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Biomedical subjects

G Waterman

Publications and source records attributed to G Waterman.

4 recordsLinked to original sources

Malignant melanoma: management guidelines.

The incidence of primary melanoma of the skin, once rare, has been increasing rapidly over the past few decades. Although it accounts for only 3% of all primary cutaneous malignancies, melanomas are responsible for two thirds of skin cancer-related deaths. Fortunately, early detection and surgical removal have resulted in a concomitant improvement in overall survival. Ongoing clinical trials are addressing various therapeutic alternatives, as well as whether any treatment modality will significantly increase response rates and survival in patients with advanced disease. These prospects are discussed, and current prognostic factors and available therapies reviewed.

Aged

Pigmented skin lesions in the elderly: considerations in the differential diagnosis.

Malignant melanoma affects all age groups, but its highest age-specific incidence is in the elderly. Early diagnosis depends on the ability to identify potential precursor lesions and subtle changes in melanocytic nevi indicative of malignant degeneration. Familiarity with the clinical appearance of the common benign pigmented lesions is essential to minimize unnecessary biopsy procedures. Certain clues aid the differential diagnosis and enhance early recognition, which is presently the most effective means of reducing both the morbidity and mortality from this most ominous of skin cancers.

Adult

Herpes zoster infection with trigeminal and facial nerve involvement.

In most cases, herpes zoster (shingles) infections are benign and self-limited, requiring no treatment. However, if patients are elderly or immuno-compromised, they are at increased risk of complications such as visceral dissemination, cranial and nerve palsies, ophthalmic zoster, and postherpetic neuralgia. We present a case of herpes zoster infection complicated by both motor and sensory involvement in an elderly man.

Aged