PubMed Health⌕ Search

Biomedical subjects

G Yildiran

Publications and source records attributed to G Yildiran.

8 recordsLinked to original sources
PubMed1999

Dextromethorphan attenuates ethanol withdrawal syndrome in rats.

The effects of dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors, have been investigated on ethanol withdrawal signs in rats. Ethanol (7.2% v/v) was given to rats in a liquid diet for 16 days. DM (10, 20, and 40 mg/kg) and saline were injected intraperitoneally at the third hour of ethanol withdrawal. DM (40 mg/kg) and ethanol dependent saline were also administered to ethanol naive rats. DM (40 mg/kg) did not produce any significant change in locomotor activity in ethanol naive rats. The effects of DM on locomotor activity and total ethanol withdrawal score were evaluated at the fourth and sixth hours of ethanol withdrawal. DM inhibited locomotor hyperactivity at these periods. DM also reduced total ethanol withdrawal score from the fourth hour to the sixth hour, and it significantly decreased audiogenic seizures. Seizure susceptibility after chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes and NMDA receptors. Our results suggest that inhibition of NMDA receptors by DM alleviates signs of ethanol withdrawal.

Acoustic Stimulation↗
PubMed1998

The effect of isradipine on maximal electroshock seizures in mice.

1. The aim of this study was to investigate the possible anticonvulsant effect of a dihydropyridine calcium antagonist, isradipine, which easily crosses the blood-brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures in mice. 2. Isradipine at i.p. doses of 2.5 mg/kg and 5.0 mg/kg was found to cause a statistically significant increase in the convulsion threshold of maximal electroshock seizures in a dose-dependent manner (P = 0.047 and P = 0.022, respectively). 3. It was concluded that the mode of action of the anticonvulsant effect of isradipine is related to blockade of the intraneuronal calcium currents, which play an important role in epileptic activity.

Animals↗
PubMed1997

The effect of 7-nitro indazole on pentobarbital-induced sleep in mice.

The sleep-wakefulness continuity is sensitive to a wide range of agents with pharmacological activity. There is some strong evidence about the role of nitric oxide (NO) as an intercellular messenger in the central physiological mechanisms. The effects of 7-nitro indazole (7-NI 15, 30, 60 mg kg-1; intraperitoneal, i.p.), a selective inhibitor of neuronal nitric oxide synthase (NOS) and L-arginine (500, 1000 mg kg-1, i.p.), a NO precursor, on pentobarbital (35 mg kg-1, i.p.) sleep were examined in mice. Loss of the righting reflex was used to determine the start of sleep. Sleep latency and sleeping time were evaluated in each experiment. 7-Nitro indazole (7-NI 30 mg kg-1; i.p.), had no apparent effect on sleep latency but significantly increased sleeping time (P < 0.02) on pentobarbital sleep in mice. L-Arginine had no effect on both parameters. These findings suggest that NO might be an important modulator of sleep regulation and implicate that inhibition of release and/or synthesis of NO might lead to changes in the maintenance of sleep.

Animals↗
PubMed1997

Antinociception induced by verapamil and chloramphenicol in mice.

The analgesic effects of verapamil, a calcium channel blocker, and chloramphenicol, a phenicolated antibiotic, were compared using the test of acetic-acid-induced writhing and the hot-plate test in mice. The results suggest that both drugs have antinociceptive properties comparable to salicylate analgesia. No significant difference was found between verapamil- and chloramphenicol-induced analgesia (p < 0.05).

Analgesia↗
PubMed1997

Protective role of immobilization on ouabain-induced arrhythmias.

The effects of the opioid-type stressor, immobilization, on severity of ouabain-induced cardiac arrhythmias and the possible involvement of serum catecholamines were investigated in rats. Immobilization significantly reduced the number of ventricular premature beats and the incidence of ventricular tachycardia episodes. The arterial serum catecholamine levels (A, NA and DA), measured immediately after the stressor application, were increased significantly and were in negative correlation with the arrhythmia parameters. Both changes were reversed by naloxone (5 mg/kg) treatment after application of immobilization. The effects observed in this study may be attributed to the actions of endogenous opioid peptides released during stress.

Animals↗
PubMed1996

Effects of opioid-type stressors on serum digoxin-like immunoreactivity in rats.

The effects of opioid-type stressors (immobilization, electric footshock and forced swimming) on serum digoxin-like immunoreactivity (SDLI) were investigated in rats. All of the stressors significantly elevated the SDLI. Naloxone treatment after application of stressors prevented the elevation of SDLI, whereas naloxone treatment alone did not cause any significant changes. The observed increase in SDLI in this study may be attributed to the actions of endogenous opioid peptides released during stress.

Animals↗