Biomedical subjects

G W Plourde

Publications and source records attributed to G W Plourde.

2 recordsLinked to original sources

PubMed2001

Target-directed enediynes: designed estramycins.

The goal of selective targeting of enediyne cytotoxins has been investigated using estrogenic delivery vehicles. A series of estrogen-enediyne conjugates were assembled, and affinity for human estrogen receptor [hERalpha] was determined. The most promising candidate induced receptor degradation following Bergman cycloaromatization and caused inhibition of estrogen-induced transcription in T47-D human breast cancer cells.

Alkynes↗

PubMed2000

Understanding enediyne-protein interactions: diyl atom transfer results in generation of aminoacyl radicals.

[formula: see text] The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodatively stabilized radicals.

Alkenes↗