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Biomedical subjects

G Y Guillet

Publications and source records attributed to G Y Guillet.

6 recordsLinked to original sources
PubMed1984

Bowenoid papulosis. Demonstration of human papillomavirus (HPV) with anti-HPV immune serum.

Two cases of bowenoid papulosis (BP) occurred. The presence of human papillomavirus was demonstrated in one patient. In the other patient, condyloma acuminatum developed after initial spontaneous improvement in his lesions. The discovery of a possible oncogenic virus in BP and the epidemiologic behavior of carcinoma in situ and multicentric carcinomas suggest the need for a very careful follow-up evaluation of such lesions. Bowenoid papulosis may be a chronic dysplasia with a variable long-term prognosis linked to a cocarcinogenic factor.

Adult↗
PubMed1983

The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern.

A monoclonal antikeratin antibody, designated AEl, was used to stain frozen sections of normal and abnormal human skin by the immunofluorescence and peroxidase-antiperoxidase techniques. In normal human epidermis and ichthyosis vulgaris, a nonproliferative epidermal disease, this antibody selectively stained epidermal basal cells. Very different staining patterns were observed in various other epidermal diseases. A suprabasal staining pattern was observed in psoriasis (16 cases), verruca (9), seborrheic keratosis (5), actinic keratosis (2), as well as the epidermis adjacent to certain epidermal neoplasms (4). Basal cell carcinoma (7) showed weak, homogeneous staining. In contrast, a disorganized pattern consisting of cells with various staining intensities was observed in Bowen's disease (2) and squamous cell carcinoma (4). Although the biochemical basis for these altered staining patterns remains to be elucidated, these results provide further evidence that epidermal keratin expression can be affected by various disease states. Moreover, our data suggest that a common alteration in keratin expression, as defined by the suprabasal AEl staining pattern, exists in psoriasis and a number of other benign hyperproliferative epidermal diseases.

Animals↗
PubMed1983

Pseudoscleroderma and phenylketonuria.

An infant girl with partial phenylketonuria developed pseudoscleroderma. After six years of follow up, both the neurologic and cutaneous conditions improved under a phenylalanine restricted diet. The probable roles of phenylalanine, tryptophan, tyrosine, and their metabolites may cause both conditions through possible transient hypersensitivity of cutaneous and muscular tissues.

Biopsy↗
PubMed1982

Cutaneous and mucosal warts. Clinical and histopathological criteria for classification.

The clinical and histopathological study of cutaneous and mucosal warts demonstrates divergences between clinical and histopathological diagnoses among the group of myrmecias, mosaics, acrodigitate, and common warts. There is correlations criteria (when considered separately), such as hyperkeratosis and absence of keratohyaline granules in flat warts, and in ano-genital vegetations. The existence of clinical and histological overlaps emphasizes that it is not clear whether these cases are rare clinical varieties caused by as yet unknown types of human papillomaviruses, or rather by differences in the degree of keratinization at different sites in the body.

Humans↗