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Biomedical subjects

G Zagurov

Publications and source records attributed to G Zagurov.

At least 19 recordsLinked to original sources
PubMed1990

[Appendicitis in old age].

Proceeding from the results of histomorphologic examination of the appendix in senile age, an attempt is made to explain why the incidence of appendicitis in this age decreases. It was found that in senile age there occur involutive changes which lead to a decline in appendix reactivity and absence of potential possibility for appendicitis to occur. However seldom, the process of senile involution of the appendix may be retarded. In this case the lymph follicles in the appendix contain a germinative center, indicating preserved reactivity and potential possibility for inflammatory process to develop. Senile involution is an overall biological phenomenon, which refers not only to the appendix, but to all other lymph tissue in the body.

Aged↗
PubMed1989

[Unresolved and debatable questions on the problem of appendicitis].

On the basis of histomorphologic examination of: 9907 biopsy specimens from appendix, obtained after its surgical removal because of appendicitis, 228 cases of senile involution of the appendix and appendix specimens from 125 children 30 days to 8 years of age who had been immunized with BCG vaccine intracutaneously and have died of miscellaneous diseases, the author debates on some poorly specified and moot points in the appendicitis problem. Appendicitis is sometimes considered a phase and in other cases a form of the disease. It is assumed that chronic appendicitis, as well as primary chronic appendicitis not preceded by acute inflammatory changes in the appendix, do exist. Sufficient morphologic criteria to distinguish chronic appendicitis from senile involution of the appendix are believed to exist.

Acute Disease↗
PubMed1989

[Wound healing in the donor areas in burn patients].

A connective tissue regenerate, presented by granulation tissue, appears over the smooth and even surface of operative wounds produced by the dermatome scalpel in the donor areas in the process of healing. Argentophilic membrane appears over the free granulation surface. Source of wound epithelium regeneration at the donor areas is largely the epithelium of the skin appendages. At the end of the third week, with adequate healing, process, the wound in the donor areas epithelializes. The process of healing of this wound may be impeded, when infection with exudate appears on the granulation tissue surface. Then epithelialization of the wound does not occur.

Adolescent↗
PubMed1987

[Functional disorders and structural changes in the liver in Amanita phalloides poisoning].

The liver functional disorders and structural changes were studied in 17 patients (children 6, adults 11, 4 to 70 years of age) with phalloidine intoxication. The clinical course of this severe and lethal exogenic intoxication, its characteristic clinical and laboratory features are discussed in relation to the morphological changes of the liver. The structural changes are similar in all patients independently of their age and the time of death. They are presented by fatty degeneration, acute toxic liver dystrophy and centrilobular necroses. These changes are produced by the specific action of the phalloidine toxins on the liver.

Adolescent↗
PubMed1986

[Comparative morphological evaluation of the changes in the early and late stages of endemic nephropathy].

A comparative evaluation of the morphological changes from the early and late stages of endemic nephropathy is made on the base of biopsy and necropsy material. Thickened basal membranes partial obstruction and microaneurysms of the capillary of glomeruli are established during the early and late stages as well as thickening of mesangium but contrary to the early stages, sclerosis in interstitium and glomeruli develops in the late stages. Various dystrophic and necrobiotic changes in epithelium of the tubules are established during all stages of endemic nephropathy as well as intensified functional activity in epithelium of some tubules. Whereas edema in interstitium is established in the early stages of the disease, sclerosis in interstitium is established in the late stages, involving secondarily the glomeruli and tubules, as a result of dystrophic and necrobiotic changes in the tubules, and their collapse, in their late stages, is due to the progressively advancing sclerosis of interstitium, involving the glomeruli and inducing atrophic alterations in the tubuli.

Adolescent↗
PubMed1983

[Current problems in the pathology of burns].

+The results obtained from the study on thermal trauma were summarised on the base of histological, electron microscopic, immunologic and toxicological investigation methods. Shock during burning induces disturbances in the microcirculation. The great clinical significance of the alterations in lungs are stressed upon, manifested in a disorder of blood-gas barrier, permeability of the membranes of capillaries and cells, leading to acute pulmonary insufficiency. One of the probable mechanisms of anemia advancing after burns is described, that is due to the toxic effect of serum. Complement-fixation antibodies are found in the patients with burns, suggesting the involvement of autoimmune mechanisms in the course of the disease. The disturbed microcirculation has an unfavourable effect on the regeneration of wounds, leading to destruction of epithelial regeneration, disturbing the processes of revascularization of skin transplant, having an effect on the immune reactions of organism. Sepsis is discussed, with particular attention paid to that induced by Pseudomonas aeruginosa. In would cachexia some changes in the wounds are pointed to as well as sclerotic and atrophic processes in some internal organs, being usually irreversible. The reversibility if sclerosis in hypertrophic cicatrix and keloid is discussed, stressing on the cellular and extracellular mechanisms, involved in that process.

Adult↗
PubMed1975

[Morphological characteristics of the destructive and reparative changes in tuberculosis in those dying of nontubercular diseases].

The evolution of destructive and restorative alterations was morphologically followed up in 82 tuberculotics that died of non-tiberculous diseases. In the majority of the deceased, the restorative alterations were observed with manifested mesenchymal and immunologic reactions with morphological peculiarities as in the treated with anti tuberculous remedies. The destructive alteration are clearly manifested and the restorative manifestations are depressed in tuberculotics with non-treated diabetes and osteomyelitis treated with cortison. In a negligible part of the patients died of non-tuberculous diseases, a reactivation of the foci developed around the fibrocaseous lung foci, tracheobronchial lymph nodes, kidneys and suprarenals, manifested with filamented neutrophyils in the calcified and caseous matter, fresh necrosis, tubercula, specific granular tissue, friable capsule with appearance of lymphoid cells and specific granular tissue.

Acute Disease↗
PubMed1975

[Histomorphology of the microcirculation of the skin in physiological and pathological processes].

On the base of skin histomorphological investigations of 985 deceased with different diseases age morphological pecularities in microcirculation were concluded to exist as well as changes depending on the duration and character of the pathological process. The involvement of a great number of vessels is an index for increased functional microcirculation requirements. The microcirculation character cannot be defined only by the morphological pecularities of single capillaries, by quantitative and qualitative changes in them. The capillary changes relfect only part of the microcirculation changes. All microcirculation peculiarities cannot be deciphered by the histomorphological method of the investigation but that method supplies valuable data that cannot be obtained by the other investigation methods. Three stages of changes in microcirculation are specified, being morphologically characterized. The changes in the microcirculation of the nail mantle skin are non-specific, functional, organic, reversible, non-reversible and usually compensated.

Adolescent↗