[The current state of CNS prophylaxis with 198 gold colloid and 60 telecobalt in juvenile acute leukemias and non-Hodgkin's lymphomas].
Explore the source record for details and available documents.
Acute Disease↗
Biomedical subjects
G Weinmann
Publications and source records attributed to G Weinmann.
[Thrombolytic therapy in pediatrics].
Explore the source record for details and available documents.
Child↗
[Consumption coagulopathies in childhood. I. Physiopathology, diagnosis, therapy].
Explore the source record for details and available documents.
Adrenal Cortex Hormones↗
[Problems of consumption coagulopathy in congenital heart defects].
Explore the source record for details and available documents.
Aortic Valve Stenosis↗
[Studies on thrombocyte function in children with connatal heart failures].
Explore the source record for details and available documents.
Adolescent↗
[Catamnestic studies on premature infants treated with tetracycline with reference to growth disturbances and tooth changes].
Explore the source record for details and available documents.
Child↗
[Improved results in the treatment of acute myeloid leukemia - Results of study AML-BFM-93 in East Germany with comparisons to the preceding studies AML-I-82 and AML-II-87].
BACKGROUND: Three multicenter studies were conducted in East Germany on the treatment of acute myeloid leukaemia in children. The latest of the three studies (AML-BFM-93-OST) was part of the common German study AML-BFM-93. PATIENTS AND METHODS: The total number of registered patients was 262. The number and dosage of administered chemotherapeutic agents was elevated with each new study. RESULTS: Both the remission rate (85 %) and the likelihood of an event free survival (52 % after 5 years) could be improved significantly in study AML-BFM-93-OST. The results of the common German study AML-BFM-93 were identical to those of the East German part AML-BFM-93-OST. Compared with international studies it was one of the most successful treatment strategies in children with AML. Patients who showed toxic side effects to heart, liver, kidneys, skin or nervous system during the chemotherapy had a significantly lower risk of relapse, once they overcame the intensive therapy. During the five years of study AML-BFM-93-OST, treatment results could be improved despite an unchanged therapy strategy. This may partly be due to the modernisations and restorations that were carried out in many East German hospitals in this time. CONCLUSIONS: The therapy regimen of study AML-BFM-93 allowed a substantial improvement in the treatment of children with AML. Further intensification of chemotherapy should only be undertaken in accordance to the individual sensitivity of each patient.
Acute Disease↗
[Herpesvirus infections in children with acute lymphatic leukemia].
33 children with acute lymphatic leukemia and 33 healthy controls were longitudinally studied for herpesvirus infections. Active herpes simplex-virus, varicella-zoster virus and cytomegalovirus (CMV) infections were more frequent in patients than in controls. CMV and Epstein-Barr virus infections were often inapparent or associated with infections of the upper respiratory tract. Analysis of serological datas revealed a coincidence of active CVM infection and lethal course of the leukemia. This may be a result of the immunodeficiency in leukemia patients caused by disease and therapy. An additional influence of the immunosuppressive effect of active CMV infections on the course of the disease is discussed.
Adolescent↗