role in the balance between the perilymphatic, endolymphatic, and cerebrospinal fluid pressures. The flow rate of liquids through tubes is a linear function of pressure, viscosity, and length of the tube but is a fourth degree power function of the radius of the lumen. For this reason, the radius is the most critical factor determining the flow rate. Small variations in size of the cochlear aqueduct can cause very large variations in flow rate through it.

Cochlea↗
PubMed1979

Human laryngeal reinnervation: the Northwestern experience.

Recent publications have reported impressive success with laryngeal reinnervation utilizing a nerve-muscle pedicle. This innovative surgical procedure is claimed to be useful for unilateral and bilateral vocal cord paralysis. Although the surgical results reported by Tucker have been good, they have lacked corroboration from other centers. We have performed six laryngeal reinnervation procedures at Northwestern University Medical School. Four patients presented with bilateral vocal cord paralysis and two patients with unilateral paralysis. All six operations were successful in restoring vocal cord function. The technique, problems, and results are discussed. Our experience supports the initial reports of success with this new operation.

Aged↗
PubMedDate not supplied

Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A).

Twenty-eight patients were anesthetized with etoxadrol as primary agent. The anesthesia produced was characterized by profound analgesia and amnesia, while pharyngeal and laryngeal reflexes, as well as swallowing and lid reflexes, remained active. Systolic, diastolic, and pulse pressure were slightly increased, with associated tachycardia and tachypnea. A dose of 0.75 mg/kg produced anesthesia for an average of 26 (14 to 53) minutes. Alternating nystagmus was present for several hours and associated with dreams and/or visions that were pleasing to most patients. Six patients, however, had unpleasant dreams for up to 24 hours. One patient given an excessive dose (4.65 mg/kg) was cataleptic, amnesic, and analgesic for 6 days. The occurrence of unpleasant dreams and aberrations in over 20% of the patients suggests that the drug probably has little usefulness in anesthesia. However, the extreme safety of the drug (an LD50 equal to some 20 to 40 times the ED50) and the prolonged analgesia justified clinical testing. There was no evidence of metabolic or systemic organ system change from any of the clinical laboratory studies.

Adult↗