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Biomedical subjects

G Watson

Publications and source records attributed to G Watson.

113 records · Page 7Linked to original sources
PubMed1970

The concentration of amino acids by yeast cells depleted of adenosine triphosphate.

1. The ATP content of preparations of a strain of Saccharomyces carlsbergensis was lowered below 0.3nmol/mg of yeast by starving the yeast cells in the presence of both antimycin and 5mm-deoxyglucose. 2. When the depleted cells were put at pH4.5 with glycine up to about 20nmol of the amino acid/mg of yeast was absorbed without being chemically modified. The mechanism did not depend on an exchange with endogenous amino acids. 3. The concentration of the absorbed glycine could apparently reach 100-200 times that outside the cells. 4. Replacement of the cellular K(+) by Na(+) almost stopped amino acid absorption in the presence of antimycin and deoxyglucose, but not in their absence. 5. It is suggested that, when energy metabolism itself had stopped, a purely physical process, namely the movements of H(+) and K(+) into and out of the yeast respectively, served to concentrate the amino acids in the cells. Both ionic species appear to be co-substrates of the system transporting amino acids.

Adenosine Triphosphate↗
PubMedDate not supplied

Monomorphic (basal cell) salivary adenoma of ovary: report of a case.

A pregnant 26-year-old woman presented with an asymptomatic 10-cm left ovarian mass diagnosed at 19 weeks gestation. On removal, the tumor was shown to be a cribriform variant of basal cell salivary adenoma with no other teratomatous or germ cell tumor elements present. The pregnancy continued uneventfully to term and the patient remains symptom-free 10 months after diagnosis. Tissues of salivary type are occasionally observed within mature cystic teratomas of the ovaries and are presumed to have given rise to the present lesion, which is thought to be the first reported case of a neoplasm of salivary type arising in the ovaries.

Adenoma↗
PubMedDate not supplied

Pathology of osseous and genitourinary lesions of Proteus syndrome.

A male patient followed from the age of 3 to 25 years was eventually diagnosed as having Proteus syndrome. He was born with linear epidermal nevi of the neck and forearm and presented with macrodactyly of the right hand and progressive hemihypertrophy of the right lower limb recurring after multiple reduction operations. The bone ends showed disorderly overgrowth of hyaline and fibrocartilage mixed with collagen and bone, and early differential diagnoses included Ollier's disease. The child also had vertebral anomalies, scoliosis, a bony protrusion of the cranial vertex, and strabismus. In the second decade he developed gyriform swelling of the soles, retinopathy, bilateral papillary cysts of the epididymis, and a giant cyst of the left kidney with complex glandular foci. At 22 years a 3-cm meningioma containing adipose tissue was resected, and at 24 years a 3-cm cellular nodule of the rete testis with hyperchromatic foci, probably an adenoma, was removed. The features of Proteus syndrome were those of hyperplasia and neoplasia of mostly mesodermal tissues. Unlike other reported cases, overgrowth of a finger recurred at 25 years.

Adult↗
PubMedDate not supplied

Computerized prompts for cancer screening in a community health center.

BACKGROUND: We describe the implementation and subsequent use of a computerized health maintenance tracking system in a large, urban, North Carolina community health center (Lincoln Community Health Center) as part of a larger study designed to increase rates of mammography, Papanicolaou tests, and smoking cessation in low-income African-Americans. METHODS: Clinicians from the Lincoln Community Health Center were involved in the design and implementation of the computer system. At each office visit, clinicians received a computerized encounter form indicating needed screening tests, counseling, and immunizations for each randomly selected study patient (n = 1318). RESULTS: Initial clinician compliance rates with filling out the form were 95 percent (mammography), 82 percent (Papanicolaou test), 77 percent (clinician breast examination), and 55 percent (smoking cessation). Cumulative compliance leveled off at 21 months to 65 percent, 57 percent, 53 percent, and 38 percent, respectively, despite multiple reminder strategies. When surveyed, most clinicians thought it was a good reminder system but said they did not always complete the form because of time demands. Costs of adapting and implementing the system were $23,332.08 ($17.70 per study). Per-patient costs would have been reduced further if more patients had been included in the project. CONCLUSIONS: State-of-the-art computer prompting systems can be useful in a community health center; however, even with prompting, clinicians still only addressed health maintenance with their patients about 50 percent of the time. Additional interventions will be needed, particularly in low-income populations, to meet the Healthy People 2000 goals in health promotion.

Adolescent↗