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G Xing

Publications and source records attributed to G Xing.

41 records · Page 3Linked to original sources
PubMed1991

[Botanical survey and quality evaluation of Chinese drug shiwei (folium Pyrrosiae)].

This paper deals with a botanical survey and identification of the Chinese drug Shiwei (Folium Pyrrosiae) on the basis of three most widely used species included in the 1985 edition of Chinese Pharmacopoeia, six species used in some districts of China, and two adulterant species. Three active constituents in seven species of Folium Pyrrosiae (mangiferin, isomangiferin and chlorogenic acid) have been determined.

Antiviral Agents↗
PubMedDate not supplied

Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1.

The Wilms' tumor 1 (WT1) gene is a tumor suppressor gene that encodes a zinc-finger transcription factor. WT1 represses transcription of several growth factors and growth factor receptors. The N-myc proto-oncogene encodes a transcription factor which regulates cell growth and differentiation. N-myc is coexpressed with WT1 in the developing kidney and is overexpressed in many Wilms' tumors. Here, we show that the proto-oncogene N-myc promoter was down-regulated by WT1 in transient transfection assays. However, mutant WT1 (R394W) which has a mutation in the DNA binding domain could not repress the N-myc promoter. Electrophoretic mobility shift assays showed that the oligonucleotides containing the WT1 motifs could bind recombinant WT1 proteins. This suggests that the repression of the N-myc promoter is mediated through the WT1 binding sites. This finding may help to elucidate the relationship of WT1 and N-myc in tumorigenesis and renal development.

Binding Sites↗