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Biomedical subjects

G W Lewis

Publications and source records attributed to G W Lewis.

13 recordsLinked to original sources
PubMed1989

Interpleural block.

Explore the source record for details and available documents.

Anesthetics, Local↗
PubMed1976

Diastolic retroperfusion of acutely ischemic myocardium.

The effectiveness of coronary venous retroperfusion treatment of an ischemic myocardial segment was assessed by measurements of regional and global myocardial function in 16 dogs. The left anterior descending coronary artery was acutely occluded for 75 minutes. After the first 30 minutes of occlusion, diastolic retroperfusion was instituted for 45 minutes by synchronized pumping of arterial blood from the brachial artery into the anterior interventricular coronary vein. Data collected in the preocclusion control period, during occlusion and the subsequent retroperfusion period included simultaneous measurement os ischemic and border zone myocardial forces, epicardial electrocardiographic S-T segments, intracoronary pressure, coronary blood flow and oxygen pressure (PO2) sampled distal to the site of occlusion. Retroperfusion resulted in significant improvement from the level of regional dysfunction observed after 30 minutes of occlusion: Ischemic zone myocardial force increased 106%, epicardial S-T elevation decreased 46%, normalized peripheral left anterior descending coronary arterial flow increased 50% and distal left anterior descending PO2 decreased 44%. These regional improvements were significant when compared with findings in an untreated series of 12 dogs with 75 minutes occlusion of the left anterior descending coronary artery. Diastolic-augmented coronary venous retroperfusion with arterial blood provided significant but not complete restoration of function in the ischemic segment. Therefore, in the earliest phase of acute myocardial infarction, retroperfusion might represent a useful temporary support to an otherwise inaccessible jeopardized zone of the heart. Regional retroperfusion may constitute an effective emergency procedure, particularly when the occlusive lesions are diffuse and other medical or surgical emergency procedures are inadvisable, unavailable or ineffective.

Animals↗
PubMed1968

Optimal antibiotic therapy in cholera.

Intravenous replacement of the diarrhoeal fluid and electrolyte losses to restore a physiological state of hydration is well established as the basis for successful management of cholera patients. The use of oral tetracycline as an adjunct in reducing the volume and duration of diarrhoea, as well as eradicating the vibrio from the gastrointestinal tract, has been proven beneficial. An optimal dose schedule has not been established previously, and clinical or bacteriological relapses have been generally reported. Chloramphenicol and sulfaguanidine have also been mentioned as adjuncts. The present report shows that 3 g or 4 g of tetracycline in one of 3 dose schedules were predictably efficacious. Chloramphenicol, while of benefit, was not as effective and sulfaguanidine was of little benefit compared with the tetracycline regimens.

Adolescent↗
PubMed1965

Clinical and physiological observations during an epidemic outbreak of non-vibrio cholera-like disease in Calcutta.

During March through June 1964, an epidemic of acute non-vibrio diarrhoeal disease, closely simulating cholera, occurred in Calcutta. To clarify the etiology and pathophysiology and improve the therapy of this illness, bacteriological and metabolic studies were performed on 145 consecutive hypotensive adult male patients admitted with acute diarrhoeal disease to the Calcutta Infectious Disease Hospital. Bacteriological and serological studies clearly demonstrated that the majority of patients with acute diarrhoeal disease admitted during this period of time were not suffering from V. cholerae infection; no known pathogen could be recovered from 86% of such patients. Biochemical studies indicated that, in contrast to the findings in cholera, factors other than saline depletion contributed to hypotension in many of the patients with non-vibrio diarrhoeal disease. Although the majority of the acute diarrhoeal patients responded well to the 2: 1 saline: lactate regimen which is consistently successful in treating adult cholera patients, six of the non-cholera patients required prolonged administration of vasopressor drugs as an adjunct to fluid and electrolyte repletion therapy.

Cholera↗