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Biomedical subjects

G W Brobby

Publications and source records attributed to G W Brobby.

10 recordsLinked to original sources

Developing appropriate community-based postgraduate training in a developing country.

The School of Medical Sciences, KNUST, established in 1975, indicated its educational orientation to a community-based and community-oriented system using the problem-based learning approach. Falling victim to the phenomenon of brain-drain, the School developed a postgraduate medical curriculum which takes into account the needs and demands of national governments and communities for quality specialist care and equitable distribution of existing health facilities. There is an innovative community-based fourth year for obstetrics and gynaecology, ophthalmology, otorhinolaryngology, paediatrics, surgery and medicine. After attainment of the Part I Examination, residents are sent to Ulm, Maastricht, Britain and the United States for clinical attachments for a period of 3 to 6 months before returning to sit for their Final Part II for the Fellowship of the West African College of Surgeons or Physicians (FWACS, FWACP). By ensuring that the Final Examinations take place after the elective attachment, none of the new breed of specialists so far produced has been lost to the Western world. The strengths and weaknesses of the programme are discussed.

Journal Article↗

Pattern of connexin 26 (GJB2) mutations causing sensorineural hearing impairment in Ghana.

Mutations of the connexin 26 gene (GJB2) were studied in 365 apparently unrelated individuals with profound nonsyndromic, sensorineural hearing impairment from Ghana, West Africa. Among 121 mutated chromosomes found, 110 carried the previously described R143W mutation. A total of 6 novel mutations: L79P, V178A, R184Q, A197S, I203K, and L214P, were identified, whereby I203K was based on a dinucleotide exchange and R184Q appeared to be dominant. The GJB2 variants found in Ghana tend to comprise less nonsense and frameshift mutations and more mutations located in the C-terminal half of the molecule than the variants found in other parts of the world.

Adolescent↗

Two cases of otosclerosis in Kumasi, Ghana, case report.

The incidence of otosclerosis in relationship to race has been established in North America; however, there are no reliable data about its occurrence among negro Africans. Over a period of three years 650 consecutive cases of hearing loss excluding those with acute and chronic otitis media, Eustachian tube dysfunction, wax, foreign bodies, and traumatic perforations, were studied in Kumasi, Ghana. Only two cases of otosclerosis were detected. It is postulated that the rarity among people of the black race may be related to the flat occipital protuberance of the skull among African people.

Adult↗