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Biomedical subjects

G Wind

Publications and source records attributed to G Wind.

7 recordsLinked to original sources

Study of upper extremity growth and development using human embryos and computer-reconstructed models.

This study investigated the apical ectodermal ridge and early vasculature of the human limb bud by use of histologic techniques and a new method of computer modeling. Fourteen human embryos were studied (more than 10,000 sections) microscopically and the embryonic limbs were reconstructed three-dimensionally by use of a serialized programming method. The apical ectodermal ridge consists of an extensive band of specialized cells, located over the rim of the limb surmounting a strip of rapidly-dividing mesenchymal cells. It is consistently supplied by a large vessel that shows extensive central branching.

Arm

Three-dimensional computer graphic modeling of ballistic injuries.

Multiple variables affect the tissue destruction caused by missiles, and the interaction of these variables is incompletely understood. The recently developed technology of computerized solid modeling now makes it possible to analyze these parameters in three dimensions. A technique for creating solid models of organic structures is described. The tissues within the boundaries thus defined are ascribed physical attributes by means of finite element analysis with data derived from empirical studies. An interactive user-friendly program is being developed combining this modeling with a probabilistic scheme (Monte Carlo simulation) to describe a variety of wounding scenarios. The data from these predictions will be compared with information from wound registries and the model refined until it can project consistently accurate patterns of injury.

Computer Graphics

Computer graphic modeling in surgery.

The application of computer-based solid modeling techniques to human anatomy shows great promise for enhancing surgical instruction and research. Such advances will directly benefit patient care. The increasing availability of powerful modeling programs for the microcomputer and the interactive peripheral technologies make the delivery of this new modality practical at the present time. We continue to refine our methodology for producing accurate and esthetic anatomic models and have developed a technique for three-dimensional "sculpting" of elongated structures. We continue to explore the possibility of using sectional scanning data to create anatomic images. Several applications have been described, ranging from surgical simulations to a ballistic injury model, in order to indicate the potential scope of this powerful technology.

Computer Graphics

Bright-light amaurosis fugax: an unusual symptom of retinal hypoperfusion corrected by external carotid revascularization.

The eye often serves as an important monitor of carotid artery disease by manifesting visual disturbances before cerebral events. The most typical ocular symptom complex is amaurosis fugax characterized by loss of vision in one eye that occurs suddenly and clears within seconds to minutes. This symptom is a hallmark of carotid artery disease and is usually caused by an embolic event. Although monocular visual disturbance on a hemodynamic basis is a more unusual manifestation of carotid artery disease, significant stenosis in combination with a low-flow state can cause transient, unilateral telescoping of vision. This report describes another visual disturbance associated with carotid artery disease in which unilateral visual loss occurred upon exposure to bright light. We term this syndrome bright-light amaurosis fugax and document successful treatment by external carotid artery revascularization in two patients.

Arteriosclerosis

Obstructive jaundice secondary to hepatoma. Case report and literature review.

A 67-year old male, who presented a clinical picture of obstructive jaundice with cholangitis, was found to have hepatoma tumor embolus blocking the common duct. The site of invasion was the right hepatic duct. There are 15 such cases reported in the literature. Hepatoma rarely presents with obstructive jaundice. A clinical picture of biliary colic or cholangitis is frequently misleading. Invasion of a hepatic duct large enough to allow formation of a tumor embolus implies tumor close to the bifurcation of right and left hepatic ducts and has precluded effective surgical treatment in all but one case.

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