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Biomedical subjects

G Wieselmann

Publications and source records attributed to G Wieselmann.

21 records · Page 2Linked to original sources

[Nocturnal sleep studies of bruxism].

Polygraphic recordings during two nights sleep in 7 selected outpatients prior to and following treatment of bruxism were carried out using EMG-, EEG and EOG-recordings to evaluate the activities of the masseter muscle and the different sleep stages. The results thus obtained were compared to those of an age-matched control group. Following treatment with occlusal splints the recordings were repeated eleven weeks later. The length and the amount of grinding and pressing activities were correlated with the total night sleep as well as with the different sleep stages. The highest incidence of muscle activity was found in stage two and during awakening. Furthermore muscle activities were observed immediately before the beginning of REM-sleep and in particular during the change from REM- to NREM-sleep and in sleep stage one. After treatment with occlusal splints there was a decrease of total muscle activity, thus indicating efficiency of the treatment.

Adult↗

5-Hydroxy-indolacetic-acid (5-HIAA) serum levels in depressive patients and ECT.

In 31 drug and ECT naive melancholic patients, serum levels of the major metabolite of serotonin 5-hydroxy-indolacetic-acid (5-HIAA) were estimated in the first and third ECT of a course. Plasma samples were taken before ECT and 1, 60 and 120 min thereafter. The estimations were done by a new high performance liquid chromatography method (HPLC). After the seizure, a statistically significant decrease of 5-HIAA serum levels was observed over both ECTs. There was a significant increase in 5-HIAA serum levels from the first to the third ECT. ECT was found to influence serotonin turnover. It might be interpreted that ECT improves serotonergic responsiveness and neurotransmission. There was no significant correlation between 5-HIAA levels and gender, or age of the patients, or seizure duration. Furthermore, the severity of depression and treatment response did not correlate with certain 5-HIAA serum level patterns.

Adult↗