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Biomedical subjects

G W Molnar

Publications and source records attributed to G W Molnar.

At least 19 recordsLinked to original sources
PubMed1981

Thyrotropin-releasing hormone and the menopausal hot flash.

The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continuously on the recumbent subject during the 2-h test. None of the women reacted either subjectively or objectively to the placebo. TRH induced gastric pain in 1 post-menopausal subject. In another subject TRH elicited no response during the first test, but a week later in a second test it evoked transient nausea and a series of hot flashes with bursts of sweating. Published results of animal studies suggest that a higher dose of TRH would probably stimulate hot flash-like responses in more women.

Adult↗
PubMed1981

Menopausal hot flashes: their cycles and relation to air temperature.

The occurrence of hot flashes was investigated exhaustively in 1 woman. She recorded the clock time of each hot flash in a notebook for 100 days. Fluctuations were circadian and day to day with sawtoothed periodicity. The circadian peak was always between 18 and 21 hours. The circadian nadir and the mean daily rate varied directly with outdoor temperature. The occurrence of hot flashes was not related to internal body temperature, and hence not to environmental heating or cooling of the body. Therefore impulses from temperature receptors altered the rate of formation and release of a hypothetic central nervous system neurohumor that stimulated the hypothalamic heat loss center. This mechanism did not exhibit acclimatization to heat. Comparably thorough studies on more women are needed.

Body Temperature↗
PubMed1979

Investigation of hot flashes by ambulatory monitoring.

The unpredictability of hot flashes makes their investigation difficult. A method for continuous monitoring of subjective arousals and their objective correlates is here described and illustrated with results from one subject. Temperatures of special interest with respect to hot flashes--toe, cheek, vagina, and air--were recorded on a protable magnetic tape during routine living at home. The subject signaled the "on" and "off" of each perceived flash with a hand switch and also entered information in a notebook. She signaled 63 flashes on 5 days, during which the cheek and toe temperatures showed transient increments. Some of the flashes were labeled uncertain in the notebook. The subject also had 23 episodes of these temperature increments that she did not identify by signals as flashes. In these episodes, therefore, the mechanism of consciousness was not activated. Perceptions that coincided with transient temperature increments thus ranged as follows: subconscious, uncertain, definite but bearable, mildly distressful, and strongly distressful. Hence ambulatory monitoring can provide objective evidence of transient activation of the hypothalamic heat loss mechanism, whether perceived or not.

Body Temperature↗
PubMed1976

Freezing temperature of finger skin.

In 45 subjects, 154 frostnips of the finger were induced by cooling in air at -15 degrees C with various wind speeds. The mean supercooled skin temperature at which frostnip appeared was -9.4 degrees C. The mean skin temperature rise due to heat of fusion at ice crystallization was 5.3 degrees C. The skin temperature rose to what was termed the apparent freezing point. The relation of this point to the supercooled skin temperature was analyzed for the three wind speeds used. An apparent freezing point for a condition of no supercooling was calculated, estimating the highest temperature at which skin freezes at a given wind speed. The validity of the obtained differences in apparent freezing point was tested by an analysis of covariance. Although not statistically significant, the data suggest that the apparent freezing point with no supercooling decreases with increasing wind velocity. The highest calculated apparent freezing point at -15 degrees C and 6.8 m/s was 1.2 degrees C lower than the true freezing point for skin previously determined in brine, which is a statistically significant difference.

Adult↗
PubMed1975

Body temperatures during menopausal hot flashes.

Body temperatures during hot flashes were measured in a menopausal woman. Internal temperatures fell after each flash; lowest: rectal, 35.6 degrees C; vaginal, 35.6 degrees C; tympanic, 35.2 degrees C. Where sweating occurred, the skin temperature fell during the flash and rose after it. Finger and toe temperatures always showed a sharp rise at the onset of a flash with a slower fall after the flash. Only the cheeks showed additional temperature rises; maximum, 0.7 degrees C. The heart accelerated 13% at the onset of the flash but slowed immediately thereafter. The flash interval was sharply demarcated by undulations in the ECG baseline. There was never any premonitory sign of the imminence of a flash. A central excitatory state seemed to build up, perhaps by the accumulation of a chemical compound, but not of heat, which was explosively dischargedmthe thermal distress was probably evoked by vascular warming in the cheeks. Dabbing the malar prominences with cold water brought prompt relief.

Body Temperature↗
PubMedDate not supplied

Plasma catecholamine concentration during and after aorto-femoral bypass grafting.

Mean arterial plasma concentration of norepinephrine and epinephrine [NE + E], increased from 2.84 nM (post-induction) to 7.50 nM at the end of an approximately 4-hour operation for aortofemoral bypass grafting (plus unilateral lumbar sympathectomy) in 13 men. It increased to 18.25 nM during the first hour of recovery, and fell to 9.58 nM by the next morning. Thus during recovery, arterial [NE + E], by exceeding the minimum of 10.6 nM [NE] necessary for vasoconstriction, is a probable contributor to postoperative vasospasm as previously hypothesized.

Adult↗