Biomedical subjects
G W Falk
Publications and source records attributed to G W Falk.
Acute colonic pseudo-obstruction associated with interleukin-2 therapy.
In this case report, we present a patient with metastatic gastric carcinoma who developed massive colonic dilatation during treatment with recombinant interleukin-2. The spectrum of gastrointestinal symptomatology associated with interleukin-2 therapy is broad. However, colonic pseudo-obstruction, to our knowledge, has never before been reported. We review therapy for colonic pseudo-obstruction and a proposed mechanism of interleukin-2 toxicity. We report this case to heighten awareness of the potential for the development of this complication in patients undergoing interleukin-2 immunotherapy.
Primary biliary cirrhosis in a patient with multiple sclerosis.
A 47-yr-old patient with primary biliary cirrhosis and multiple sclerosis is reported. Although primary biliary cirrhosis has been associated with numerous other autoimmune disorders, it has not, to the authors' knowledge, previously been reported in association with multiple sclerosis.
Effect of ozone and nitrogen dioxide on the agglutination of rat alveolar macrophages by concanavalin A.
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Pancreatitis after sphincter of Oddi manometry.
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Omeprazole: a new drug for the treatment of acid-peptic diseases.
Omeprazole is the first of a new class of gastric antisecretory drugs, proton pump inhibitors. It inhibits the H+,K(+)-adenosinetriphosphatase enzyme of the gastric parietal cell, resulting in potent, long-lasting suppression of basal and stimulated acid secretion. The drug is currently approved for treatment of gastroesophageal reflux disease and Zollinger-Ellison syndrome. In clinical trials, treatment with omeprazole results in rapid healing of duodenal ulcers; it is also effective in treating gastric ulcer disease. It is uniformly well tolerated without significant adverse effects, although animal studies linked profound long-term suppression of gastric acid secretion with the development of gastric carcinoids. Potential future uses include the prophylaxis of ulceration secondary to stress or use of nonsteroidal anti-inflammatory drugs, and the prophylaxis of recurrent peptic ulcer disease.
Trends in noncardiac chest pain.
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