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Biomedical subjects

G Weingarten

Publications and source records attributed to G Weingarten.

7 recordsLinked to original sources
PubMed1998

Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.

Mechanism based inhibitors of HCMV protease have been designed based on the monocyclic beta-lactam nucleus, which have been shown to acylate the viral enzyme in a time dependent manner. SAR in a series of monocyclic beta-lactam N-ureas, has defined the size and relative stereochemistry of the C-3 substituent producing a low micromolar inhibitor 17b with good aqueous stability and selectivity over the mammalian serine proteases.

Drug Stability↗
PubMed1988

Type A personality components and the blood pressure response to dynamic exercise.

One hundred and eleven healthy male subjects underwent cycle ergometry testing and completed a Jenkins type A personality survey. The subjects were divided into three equal groups with respect to their distribution on the Jenkins scales. The groups were compared for heart rate (HR), systolic blood pressure (SBP), the ratio of SBP/HR, and VO2 max/kg during rest and at exercise. Repeated measures MANOVA indicated that high scoring type A had lower HR values during exercise with no differences in SBP. However, the SBP/HR ratio was higher in the high type A group. The same was true for the component of hard-driving and competitiveness. Those scoring highest in this component also had higher VO2 max/kg body weight. From the description it could be conjectured that those with higher scores on type A components push themselves harder and thus achieve improvement in fitness. No clear explanation exists for the relative differences in SBP response.

Adult↗
PubMed1985

A statistical reevaluation of the STAI anxiety questionnaire.

This study examined the capability and efficiency of two commonly used scales, the trait and trait and state inventories (Spielberger et al., 1970), to measure anxiety construct (N = 100). The probabilistic Rasch Model (Wright & Masters, 1982) was applied to athletes' responses to trait and state anxiety items before competition (stress). The analysis indicated that several items of both scales produce misfit responses, share identical locations on the continuum, and do not produce equal units of measurement. The findings question the generalizability of the research on anxiety. Recommendations for improving the anxiety tests are made.

Adult↗
PubMed1976

Choledochocele of the common bile duct.

The eighth report case of choledochocele is described. This lesion is a cyst communicating with the terminal portion of the common bile duct. It is characteristically lined with duodenal mucosa and is probably a form of duplication of the duodenum. The surgical treatment is marsupialization of the cyst to the interior of the duodenum.

Adult↗