Biomedical subjects
Publications and source records attributed to G W Cleasby.
A 13-year-old white male was found to have a melanoma of the iris. Three treatments with xenon arc photocoagulation resulted in regression of the lesion with development of an iris coloboma. There were no complications, and corrected visual acuity has remained at 20/15 after a 19-year follow-up.
Explore the source record for details and available documents.
A 66-year-old man had malignant melanoma of the choroid that enlarged during a two-year period while a retinal detachment developed. Treatment consisted of a cobalt 60 plaque placed to deliver a dose of 35,000 rads to the base and 9,000 rads to the apex of the tumor. Clinical response was excellent and complete regression occurred. The patient later died of an unrelated disease. Histopathologic study verified complete regression of the tumor.
Corneal alterations from hard contact lens wear can have significant effects on the results of intraocular lens (IOL) calculation and this should be kept in mind in those patients who are candidates for lens implantation. Seven patients were studied during and two weeks after hard contact lens wear, showing an average increase of +0.79 +/- 1.05 (P less than 0.05) in keratometry reading and an average decrease of -0.98 in emmetropic IOL calculations after discontinuing contact lens wear. Since the effect of hard contact lens wear on corneal curvature and resultant IOL calculations is variable and unpredictable, it is important that IOL calculations be made well after discontinuation of hard contact lens wear.
Eight family members had familial exudative vitreoretinopathy. They exhibited a variety of clinical stages of the disease process. Some clinical findings included retinal detachment, fibrovascular masses with dragged disc and macula, neovascular fronds and intraretinal deposits. The fundus and angiographic findings were found to be similar to those in cases reported previously. Electroretinograms were normal. Of particular interest in this pedigree was the sole clinical finding of isolated intraretinal deposits in four family members. This characteristic may represent a mild expression of the disease and warrant appropriate genetic counseling. Our study confirms the variable clinical expression of the disease.
Explore the source record for details and available documents.
Information on the fate of the fellow eye in patients who have suffered loss of central vision in the first eye due to exudative senile maculopathy suggests that there is a high incidence of later loss of vision in the second eye due to the same disease process. It has been speculated that prophylactic photocoagulation of the macula in the fellow eye might have a protective effect. This is a preliminary report of a series of patients in which argon laser photocoagulation of the second eye has been performed.
An endoscope with a 1.7-mm diameter shaft has unique properties of focus, magnification, and large field of view that make it useful for both orbital and intraocular surgery.
Explore the source record for details and available documents.
Two independent, double-masked, controlled studies were made to evaluate the efficacy of calcium dobesilate for the treatment of nonproliferative diabetic retinopathy. Forty-two patients underwent a six-month crossover evaluation while receiving calcium dobesilate (750 mg per day) and placebo in random order. Thirty-six patients received calcium dobesilate (1,000 mg per day) or placebo for one year. Evaluation by clinical examination, fluorescein angiography, angiography, and fundus photography failed to demonstrate any beneficial effect of calcium dobesilate.
Hypotony after intracapsular cataract extraction was prolonged in 3 eyes because cyclodialysis clefts were inadvertently formed. One eye became normotensive with the topical application of corticosteroid; 2 required surgical intervention.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A technique is presented for removal of subluxated or dislocated lenses (ectopia lentis), along with performance of vitrectomy. It is believed that this method permits avoidance or reduction of the hazards and complications of techniques used in the past.
Photographic documentation of enlargement of congenital hypertrophy of the retinal pigment epithelium is shown in a 42-year-old white woman. No other reports of enlargement have been made and previous articles have stated that these lesions do not grow.
In 20 patients idiopathic focal subretinal neovascularization was characterized by a solitary focus of subretinal neovascularization at or near the fovea, associated with serous or hemorrhagic detachment of the overlying and adjacent sensory retina, or both. Although the lesions resembled the neovascular membrane seen in the presumed ocular histoplasmosis syndrome, none of the other associated characteristic ophthalmoscopic findings, considered essential to make the latter diagnosis, were apparent. In this group of patients, the incidence of positive histoplasmin skin tests was no greater than in the general population. Of the 20 patients, two had bilateral disease. In no case were there any other lesions of any kind in the afflicted or the opposite eye. The disease is self-limited over a variable period of time, but may result in extensive scarring with loss of central vision.
A simplified method of performing peripheral visual field examination with the Krimsky Eyecup is described. This technique is compared with Goldman perimetry in a series of patients with a variety of ocular pathology. The peripheral visual fields obtained by these two methods compare closely.